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2017


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Biohybrid actuators for robotics: A review of devices actuated by living cells

Ricotti, L., Trimmer, B., Feinberg, A. W., Raman, R., Parker, K. K., Bashir, R., Sitti, M., Martel, S., Dario, P., Menciassi, A.

Science Robotics, 2(12), Science Robotics, November 2017 (article)

Abstract
Actuation is essential for artificial machines to interact with their surrounding environment and to accomplish the functions for which they are designed. Over the past few decades, there has been considerable progress in developing new actuation technologies. However, controlled motion still represents a considerable bottleneck for many applications and hampers the development of advanced robots, especially at small length scales. Nature has solved this problem using molecular motors that, through living cells, are assembled into multiscale ensembles with integrated control systems. These systems can scale force production from piconewtons up to kilonewtons. By leveraging the performance of living cells and tissues and directly interfacing them with artificial components, it should be possible to exploit the intricacy and metabolic efficiency of biological actuation within artificial machines. We provide a survey of important advances in this biohybrid actuation paradigm.

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link (url) DOI [BibTex]

2017


link (url) DOI [BibTex]


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Online Learning with Stochastic Recurrent Neural Networks using Intrinsic Motivation Signals

Tanneberg, D., Peters, J., Rueckert, E.

Proceedings of the 1st Annual Conference on Robot Learning (CoRL), pages: 167-174, Proceedings of Machine Learning Research, (Editors: Sergey Levine, Vincent Vanhoucke and Ken Goldberg), PMLR, November 2017 (conference)

ei

link (url) Project Page [BibTex]

link (url) Project Page [BibTex]


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Behind Distribution Shift: Mining Driving Forces of Changes and Causal Arrows

Huang, B., Zhang, K., Zhang, J., Sanchez-Romero, R., Glymour, C., Schölkopf, B.

IEEE 17th International Conference on Data Mining (ICDM), pages: 913-918, (Editors: Vijay Raghavan,Srinivas Aluru, George Karypis, Lucio Miele and Xindong Wu), November 2017 (conference)

ei

DOI [BibTex]

DOI [BibTex]


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Efficient Online Adaptation with Stochastic Recurrent Neural Networks

Tanneberg, D., Peters, J., Rueckert, E.

IEEE-RAS 17th International Conference on Humanoid Robotics (Humanoids), pages: 198-204, IEEE, November 2017 (conference)

ei

DOI Project Page [BibTex]

DOI Project Page [BibTex]


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Probabilistic Line Searches for Stochastic Optimization

Mahsereci, M., Hennig, P.

Journal of Machine Learning Research, 18(119):1-59, November 2017 (article)

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link (url) Project Page [BibTex]

link (url) Project Page [BibTex]


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Learning inverse dynamics models in O(n) time with LSTM networks

Rueckert, E., Nakatenus, M., Tosatto, S., Peters, J.

IEEE-RAS 17th International Conference on Humanoid Robotics (Humanoids), pages: 811-816, IEEE, November 2017 (conference)

ei

DOI Project Page [BibTex]

DOI Project Page [BibTex]


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A Comparison of Distance Measures for Learning Nonparametric Motor Skill Libraries

Stark, S., Peters, J., Rueckert, E.

IEEE-RAS 17th International Conference on Humanoid Robotics (Humanoids), pages: 624-630, IEEE, November 2017 (conference)

ei

DOI Project Page [BibTex]

DOI Project Page [BibTex]


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Simulation of the underactuated Sake Robotics Gripper in V-REP

Thiem, S., Stark, S., Tanneberg, D., Peters, J., Rueckert, E.

Workshop at the International Conference on Humanoid Robots (HUMANOIDS), November 2017 (conference)

ei

link (url) [BibTex]

link (url) [BibTex]


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End-to-End Learning for Image Burst Deblurring

Wieschollek, P., Schölkopf, B., Lensch, H. P. A., Hirsch, M.

Computer Vision - ACCV 2016 - 13th Asian Conference on Computer Vision, 10114, pages: 35-51, Image Processing, Computer Vision, Pattern Recognition, and Graphics, (Editors: Lai, S.-H., Lepetit, V., Nishino, K., and Sato, Y. ), Springer, November 2017 (conference)

ei

[BibTex]

[BibTex]


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Active Incremental Learning of Robot Movement Primitives

Maeda, G., Ewerton, M., Osa, T., Busch, B., Peters, J.

