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2005


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Large Scale Genomic Sequence SVM Classifiers

Sonnenburg, S., Rätsch, G., Schölkopf, B.

In Proceedings of the 22nd International Conference on Machine Learning, pages: 849-856, (Editors: L De Raedt and S Wrobel), ACM, New York, NY, USA, ICML, 2005 (inproceedings)

Abstract
In genomic sequence analysis tasks like splice site recognition or promoter identification, large amounts of training sequences are available, and indeed needed to achieve sufficiently high classification performances. In this work we study two recently proposed and successfully used kernels, namely the Spectrum kernel and the Weighted Degree kernel (WD). In particular, we suggest several extensions using Suffix Trees and modi cations of an SMO-like SVM training algorithm in order to accelerate the training of the SVMs and their evaluation on test sequences. Our simulations show that for the spectrum kernel and WD kernel, large scale SVM training can be accelerated by factors of 20 and 4 times, respectively, while using much less memory (e.g. no kernel caching). The evaluation on new sequences is often several thousand times faster using the new techniques (depending on the number of Support Vectors). Our method allows us to train on sets as large as one million sequences.

ei

PDF [BibTex]

2005


PDF [BibTex]


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Joint Kernel Maps

Weston, J., Schölkopf, B., Bousquet, O.

In Proceedings of the 8th InternationalWork-Conference on Artificial Neural Networks, LNCS 3512, pages: 176-191, (Editors: J Cabestany and A Prieto and F Sandoval), Springer, Berlin Heidelberg, Germany, IWANN, 2005 (inproceedings)

Abstract
We develop a methodology for solving high dimensional dependency estimation problems between pairs of data types, which is viable in the case where the output of interest has very high dimension, e.g., thousands of dimensions. This is achieved by mapping the objects into continuous or discrete spaces, using joint kernels. Known correlations between input and output can be defined by such kernels, some of which can maintain linearity in the outputs to provide simple (closed form) pre-images. We provide examples of such kernels and empirical results.

ei

PostScript DOI [BibTex]

PostScript DOI [BibTex]


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Analysis of Some Methods for Reduced Rank Gaussian Process Regression

Quinonero Candela, J., Rasmussen, C.

In Switching and Learning in Feedback Systems, pages: 98-127, (Editors: Murray Smith, R. , R. Shorten), Springer, Berlin, Germany, European Summer School on Multi-Agent Control, 2005 (inproceedings)

Abstract
While there is strong motivation for using Gaussian Processes (GPs) due to their excellent performance in regression and classification problems, their computational complexity makes them impractical when the size of the training set exceeds a few thousand cases. This has motivated the recent proliferation of a number of cost-effective approximations to GPs, both for classification and for regression. In this paper we analyze one popular approximation to GPs for regression: the reduced rank approximation. While generally GPs are equivalent to infinite linear models, we show that Reduced Rank Gaussian Processes (RRGPs) are equivalent to finite sparse linear models. We also introduce the concept of degenerate GPs and show that they correspond to inappropriate priors. We show how to modify the RRGP to prevent it from being degenerate at test time. Training RRGPs consists both in learning the covariance function hyperparameters and the support set. We propose a method for learning hyperparameters for a given support set. We also review the Sparse Greedy GP (SGGP) approximation (Smola and Bartlett, 2001), which is a way of learning the support set for given hyperparameters based on approximating the posterior. We propose an alternative method to the SGGP that has better generalization capabilities. Finally we make experiments to compare the different ways of training a RRGP. We provide some Matlab code for learning RRGPs.

ei

PDF PDF DOI [BibTex]

PDF PDF DOI [BibTex]


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Graph Kernels for Chemical Informatics

Ralaivola, L., Swamidass, J., Saigo, H., Baldi, P.

Neural Networks, 18(8):1093-1110, 2005 (article)

Abstract
Increased availability of large repositories of chemical compounds is creating new challenges and opportunities for the application of machine learning methods to problems in computational chemistry and chemical informatics. Because chemical compounds are often represented by the graph of their covalent bonds, machine learning methods in this domain must be capable of processing graphical structures with variable size. Here we first briefly review the literature on graph kernels and then introduce three new kernels (Tanimoto, MinMax, Hybrid) based on the idea of molecular fingerprints and counting labeled paths of depth up to d using depthfirst search from each possible vertex. The kernels are applied to three classification problems to predict mutagenicity, toxicity, and anti-cancer activity on three publicly available data sets. The kernels achieve performances at least comparable, and most often superior, to those previously reported in the literature reaching accuracies of 91.5% on the Mutag dataset, 65-67% on the PTC (Predictive Toxicology Challenge) dataset, and 72% on the NCI (National Cancer Institute) dataset. Properties and tradeoffs of these kernels, as well as other proposed kernels that leverage 1D or 3D representations of molecules, are briefly discussed.

ei

PDF DOI [BibTex]

PDF DOI [BibTex]


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Extended Gaussianization Method for Blind Separation of Post-Nonlinear Mixtures

Zhang, K., Chan, L.

Neural Computation, 17(2):425-452, 2005 (article)

Abstract
The linear mixture model has been investigated in most articles tackling the problem of blind source separation. Recently, several articles have addressed a more complex model: blind source separation (BSS) of post-nonlinear (PNL) mixtures. These mixtures are assumed to be generated by applying an unknown invertible nonlinear distortion to linear instantaneous mixtures of some independent sources. The gaussianization technique for BSS of PNL mixtures emerged based on the assumption that the distribution of the linear mixture of independent sources is gaussian. In this letter, we review the gaussianization method and then extend it to apply to PNL mixture in which the linear mixture is close to gaussian. Our proposed method approximates the linear mixture using the Cornish-Fisher expansion. We choose the mutual information as the independence measurement to develop a learning algorithm to separate PNL mixtures. This method provides better applicability and accuracy. We then discuss the sufficient condition for the method to be valid. The characteristics of the nonlinearity do not affect the performance of this method. With only a few parameters to tune, our algorithm has a comparatively low computation. Finally, we present experiments to illustrate the efficiency of our method.

ei

Web DOI [BibTex]


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Theory of Classification: A Survey of Some Recent Advances

Boucheron, S., Bousquet, O., Lugosi, G.