Proceedings of the 1st Annual Conference on Robot Learning (CoRL), 78, pages: 37-46, Proceedings of Machine Learning Research, (Editors: Sergey Levine, Vincent Vanhoucke and Ken Goldberg), PMLR, November 2017 (conference)

ei

link (url) Project Page [BibTex]

link (url) Project Page [BibTex]


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Online Video Deblurring via Dynamic Temporal Blending Network

Kim, T. H., Lee, K. M., Schölkopf, B., Hirsch, M.

Proceedings IEEE International Conference on Computer Vision (ICCV), pages: 4038-4047, IEEE, Piscataway, NJ, USA, IEEE International Conference on Computer Vision (ICCV), October 2017 (conference)

ei

link (url) [BibTex]

link (url) [BibTex]


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EnhanceNet: Single Image Super-Resolution through Automated Texture Synthesis

Sajjadi, M. S. M., Schölkopf, B., Hirsch, M.

Proceedings IEEE International Conference on Computer Vision (ICCV), pages: 4501-4510, IEEE, Piscataway, NJ, USA, IEEE International Conference on Computer Vision (ICCV), October 2017 (conference)

ei

Arxiv Project link (url) DOI [BibTex]

Arxiv Project link (url) DOI [BibTex]


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Learning Blind Motion Deblurring

Wieschollek, P., Hirsch, M., Schölkopf, B., Lensch, H.

Proceedings IEEE International Conference on Computer Vision (ICCV), pages: 231-240, IEEE, Piscataway, NJ, USA, IEEE International Conference on Computer Vision (ICCV), October 2017 (conference)

ei

link (url) [BibTex]

link (url) [BibTex]


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Personalized Brain-Computer Interface Models for Motor Rehabilitation

Mastakouri, A., Weichwald, S., Ozdenizci, O., Meyer, T., Schölkopf, B., Grosse-Wentrup, M.

Proceedings of the IEEE International Conference on Systems, Man, and Cybernetics (SMC), pages: 3024-3029, October 2017 (conference)

ei

ArXiv PDF DOI Project Page [BibTex]

ArXiv PDF DOI Project Page [BibTex]


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Improving performance of linear field generation with multi-coil setup by optimizing coils position

Aghaeifar, A., Loktyushin, A., Eschelbach, M., Scheffler, K.

Magnetic Resonance Materials in Physics, Biology and Medicine, 30(Supplement 1):S259, 34th Annual Scientific Meeting of the European Society for Magnetic Resonance in Medicine and Biology (ESMRMB), October 2017 (poster)

ei

link (url) DOI [BibTex]

link (url) DOI [BibTex]


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Generalized exploration in policy search

van Hoof, H., Tanneberg, D., Peters, J.

Machine Learning, 106(9-10):1705-1724 , (Editors: Kurt Driessens, Dragi Kocev, Marko Robnik‐Sikonja, and Myra Spiliopoulou), October 2017, Special Issue of the ECML PKDD 2017 Journal Track (article)

ei

DOI Project Page [BibTex]

DOI Project Page [BibTex]


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Multi-frame blind image deconvolution through split frequency - phase recovery

Gauci, A., Abela, J., Cachia, E., Hirsch, M., ZarbAdami, K.

Proc. SPIE 10225, Eighth International Conference on Graphic and Image Processing (ICGIP 2016), pages: 1022511, (Editors: Yulin Wang, Tuan D. Pham, Vit Vozenilek, David Zhang, Yi Xie), October 2017 (conference)

ei

DOI [BibTex]

DOI [BibTex]


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Probabilistic Prioritization of Movement Primitives

Paraschos, A., Lioutikov, R., Peters, J., Neumann, G.

Proceedings of the International Conference on Intelligent Robot Systems, and IEEE Robotics and Automation Letters (RA-L), 2(4):2294-2301, October 2017 (article)

ei

link (url) DOI [BibTex]

link (url) DOI [BibTex]


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Editorial for the Special Issue on Microdevices and Microsystems for Cell Manipulation

Hu, W., Ohta, A. T.

8, Multidisciplinary Digital Publishing Institute, September 2017 (misc)

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DOI [BibTex]

DOI [BibTex]


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Multifunctional Bacteria-Driven Microswimmers for Targeted Active Drug Delivery

Park, B., Zhuang, J., Yasa, O., Sitti, M.