ESAIM: Probability and Statistics, 9, pages: 323 , 2005 (article)

Abstract
The last few years have witnessed important new developments in the theory and practice of pattern classification. We intend to survey some of the main new ideas that have lead to these important recent developments.

ei

PDF DOI [BibTex]

PDF DOI [BibTex]


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From Graphs to Manifolds - Weak and Strong Pointwise Consistency of Graph Laplacians

Hein, M., Audibert, J., von Luxburg, U.

In Proceedings of the 18th Conference on Learning Theory (COLT), pages: 470-485, Conference on Learning Theory, 2005, Student Paper Award (inproceedings)

Abstract
In the machine learning community it is generally believed that graph Laplacians corresponding to a finite sample of data points converge to a continuous Laplace operator if the sample size increases. Even though this assertion serves as a justification for many Laplacian-based algorithms, so far only some aspects of this claim have been rigorously proved. In this paper we close this gap by establishing the strong pointwise consistency of a family of graph Laplacians with data-dependent weights to some weighted Laplace operator. Our investigation also includes the important case where the data lies on a submanifold of $R^d$.

ei

PDF [BibTex]

PDF [BibTex]


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Propagating Distributions on a Hypergraph by Dual Information Regularization

Tsuda, K.

In Proceedings of the 22nd International Conference on Machine Learning, pages: 921 , (Editors: De Raedt, L. , S. Wrobel), ICML Bonn, 2005 (inproceedings)

Abstract
In the information regularization framework by Corduneanu and Jaakkola (2005), the distributions of labels are propagated on a hypergraph for semi-supervised learning. The learning is efficiently done by a Blahut-Arimoto-like two step algorithm, but, unfortunately, one of the steps cannot be solved in a closed form. In this paper, we propose a dual version of information regularization, which is considered as more natural in terms of information geometry. Our learning algorithm has two steps, each of which can be solved in a closed form. Also it can be naturally applied to exponential family distributions such as Gaussians. In experiments, our algorithm is applied to protein classification based on a metabolic network and known functional categories.

ei

[BibTex]

[BibTex]


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Moment Inequalities for Functions of Independent Random Variables

Boucheron, S., Bousquet, O., Lugosi, G., Massart, P.

To appear in Annals of Probability, 33, pages: 514-560, 2005 (article)

Abstract
A general method for obtaining moment inequalities for functions of independent random variables is presented. It is a generalization of the entropy method which has been used to derive concentration inequalities for such functions cite{BoLuMa01}, and is based on a generalized tensorization inequality due to Lata{l}a and Oleszkiewicz cite{LaOl00}. The new inequalities prove to be a versatile tool in a wide range of applications. We illustrate the power of the method by showing how it can be used to effortlessly re-derive classical inequalities including Rosenthal and Kahane-Khinchine-type inequalities for sums of independent random variables, moment inequalities for suprema of empirical processes, and moment inequalities for Rademacher chaos and $U$-statistics. Some of these corollaries are apparently new. In particular, we generalize Talagrands exponential inequality for Rademacher chaos of order two to any order. We also discuss applications for other complex functions of independent random variables, such as suprema of boolean polynomials which include, as special cases, subgraph counting problems in random graphs.

ei

PDF [BibTex]

PDF [BibTex]


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A Brain Computer Interface with Online Feedback based on Magnetoencephalography

Lal, T., Schröder, M., Hill, J., Preissl, H., Hinterberger, T., Mellinger, J., Bogdan, M., Rosenstiel, W., Hofmann, T., Birbaumer, N., Schölkopf, B.

In Proceedings of the 22nd International Conference on Machine Learning, pages: 465-472, (Editors: L De Raedt and S Wrobel), ACM, New York, NY, USA, ICML, 2005 (inproceedings)

Abstract
The aim of this paper is to show that machine learning techniques can be used to derive a classifying function for human brain signal data measured by magnetoencephalography (MEG), for the use in a brain computer interface (BCI). This is especially helpful for evaluating quickly whether a BCI approach based on electroencephalography, on which training may be slower due to lower signalto- noise ratio, is likely to succeed. We apply recursive channel elimination and regularized SVMs to the experimental data of ten healthy subjects performing a motor imagery task. Four subjects were able to use a trained classifier together with a decision tree interface to write a short name. Further analysis gives evidence that the proposed imagination task is suboptimal for the possible extension to a multiclass interface. To the best of our knowledge this paper is the first working online BCI based on MEG recordings and is therefore a “proof of concept”.

ei

PDF PDF [BibTex]

PDF PDF [BibTex]


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Healing the Relevance Vector Machine through Augmentation

Rasmussen, CE., Candela, JQ.

In Proceedings of the 22nd International Conference on Machine Learning, pages: 689 , (Editors: De Raedt, L. , S. Wrobel), ICML, 2005 (inproceedings)

Abstract
The Relevance Vector Machine (RVM) is a sparse approximate Bayesian kernel method. It provides full predictive distributions for test cases. However, the predictive uncertainties have the unintuitive property, that emph{they get smaller the further you move away from the training cases}. We give a thorough analysis. Inspired by the analogy to non-degenerate Gaussian Processes, we suggest augmentation to solve the problem. The purpose of the resulting model, RVM*, is primarily to corroborate the theoretical and experimental analysis. Although RVM* could be used in practical applications, it is no longer a truly sparse model. Experiments show that sparsity comes at the expense of worse predictive distributions.

ei

PDF PostScript [BibTex]

PDF PostScript [BibTex]


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A novel representation of protein sequences for prediction of subcellular location using support vector machines

Matsuda, S., Vert, J., Saigo, H., Ueda, N., Toh, H., Akutsu, T.