ACS Nano, 11(9):8910-8923, September 2017, PMID: 28873304 (article)

Abstract
High-performance, multifunctional bacteria-driven microswimmers are introduced using an optimized design and fabrication method for targeted drug delivery applications. These microswimmers are made of mostly single Escherichia coli bacterium attached to the surface of drug-loaded polyelectrolyte multilayer (PEM) microparticles with embedded magnetic nanoparticles. The PEM drug carriers are 1 μm in diameter and are intentionally fabricated with a more viscoelastic material than the particles previously studied in the literature. The resulting stochastic microswimmers are able to swim at mean speeds of up to 22.5 μm/s. They can be guided and targeted to specific cells, because they exhibit biased and directional motion under a chemoattractant gradient and a magnetic field, respectively. Moreover, we demonstrate the microswimmers delivering doxorubicin anticancer drug molecules, encapsulated in the polyelectrolyte multilayers, to 4T1 breast cancer cells under magnetic guidance in vitro. The results reveal the feasibility of using these active multifunctional bacteria-driven microswimmers to perform targeted drug delivery with significantly enhanced drug transfer, when compared with the passive PEM microparticles.

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link (url) DOI Project Page [BibTex]


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EndoSensorFusion: Particle Filtering-Based Multi-sensory Data Fusion with Switching State-Space Model for Endoscopic Capsule Robots

Turan, M., Almalioglu, Y., Gilbert, H., Araujo, H., Cemgil, T., Sitti, M.

ArXiv e-prints, September 2017 (article)

Abstract
A reliable, real time multi-sensor fusion functionality is crucial for localization of actively controlled capsule endoscopy robots, which are an emerging, minimally invasive diagnostic and therapeutic technology for the gastrointestinal (GI) tract. In this study, we propose a novel multi-sensor fusion approach based on a particle filter that incorporates an online estimation of sensor reliability and a non-linear kinematic model learned by a recurrent neural network. Our method sequentially estimates the true robot pose from noisy pose observations delivered by multiple sensors. We experimentally test the method using 5 degree-of-freedom (5-DoF) absolute pose measurement by a magnetic localization system and a 6-DoF relative pose measurement by visual odometry. In addition, the proposed method is capable of detecting and handling sensor failures by ignoring corrupted data, providing the robustness expected of a medical device. Detailed analyses and evaluations are presented using ex-vivo experiments on a porcine stomach model prove that our system achieves high translational and rotational accuracies for different types of endoscopic capsule robot trajectories.

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link (url) Project Page [BibTex]


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Endo-VMFuseNet: Deep Visual-Magnetic Sensor Fusion Approach for Uncalibrated, Unsynchronized and Asymmetric Endoscopic Capsule Robot Localization Data

Turan, M., Almalioglu, Y., Gilbert, H., Eren Sari, A., Soylu, U., Sitti, M.

ArXiv e-prints, September 2017 (article)

Abstract
In the last decade, researchers and medical device companies have made major advances towards transforming passive capsule endoscopes into active medical robots. One of the major challenges is to endow capsule robots with accurate perception of the environment inside the human body, which will provide necessary information and enable improved medical procedures. We extend the success of deep learning approaches from various research fields to the problem of uncalibrated, asynchronous, and asymmetric sensor fusion for endoscopic capsule robots. The results performed on real pig stomach datasets show that our method achieves sub-millimeter precision for both translational and rotational movements and contains various advantages over traditional sensor fusion techniques.

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link (url) Project Page [BibTex]


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Magnetotactic Bacteria Powered Biohybrids Target E. coli Biofilms

Stanton, M. M., Park, B., Vilela, D., Bente, K., Faivre, D., Sitti, M., Sánchez, S.

ACS Nano, 0(0):null, September 2017, PMID: 28933815 (article)

Abstract
Biofilm colonies are typically resistant to general antibiotic treatment and require targeted methods for their removal. One of these methods includes the use of nanoparticles as carriers for antibiotic delivery, where they randomly circulate in fluid until they make contact with the infected areas. However, the required proximity of the particles to the biofilm results in only moderate efficacy. We demonstrate here that the nonpathogenic magnetotactic bacteria Magnetosopirrillum gryphiswalense (MSR-1) can be integrated with drug-loaded mesoporous silica microtubes to build controllable microswimmers (biohybrids) capable of antibiotic delivery to target an infectious biofilm. Applying external magnetic guidance capability and swimming power of the MSR-1 cells, the biohybrids are directed to and forcefully pushed into matured Escherichia coli (E. coli) biofilms. Release of the antibiotic, ciprofloxacin, is triggered by the acidic microenvironment of the biofilm, ensuring an efficient drug delivery system. The results reveal the capabilities of a nonpathogenic bacteria species to target and dismantle harmful biofilms, indicating biohybrid systems have great potential for antibiofilm applications.