Protein Science, 14, pages: 2804-2813, 2005 (article)

Abstract
As the number of complete genomes rapidly increases, accurate methods to automatically predict the subcellular location of proteins are increasingly useful to help their functional annotation. In order to improve the predictive accuracy of the many prediction methods developed to date, a novel representation of protein sequences is proposed. This representation involves local compositions of amino acids and twin amino acids, and local frequencies of distance between successive (basic, hydrophobic, and other) amino acids. For calculating the local features, each sequence is split into three parts: N-terminal, middle, and C-terminal. The N-terminal part is further divided into four regions to consider ambiguity in the length and position of signal sequences. We tested this representation with support vector machines on two data sets extracted from the SWISS-PROT database. Through fivefold cross-validation tests, overall accuracies of more than 87% and 91% were obtained for eukaryotic and prokaryotic proteins, respectively. It is concluded that considering the respective features in the N-terminal, middle, and C-terminal parts is helpful to predict the subcellular location. Keywords: subcellular location; signal sequence; amino acid composition; distance frequency; support vector machine; predictive accuracy

ei

Web DOI [BibTex]

Web DOI [BibTex]


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Long Term Prediction of Product Quality in a Glass Manufacturing Process Using a Kernel Based Approach

Jung, T., Herrera, L., Schölkopf, B.

In Proceedings of the 8th International Work-Conferenceon Artificial Neural Networks (Computational Intelligence and Bioinspired Systems), Lecture Notes in Computer Science, Vol. 3512, LNCS 3512, pages: 960-967, (Editors: J Cabestany and A Prieto and F Sandoval), Springer, Berlin Heidelberg, Germany, IWANN, 2005 (inproceedings)

Abstract
In this paper we report the results obtained using a kernel-based approach to predict the temporal development of four response signals in the process control of a glass melting tank with 16 input parameters. The data set is a revised version1 from the modelling challenge in EUNITE-2003. The central difficulties are: large time-delays between changes in the inputs and the outputs, large number of data, and a general lack of knowledge about the relevant variables that intervene in the process. The methodology proposed here comprises Support Vector Machines (SVM) and Regularization Networks (RN). We use the idea of sparse approximation both as a means of regularization and as a means of reducing the computational complexity. Furthermore, we will use an incremental approach to add new training examples to the kernel-based method and efficiently update the current solution. This allows us to use a sophisticated learning scheme, where we iterate between prediction and training, with good computational efficiency and satisfactory results.

ei

DOI [BibTex]

DOI [BibTex]


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Object correspondence as a machine learning problem

Schölkopf, B., Steinke, F., Blanz, V.

In Proceedings of the 22nd International Conference on Machine Learning, pages: 777-784, (Editors: L De Raedt and S Wrobel), ACM, New York, NY, USA, ICML, 2005 (inproceedings)

Abstract
We propose machine learning methods for the estimation of deformation fields that transform two given objects into each other, thereby establishing a dense point to point correspondence. The fields are computed using a modified support vector machine containing a penalty enforcing that points of one object will be mapped to ``similar‘‘ points on the other one. Our system, which contains little engineering or domain knowledge, delivers state of the art performance. We present application results including close to photorealistic morphs of 3D head models.

ei

PDF [BibTex]

PDF [BibTex]


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A tutorial on v-support vector machines

Chen, P., Lin, C., Schölkopf, B.

Applied Stochastic Models in Business and Industry, 21(2):111-136, 2005 (article)

Abstract
We briefly describe the main ideas of statistical learning theory, support vector machines (SVMs), and kernel feature spaces. We place particular emphasis on a description of the so-called -SVM, including details of the algorithm and its implementation, theoretical results, and practical applications. Copyright © 2005 John Wiley & Sons, Ltd.

ei

PDF [BibTex]

PDF [BibTex]


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Robust EEG Channel Selection Across Subjects for Brain Computer Interfaces

Schröder, M., Lal, T., Hinterberger, T., Bogdan, M., Hill, J., Birbaumer, N., Rosenstiel, W., Schölkopf, B.

EURASIP Journal on Applied Signal Processing, 2005(19, Special Issue: Trends in Brain Computer Interfaces):3103-3112, (Editors: Vesin, J. M., T. Ebrahimi), 2005 (article)

Abstract
Most EEG-based Brain Computer Interface (BCI) paradigms come along with specific electrode positions, e.g.~for a visual based BCI electrode positions close to the primary visual cortex are used. For new BCI paradigms it is usually not known where task relevant activity can be measured from the scalp. For individual subjects Lal et.~al showed that recording positions can be found without the use of prior knowledge about the paradigm used. However it remains unclear to what extend their method of Recursive Channel Elimination (RCE) can be generalized across subjects. In this paper we transfer channel rankings from a group of subjects to a new subject. For motor imagery tasks the results are promising, although cross-subject channel selection does not quite achieve the performance of channel selection on data of single subjects. Although the RCE method was not provided with prior knowledge about the mental task, channels that are well known to be important (from a physiological point of view) were consistently selected whereas task-irrelevant channels were reliably disregarded.

ei

Web DOI [BibTex]

Web DOI [BibTex]


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Implicit Surface Modelling as an Eigenvalue Problem

Walder, C., Chapelle, O., Schölkopf, B.