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link (url) DOI Project Page [BibTex]

link (url) DOI Project Page [BibTex]


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Closing One’s Eyes Affects Amplitude Modulation but Not Frequency Modulation in a Cognitive BCI

Görner, M., Schölkopf, B., Grosse-Wentrup, M.

Proceedings of the 7th Graz Brain-Computer Interface Conference 2017 - From Vision to Reality, pages: 165-170, (Editors: Müller-Putz G.R., Steyrl D., Wriessnegger S. C., Scherer R.), Graz University of Technology, Austria, Graz Brain-Computer Interface Conference, September 2017 (conference)

ei

DOI [BibTex]

DOI [BibTex]


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A Guided Task for Cognitive Brain-Computer Interfaces

Moser, J., Hohmann, M. R., Schölkopf, B., Grosse-Wentrup, M.

Proceedings of the 7th Graz Brain-Computer Interface Conference 2017 - From Vision to Reality, pages: 326-331, (Editors: Müller-Putz G.R., Steyrl D., Wriessnegger S. C., Scherer R.), Graz University of Technology, Austria, Graz Brain-Computer Interface Conference, September 2017 (conference)

ei

DOI [BibTex]

DOI [BibTex]


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Bayesian Regression for Artifact Correction in Electroencephalography

Fiebig, K., Jayaram, V., Hesse, T., Blank, A., Peters, J., Grosse-Wentrup, M.

Proceedings of the 7th Graz Brain-Computer Interface Conference 2017 - From Vision to Reality, pages: 131-136, (Editors: Müller-Putz G.R., Steyrl D., Wriessnegger S. C., Scherer R.), Graz University of Technology, Austria, Graz Brain-Computer Interface Conference, September 2017 (conference)

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DOI [BibTex]

DOI [BibTex]


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Investigating Music Imagery as a Cognitive Paradigm for Low-Cost Brain-Computer Interfaces

Grossberger, L., Hohmann, M. R., Peters, J., Grosse-Wentrup, M.

Proceedings of the 7th Graz Brain-Computer Interface Conference 2017 - From Vision to Reality, pages: 160-164, (Editors: Müller-Putz G.R., Steyrl D., Wriessnegger S. C., Scherer R.), Graz University of Technology, Austria, Graz Brain-Computer Interface Conference, September 2017 (conference)

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DOI [BibTex]

DOI [BibTex]


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Correlations of Motor Adaptation Learning and Modulation of Resting-State Sensorimotor EEG Activity

Ozdenizci, O., Yalcin, M., Erdogan, A., Patoglu, V., Grosse-Wentrup, M., Cetin, M.

Proceedings of the 7th Graz Brain-Computer Interface Conference 2017 - From Vision to Reality, pages: 384-388, (Editors: Müller-Putz G.R., Steyrl D., Wriessnegger S. C., Scherer R.), Graz University of Technology, Austria, Graz Brain-Computer Interface Conference, September 2017 (conference)

ei

DOI [BibTex]

DOI [BibTex]


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Weakly-Supervised Localization of Diabetic Retinopathy Lesions in Retinal Fundus Images

Gondal, M. W., Köhler, J. M., Grzeszick, R., Fink, G., Hirsch, M.

IEEE International Conference on Image Processing (ICIP), pages: 2069-2073, September 2017 (conference)

ei

arXiv DOI [BibTex]

arXiv DOI [BibTex]


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Assisting the practice of motor skills by humans with a probability distribution over trajectories

Ewerton, M., Maeda, G., Rother, D., Weimar, J., Lotter, L., Kollegger, G., Wiemeyer, J., Peters, J.

In Workshop Human-in-the-loop robotic manipulation: on the influence of the human role at IROS, September 2017 (inproceedings)

ei

link (url) [BibTex]

link (url) [BibTex]


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BIMROB – Bidirectional Interaction Between Human and Robot for the Learning of Movements

Kollegger, G., Ewerton, M., Wiemeyer, J., Peters, J.