In Proceedings of the 22nd International Conference on Machine Learning, pages: 937-944, (Editors: L De Raedt and S Wrobel), ACM, New York, NY, USA, ICML, 2005 (inproceedings)

Abstract
We discuss the problem of fitting an implicit shape model to a set of points sampled from a co-dimension one manifold of arbitrary topology. The method solves a non-convex optimisation problem in the embedding function that defines the implicit by way of its zero level set. By assuming that the solution is a mixture of radial basis functions of varying widths we attain the globally optimal solution by way of an equivalent eigenvalue problem, without using or constructing as an intermediate step the normal vectors of the manifold at each data point. We demonstrate the system on two and three dimensional data, with examples of missing data interpolation and set operations on the resultant shapes.

ei

PDF [BibTex]

PDF [BibTex]


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Natural Actor-Critic

Peters, J., Vijayakumar, S., Schaal, S.

In Proceedings of the 16th European Conference on Machine Learning, 3720, pages: 280-291, (Editors: Gama, J.;Camacho, R.;Brazdil, P.;Jorge, A.;Torgo, L.), Springer, ECML, 2005, clmc (inproceedings)

Abstract
This paper investigates a novel model-free reinforcement learning architecture, the Natural Actor-Critic. The actor updates are based on stochastic policy gradients employing AmariÕs natural gradient approach, while the critic obtains both the natural policy gradient and additional parameters of a value function simultaneously by linear regres- sion. We show that actor improvements with natural policy gradients are particularly appealing as these are independent of coordinate frame of the chosen policy representation, and can be estimated more efficiently than regular policy gradients. The critic makes use of a special basis function parameterization motivated by the policy-gradient compatible function approximation. We show that several well-known reinforcement learning methods such as the original Actor-Critic and BradtkeÕs Linear Quadratic Q-Learning are in fact Natural Actor-Critic algorithms. Em- pirical evaluations illustrate the effectiveness of our techniques in com- parison to previous methods, and also demonstrate their applicability for learning control on an anthropomorphic robot arm.

am ei

link (url) DOI [BibTex]

link (url) DOI [BibTex]


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Comparative experiments on task space control with redundancy resolution

Nakanishi, J., Cory, R., Mistry, M., Peters, J., Schaal, S.

In Proceedings of the 2005 IEEE/RSJ International Conference on Intelligent Robots and Systems, pages: 3901-3908, Edmonton, Alberta, Canada, Aug. 2-6, IROS, 2005, clmc (inproceedings)

Abstract
Understanding the principles of motor coordination with redundant degrees of freedom still remains a challenging problem, particularly for new research in highly redundant robots like humanoids. Even after more than a decade of research, task space control with redundacy resolution still remains an incompletely understood theoretical topic, and also lacks a larger body of thorough experimental investigation on complex robotic systems. This paper presents our first steps towards the development of a working redundancy resolution algorithm which is robust against modeling errors and unforeseen disturbances arising from contact forces. To gain a better understanding of the pros and cons of different approaches to redundancy resolution, we focus on a comparative empirical evaluation. First, we review several redundancy resolution schemes at the velocity, acceleration and torque levels presented in the literature in a common notational framework and also introduce some new variants of these previous approaches. Second, we present experimental comparisons of these approaches on a seven-degree-of-freedom anthropomorphic robot arm. Surprisingly, one of our simplest algorithms empirically demonstrates the best performance, despite, from a theoretical point, the algorithm does not share the same beauty as some of the other methods. Finally, we discuss practical properties of these control algorithms, particularly in light of inevitable modeling errors of the robot dynamics.

am ei

link (url) DOI [BibTex]

link (url) DOI [BibTex]


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A model of smooth pursuit based on learning of the target dynamics using only retinal signals

Shibata, T., Tabata, H., Schaal, S., Kawato, M.

Neural Networks, 18, pages: 213-225, 2005, clmc (article)

Abstract
While the predictive nature of the primate smooth pursuit system has been evident through several behavioural and neurophysiological experiments, few models have attempted to explain these results comprehensively. The model we propose in this paper in line with previous models employing optimal control theory; however, we hypothesize two new issues: (1) the medical superior temporal (MST) area in the cerebral cortex implements a recurrent neural network (RNN) in order to predict the current or future target velocity, and (2) a forward model of the target motion is acquired by on-line learning. We use stimulation studies to demonstrate how our new model supports these hypotheses.

am

link (url) [BibTex]

link (url) [BibTex]


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Predicting EMG Data from M1 Neurons with Variational Bayesian Least Squares

Ting, J., D’Souza, A., Yamamoto, K., Yoshioka, T., Hoffman, D., Kakei, S., Sergio, L., Kalaska, J., Kawato, M., Strick, P., Schaal, S.

In Advances in Neural Information Processing Systems 18 (NIPS 2005), (Editors: Weiss, Y.;Schölkopf, B.;Platt, J.), Cambridge, MA: MIT Press, Vancouver, BC, Dec. 6-11, 2005, clmc (inproceedings)

Abstract
An increasing number of projects in neuroscience requires the statistical analysis of high dimensional data sets, as, for instance, in predicting behavior from neural firing, or in operating artificial devices from brain recordings in brain-machine interfaces. Linear analysis techniques remain prevalent in such cases, but classi-cal linear regression approaches are often numercially too fragile in high dimen-sions. In this paper, we address the question of whether EMG data collected from arm movements of monkeys can be faithfully reconstructed with linear ap-proaches from neural activity in primary motor cortex (M1). To achieve robust data analysis, we develop a full Bayesian approach to linear regression that automatically detects and excludes irrelevant features in the data, and regular-izes against overfitting. In comparison with ordinary least squares, stepwise re-gression, partial least squares, and a brute force combinatorial search for the most predictive input features in the data, we demonstrate that the new Bayesian method offers a superior mixture of characteristics in terms of regularization against overfitting, computational efficiency, and ease of use, demonstrating its potential as a drop-in replacement for other linear regression techniques. As neuroscientific results, our analyses demonstrate that EMG data can be well pre-dicted from M1 neurons, further opening the path for possible real-time inter-faces between brains and machines.

am

link (url) [BibTex]

link (url) [BibTex]


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Rapbid synchronization and accurate phase-locking of rhythmic motor primitives

Pongas, D., Billard, A., Schaal, S.

In IEEE International Conference on Intelligent Robots and Systems (IROS 2005), pages: 2911-2916, Edmonton, Alberta, Canada, Aug. 2-6, 2005, clmc (inproceedings)

Abstract
Rhythmic movement is ubiquitous in human and animal behavior, e.g., as in locomotion, dancing, swimming, chewing, scratching, music playing, etc. A particular feature of rhythmic movement in biology is the rapid synchronization and phase locking with other rhythmic events in the environment, for instance music or visual stimuli as in ball juggling. In traditional oscillator theories to rhythmic movement generation, synchronization with another signal is relatively slow, and it is not easy to achieve accurate phase locking with a particular feature of the driving stimulus. Using a recently developed framework of dynamic motor primitives, we demonstrate a novel algorithm for very rapid synchronizaton of a rhythmic movement pattern, which can phase lock any feature of the movement to any particulur event in the driving stimulus. As an example application, we demonstrate how an anthropomorphic robot can use imitation learning to acquire a complex rumming pattern and keep it synchronized with an external rhythm generator that changes its frequency over time.

am

link (url) [BibTex]

link (url) [BibTex]


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Parametric and Non-Parametric approaches for nonlinear tracking of moving objects

Hidaka, Y, Theodorou, E.

Technical Report-2005-1, 2005, clmc (article)

am

PDF [BibTex]

PDF [BibTex]


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A new methodology for robot control design

Peters, J., Mistry, M., Udwadia, F. E., Schaal, S.

In The 5th ASME International Conference on Multibody Systems, Nonlinear Dynamics, and Control (MSNDC 2005), Long Beach, CA, Sept. 24-28, 2005, clmc (inproceedings)

Abstract
Gauss principle of least constraint and its generalizations have provided a useful insights for the development of tracking controllers for mechanical systems (Udwadia,2003). Using this concept, we present a novel methodology for the design of a specific class of robot controllers. With our new framework, we demonstrate that well-known and also several novel nonlinear robot control laws can be derived from this generic framework, and show experimental verifications on a Sarcos Master Arm robot for some of these controllers. We believe that the suggested approach unifies and simplifies the design of optimal nonlinear control laws for robots obeying rigid body dynamics equations, both with or without external constraints, holonomic or nonholonomic constraints, with over-actuation or underactuation, as well as open-chain and closed-chain kinematics.

am

link (url) [BibTex]

link (url) [BibTex]


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Arm movement experiments with joint space force fields using an exoskeleton robot

Mistry, M., Mohajerian, P., Schaal, S.

In IEEE Ninth International Conference on Rehabilitation Robotics, pages: 408-413, Chicago, Illinois, June 28-July 1, 2005, clmc (inproceedings)

Abstract
A new experimental platform permits us to study a novel variety of issues of human motor control, particularly full 3-D movements involving the major seven degrees-of-freedom (DOF) of the human arm. We incorporate a seven DOF robot exoskeleton, and can minimize weight and inertia through gravity, Coriolis, and inertia compensation, such that subjects' arm movements are largely unaffected by the manipulandum. Torque perturbations can be individually applied to any or all seven joints of the human arm, thus creating novel dynamic environments, or force fields, for subjects to respond and adapt to. Our first study investigates a joint space force field where the shoulder velocity drives a disturbing force in the elbow joint. Results demonstrate that subjects learn to compensate for the force field within about 100 trials, and from the strong presence of aftereffects when removing the field in some randomized catch trials, that an inverse dynamics, or internal model, of the force field is formed by the nervous system. Interestingly, while post-learning hand trajectories return to baseline, joint space trajectories remained changed in response to the field, indicating that besides learning a model of the force field, the nervous system also chose to exploit the space to minimize the effects of the force field on the realization of the endpoint trajectory plan. Further applications for our apparatus include studies in motor system redundancy resolution and inverse kinematics, as well as rehabilitation.

am

link (url) [BibTex]

link (url) [BibTex]


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A unifying framework for the control of robotics systems

Peters, J., Mistry, M., Udwadia, F. E., Cory, R., Nakanishi, J., Schaal, S.

In IEEE International Conference on Intelligent Robots and Systems (IROS 2005), pages: 1824-1831, Edmonton, Alberta, Canada, Aug. 2-6, 2005, clmc (inproceedings)

Abstract
Recently, [1] suggested to derive tracking controllers for mechanical systems using a generalization of GaussÕ principle of least constraint. This method al-lows us to reformulate control problems as a special class of optimal control. We take this line of reasoning one step further and demonstrate that well-known and also several novel nonlinear robot control laws can be derived from this generic methodology. We show experimental verifications on a Sar-cos Master Arm robot for some of the the derived controllers.We believe that the suggested approach offers a promising unification and simplification of nonlinear control law design for robots obeying rigid body dynamics equa-tions, both with or without external constraints, with over-actuation or under-actuation, as well as open-chain and closed-chain kinematics.

am

link (url) [BibTex]

link (url) [BibTex]

2000


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Knowledge Discovery in Databases: An Information Retrieval Perspective

Ong, CS.

Malaysian Journal of Computer Science, 13(2):54-63, December 2000 (article)

Abstract
The current trend of increasing capabilities in data generation and collection has resulted in an urgent need for data mining applications, also called knowledge discovery in databases. This paper identifies and examines the issues involved in extracting useful grains of knowledge from large amounts of data. It describes a framework to categorise data mining systems. The author also gives an overview of the issues pertaining to data pre processing, as well as various information gathering methodologies and techniques. The paper covers some popular tools such as classification, clustering, and generalisation. A summary of statistical and machine learning techniques used currently is also provided.

ei

PDF [BibTex]

2000


PDF [BibTex]


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A real-time model of the human knee for application in virtual orthopaedic trainer

Peters, J., Riener, R.

In Proceedings of the 10th International Conference on BioMedical Engineering (ICBME 2000), 10, pages: 1-2, 10th International Conference on BioMedical Engineering (ICBME) , December 2000 (inproceedings)

Abstract
In this paper a real-time capable computational model of the human knee is presented. The model describes the passive elastic joint characteristics in six degrees-of-freedom (DOF). A black-box approach was chosen, where experimental data were approximated by piecewise polynomial functions. The knee model has been applied in a the Virtual Orthopaedic Trainer, which can support training of physical knee evaluation required for diagnosis and surgical planning.

ei

PDF Web [BibTex]

PDF Web [BibTex]


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Reciprocal excitation between biological and robotic research

Schaal, S., Sternad, D., Dean, W., Kotoska, S., Osu, R., Kawato, M.

In Sensor Fusion and Decentralized Control in Robotic Systems III, Proceedings of SPIE, 4196, pages: 30-40, Boston, MA, Nov.5-8, 2000, November 2000, clmc (inproceedings)

Abstract
While biological principles have inspired researchers in computational and engineering research for a long time, there is still rather limited knowledge flow back from computational to biological domains. This paper presents examples of our work where research on anthropomorphic robots lead us to new insights into explaining biological movement phenomena, starting from behavioral studies up to brain imaging studies. Our research over the past years has focused on principles of trajectory formation with nonlinear dynamical systems, on learning internal models for nonlinear control, and on advanced topics like imitation learning. The formal and empirical analyses of the kinematics and dynamics of movements systems and the tasks that they need to perform lead us to suggest principles of motor control that later on we found surprisingly related to human behavior and even brain activity.

am

link (url) [BibTex]

link (url) [BibTex]


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A Simple Iterative Approach to Parameter Optimization

Zien, A., Zimmer, R., Lengauer, T.

Journal of Computational Biology, 7(3,4):483-501, November 2000 (article)

Abstract
Various bioinformatics problems require optimizing several different properties simultaneously. For example, in the protein threading problem, a scoring function combines the values for different parameters of possible sequence-to-structure alignments into a single score to allow for unambiguous optimization. In this context, an essential question is how each property should be weighted. As the native structures are known for some sequences, a partial ordering on optimal alignments to other structures, e.g., derived from structural comparisons, may be used to adjust the weights. To resolve the arising interdependence of weights and computed solutions, we propose a heuristic approach: iterating the computation of solutions (here, threading alignments) given the weights and the estimation of optimal weights of the scoring function given these solutions via systematic calibration methods. For our application (i.e., threading), this iterative approach results in structurally meaningful weights that significantly improve performance on both the training and the test data sets. In addition, the optimized parameters show significant improvements on the recognition rate for a grossly enlarged comprehensive benchmark, a modified recognition protocol as well as modified alignment types (local instead of global and profiles instead of single sequences). These results show the general validity of the optimized weights for the given threading program and the associated scoring contributions.

ei

Web [BibTex]

Web [BibTex]


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Identification of Drug Target Proteins

Zien, A., Küffner, R., Mevissen, T., Zimmer, R., Lengauer, T.

ERCIM News, 43, pages: 16-17, October 2000 (article)

ei

Web [BibTex]

Web [BibTex]


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On Designing an Automated Malaysian Stemmer for the Malay Language

Tai, SY., Ong, CS., Abullah, NA.

In Fifth International Workshop on Information Retrieval with Asian Languages, pages: 207-208, ACM Press, New York, NY, USA, Fifth International Workshop on Information Retrieval with Asian Languages, October 2000 (inproceedings)

Abstract
Online and interactive information retrieval systems are likely to play an increasing role in the Malay Language community. To facilitate and automate the process of matching morphological term variants, a stemmer focusing on common affix removal algorithms is proposed as part of the design of an information retrieval system for the Malay Language. Stemming is a morphological process of normalizing word tokens down to their essential roots. The proposed stemmer strips prefixes and suffixes off the word. The experiment conducted with web sites selected from the World Wide Web has exhibited substantial improvements in the number of words indexed.

ei

PostScript Web DOI [BibTex]

PostScript Web DOI [BibTex]


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Ensemble of Specialized Networks based on Input Space Partition

Shin, H., Lee, H., Cho, S.

In Proc. of the Korean Operations Research and Management Science Conference, pages: 33-36, Korean Operations Research and Management Science Conference, October 2000 (inproceedings)

ei

[BibTex]

[BibTex]


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DES Approach Failure Recovery of Pump-valve System

Son, HI., Kim, KW., Lee, S.

In Korean Society of Precision Engineering (KSPE) Conference, pages: 647-650, Annual Meeting of the Korean Society of Precision Engineering (KSPE), October 2000 (inproceedings)

ei

PDF [BibTex]

PDF [BibTex]


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Ensemble Learning Algorithm of Specialized Networks

Shin, H., Lee, H., Cho, S.

In Proc. of the Korea Information Science Conference, pages: 308-310, Korea Information Science Conference, October 2000 (inproceedings)

ei

[BibTex]

[BibTex]


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DES Approach Failure Diagnosis of Pump-valve System

Son, HI., Kim, KW., Lee, S.

In Korean Society of Precision Engineering (KSPE) Conference, pages: 643-646, Annual Meeting of the Korean Society of Precision Engineering (KSPE), October 2000 (inproceedings)

Abstract
As many industrial systems become more complex, it becomes extremely difficult to diagnose the cause of failures. This paper presents a failure diagnosis approach based on discrete event system theory. In particular, the approach is a hybrid of event-based and state-based ones leading to a simpler failure diagnoser with supervisory control capability. The design procedure is presented along with a pump-valve system as an example.

ei

PDF [BibTex]

PDF [BibTex]


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Nonlinear dynamical systems as movement primitives

Schaal, S., Kotosaka, S., Sternad, D.

In Humanoids2000, First IEEE-RAS International Conference on Humanoid Robots, CD-Proceedings, Cambridge, MA, September 2000, clmc (inproceedings)

Abstract
This paper explores the idea to create complex human-like movements from movement primitives based on nonlinear attractor dynamics. Each degree-of-freedom of a limb is assumed to have two independent abilities to create movement, one through a discrete dynamic system, and one through a rhythmic system. The discrete system creates point-to-point movements based on internal or external target specifications. The rhythmic system can add an additional oscillatory movement relative to the current position of the discrete system. In the present study, we develop appropriate dynamic systems that can realize the above model, motivate the particular choice of the systems from a biological and engineering point of view, and present simulation results of the performance of such movement primitives. The model was implemented for a drumming task on a humanoid robot

am

link (url) [BibTex]

link (url) [BibTex]


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Real Time Learning in Humanoids: A challenge for scalability of Online Algorithms

Vijayakumar, S., Schaal, S.

In Humanoids2000, First IEEE-RAS International Conference on Humanoid Robots, CD-Proceedings, Cambridge, MA, September 2000, clmc (inproceedings)

Abstract
While recent research in neural networks and statistical learning has focused mostly on learning from finite data sets without stringent constraints on computational efficiency, there is an increasing number of learning problems that require real-time performance from an essentially infinite stream of incrementally arriving data. This paper demonstrates how even high-dimensional learning problems of this kind can successfully be dealt with by techniques from nonparametric regression and locally weighted learning. As an example, we describe the application of one of the most advanced of such algorithms, Locally Weighted Projection Regression (LWPR), to the on-line learning of the inverse dynamics model of an actual seven degree-of-freedom anthropomorphic robot arm. LWPR's linear computational complexity in the number of input dimensions, its inherent mechanisms of local dimensionality reduction, and its sound learning rule based on incremental stochastic leave-one-out cross validation allows -- to our knowledge for the first time -- implementing inverse dynamics learning for such a complex robot with real-time performance. In our sample task, the robot acquires the local inverse dynamics model needed to trace a figure-8 in only 60 seconds of training.

am

link (url) [BibTex]

link (url) [BibTex]


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Engineering Support Vector Machine Kernels That Recognize Translation Initiation Sites

Zien, A., Rätsch, G., Mika, S., Schölkopf, B., Lengauer, T., Müller, K.

Bioinformatics, 16(9):799-807, September 2000 (article)

Abstract
Motivation: In order to extract protein sequences from nucleotide sequences, it is an important step to recognize points at which regions start that code for proteins. These points are called translation initiation sites (TIS). Results: The task of finding TIS can be modeled as a classification problem. We demonstrate the applicability of support vector machines for this task, and show how to incorporate prior biological knowledge by engineering an appropriate kernel function. With the described techniques the recognition performance can be improved by 26% over leading existing approaches. We provide evidence that existing related methods (e.g. ESTScan) could profit from advanced TIS recognition.

ei

Web DOI [BibTex]

Web DOI [BibTex]


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Synchronized robot drumming by neural oscillator

Kotosaka, S., Schaal, S.

In The International Symposium on Adaptive Motion of Animals and Machines, Montreal, Canada, August 2000, clmc (inproceedings)

Abstract
Sensory-motor integration is one of the key issues in robotics. In this paper, we propose an approach to rhythmic arm movement control that is synchronized with an external signal based on exploiting a simple neural oscillator network. Trajectory generation by the neural oscillator is a biologically inspired method that can allow us to generate a smooth and continuous trajectory. The parameter tuning of the oscillators is used to generate a synchronized movement with wide intervals. We adopted the method for the drumming task as an example task. By using this method, the robot can realize synchronized drumming with wide drumming intervals in real time. The paper also shows the experimental results of drumming by a humanoid robot.

am

link (url) [BibTex]

link (url) [BibTex]


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Analysis of Gene Expression Data with Pathway Scores

Zien, A., Küffner, R., Zimmer, R., Lengauer, T.

In ISMB 2000, pages: 407-417, AAAI Press, Menlo Park, CA, USA, 8th International Conference on Intelligent Systems for Molecular Biology, August 2000 (inproceedings)

Abstract
We present a new approach for the evaluation of gene expression data. The basic idea is to generate biologically possible pathways and to score them with respect to gene expression measurements. We suggest sample scoring functions for different problem specifications. The significance of the scores for the investigated pathways is assessed by comparison to a number of scores for random pathways. We show that simple scoring functions can assign statistically significant scores to biologically relevant pathways. This suggests that the combination of appropriate scoring functions with the systematic generation of pathways can be used in order to select the most interesting pathways based on gene expression measurements.

ei

PDF [BibTex]

PDF [BibTex]


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A Meanfield Approach to the Thermodynamics of a Protein-Solvent System with Application to the Oligomerization of the Tumour Suppressor p53.

Noolandi, J., Davison, TS., Vokel, A., Nie, F., Kay, C., Arrowsmith, C.

Proceedings of the National Academy of Sciences of the United States of America, 97(18):9955-9960, August 2000 (article)

ei

Web [BibTex]

Web [BibTex]


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Observational Learning with Modular Networks

Shin, H., Lee, H., Cho, S.

In Lecture Notes in Computer Science (LNCS 1983), LNCS 1983, pages: 126-132, Springer-Verlag, Heidelberg, International Conference on Intelligent Data Engineering and Automated Learning (IDEAL), July 2000 (inproceedings)

Abstract
Observational learning algorithm is an ensemble algorithm where each network is initially trained with a bootstrapped data set and virtual data are generated from the ensemble for training. Here we propose a modular OLA approach where the original training set is partitioned into clusters and then each network is instead trained with one of the clusters. Networks are combined with different weighting factors now that are inversely proportional to the distance from the input vector to the cluster centers. Comparison with bagging and boosting shows that the proposed approach reduces generalization error with a smaller number of networks employed.

ei

PDF [BibTex]

PDF [BibTex]


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The Infinite Gaussian Mixture Model

Rasmussen, CE.

In Advances in Neural Information Processing Systems 12, pages: 554-560, (Editors: Solla, S.A. , T.K. Leen, K-R Müller), MIT Press, Cambridge, MA, USA, Thirteenth Annual Neural Information Processing Systems Conference (NIPS), June 2000 (inproceedings)

Abstract
In a Bayesian mixture model it is not necessary a priori to limit the number of components to be finite. In this paper an infinite Gaussian mixture model is presented which neatly sidesteps the difficult problem of finding the ``right'' number of mixture components. Inference in the model is done using an efficient parameter-free Markov Chain that relies entirely on Gibbs sampling.

ei

PDF Web [BibTex]

PDF Web [BibTex]


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Generalization Abilities of Ensemble Learning Algorithms

Shin, H., Jang, M., Cho, S.

In Proc. of the Korean Brain Society Conference, pages: 129-133, Korean Brain Society Conference, June 2000 (inproceedings)

ei

[BibTex]

[BibTex]


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Support vector method for novelty detection

Schölkopf, B., Williamson, R., Smola, A., Shawe-Taylor, J., Platt, J.

In Advances in Neural Information Processing Systems 12, pages: 582-588, (Editors: SA Solla and TK Leen and K-R Müller), MIT Press, Cambridge, MA, USA, 13th Annual Neural Information Processing Systems Conference (NIPS), June 2000 (inproceedings)

Abstract
Suppose you are given some dataset drawn from an underlying probability distribution ¤ and you want to estimate a “simple” subset ¥ of input space such that the probability that a test point drawn from ¤ lies outside of ¥ equals some a priori specified ¦ between § and ¨. We propose a method to approach this problem by trying to estimate a function © which is positive on ¥ and negative on the complement. The functional form of © is given by a kernel expansion in terms of a potentially small subset of the training data; it is regularized by controlling the length of the weight vector in an associated feature space. We provide a theoretical analysis of the statistical performance of our algorithm. The algorithm is a natural extension of the support vector algorithm to the case of unlabelled data.

ei

PDF Web [BibTex]

PDF Web [BibTex]


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v-Arc: Ensemble Learning in the Presence of Outliers

Rätsch, G., Schölkopf, B., Smola, A., Müller, K., Onoda, T., Mika, S.

In Advances in Neural Information Processing Systems 12, pages: 561-567, (Editors: SA Solla and TK Leen and K-R Müller), MIT Press, Cambridge, MA, USA, 13th Annual Neural Information Processing Systems Conference (NIPS), June 2000 (inproceedings)

Abstract
AdaBoost and other ensemble methods have successfully been applied to a number of classification tasks, seemingly defying problems of overfitting. AdaBoost performs gradient descent in an error function with respect to the margin, asymptotically concentrating on the patterns which are hardest to learn. For very noisy problems, however, this can be disadvantageous. Indeed, theoretical analysis has shown that the margin distribution, as opposed to just the minimal margin, plays a crucial role in understanding this phenomenon. Loosely speaking, some outliers should be tolerated if this has the benefit of substantially increasing the margin on the remaining points. We propose a new boosting algorithm which allows for the possibility of a pre-specified fraction of points to lie in the margin area or even on the wrong side of the decision boundary.

ei

PDF Web [BibTex]

PDF Web [BibTex]


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Invariant feature extraction and classification in kernel spaces

Mika, S., Rätsch, G., Weston, J., Schölkopf, B., Smola, A., Müller, K.

In Advances in neural information processing systems 12, pages: 526-532, (Editors: SA Solla and TK Leen and K-R Müller), MIT Press, Cambridge, MA, USA, 13th Annual Neural Information Processing Systems Conference (NIPS), June 2000 (inproceedings)

ei

PDF Web [BibTex]

PDF Web [BibTex]


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Transductive Inference for Estimating Values of Functions

Chapelle, O., Vapnik, V., Weston, J.

In Advances in Neural Information Processing Systems 12, pages: 421-427, (Editors: Solla, S.A. , T.K. Leen, K-R Müller), MIT Press, Cambridge, MA, USA, Thirteenth Annual Neural Information Processing Systems Conference (NIPS), June 2000 (inproceedings)

Abstract
We introduce an algorithm for estimating the values of a function at a set of test points $x_1^*,dots,x^*_m$ given a set of training points $(x_1,y_1),dots,(x_ell,y_ell)$ without estimating (as an intermediate step) the regression function. We demonstrate that this direct (transductive) way for estimating values of the regression (or classification in pattern recognition) is more accurate than the traditional one based on two steps, first estimating the function and then calculating the values of this function at the points of interest.

ei

PDF Web [BibTex]

PDF Web [BibTex]


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The entropy regularization information criterion

Smola, A., Shawe-Taylor, J., Schölkopf, B., Williamson, R.

In Advances in Neural Information Processing Systems 12, pages: 342-348, (Editors: SA Solla and TK Leen and K-R Müller), MIT Press, Cambridge, MA, USA, 13th Annual Neural Information Processing Systems Conference (NIPS), June 2000 (inproceedings)

Abstract
Effective methods of capacity control via uniform convergence bounds for function expansions have been largely limited to Support Vector machines, where good bounds are obtainable by the entropy number approach. We extend these methods to systems with expansions in terms of arbitrary (parametrized) basis functions and a wide range of regularization methods covering the whole range of general linear additive models. This is achieved by a data dependent analysis of the eigenvalues of the corresponding design matrix.

ei

PDF Web [BibTex]

PDF Web [BibTex]