Proceedings of the 11th International Symposium on Computer Science in Sport (IACSS), (663):151-163, Advances in Intelligent Systems and Computing, (Editors: Lames M., Saupe D. and Wiemeyer J.), Springer International Publishing, September 2017 (conference)

ei

DOI [BibTex]

DOI [BibTex]


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Goal-driven dimensionality reduction for reinforcement learning

Parisi, S., Ramstedt, S., Peters, J.

IEEE/RSJ International Conference on Intelligent Robots and Systems (IROS), pages: 4634-4639, IEEE, September 2017 (conference)

ei

DOI Project Page [BibTex]

DOI Project Page [BibTex]


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Swimming in low reynolds numbers using planar and helical flagellar waves

Khalil, I. S. M., Tabak, A. F., Seif, M. A., Klingner, A., Adel, B., Sitti, M.

In International Conference on Intelligent Robots and Systems (IROS) 2017, pages: 1907-1912, International Conference on Intelligent Robots and Systems, September 2017 (inproceedings)

Abstract
In travelling towards the oviducts, sperm cells undergo transitions between planar to helical flagellar propulsion by a beating tail based on the viscosity of the environment. In this work, we aim to model and mimic this behaviour in low Reynolds number fluids using externally actuated soft robotic sperms. We numerically investigate the effects of transition between planar to helical flagellar propulsion on the swimming characteristics of the robotic sperm using a model based on resistive-force theory to study the role of viscous forces on its flexible tail. Experimental results are obtained using robots that contain magnetic particles within the polymer matrix of its head and an ultra-thin flexible tail. The planar and helical flagellar propulsion are achieved using in-plane and out-of-plane uniform fields with sinusoidally varying components, respectively. We experimentally show that the swimming speed of the robotic sperm increases by a factor of 1.4 (fluid viscosity 5 Pa.s) when it undergoes a controlled transition between planar to helical flagellar propulsion, at relatively low actuation frequencies.

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DOI [BibTex]

DOI [BibTex]


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Hybrid control trajectory optimization under uncertainty

Pajarinen, J., Kyrki, V., Koval, M., Srinivasa, S., Peters, J., Neumann, G.

IEEE/RSJ International Conference on Intelligent Robots and Systems (IROS), pages: 5694-5701, September 2017 (conference)

ei

DOI Project Page [BibTex]

DOI Project Page [BibTex]


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Local Bayesian Optimization of Motor Skills

Akrour, R., Sorokin, D., Peters, J., Neumann, G.

Proceedings of the 34th International Conference on Machine Learning, 70, pages: 41-50, Proceedings of Machine Learning Research, (Editors: Doina Precup, Yee Whye Teh), PMLR, International Conference on Machine Learning (ICML), August 2017 (conference)

am ei

link (url) Project Page [BibTex]

link (url) Project Page [BibTex]


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Sequence Tutor: Conservative fine-tuning of sequence generation models with KL-control

Jaques, N., Gu, S., Bahdanau, D., Hernández-Lobato, J. M., Turner, R. E., Eck, D.

Proceedings of the 34th International Conference on Machine Learning, 70, pages: 1645-1654, Proceedings of Machine Learning Research, (Editors: Doina Precup, Yee Whye Teh), PMLR, International Conference on Machine Learning (ICML), August 2017 (conference)

ei

Arxiv link (url) Project Page [BibTex]

Arxiv link (url) Project Page [BibTex]


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Lost Relatives of the Gumbel Trick

Balog, M., Tripuraneni, N., Ghahramani, Z., Weller, A.

Proceedings of the 34th International Conference on Machine Learning, 70, pages: 371-379, Proceedings of Machine Learning Research, (Editors: Doina Precup, Yee Whye Teh), PMLR, International Conference on Machine Learning (ICML), August 2017 (conference)

ei

Code link (url) Project Page [BibTex]

Code link (url) Project Page [BibTex]


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Approximate Steepest Coordinate Descent

Stich, S., Raj, A., Jaggi, M.

Proceedings of the 34th International Conference on Machine Learning, 70, pages: 3251-3259, Proceedings of Machine Learning Research, (Editors: Doina Precup, Yee Whye Teh), PMLR, International Conference on Machine Learning (ICML), August 2017 (conference)

ei

link (url) Project Page [BibTex]

link (url) Project Page [BibTex]


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Sparse-then-Dense Alignment based 3D Map Reconstruction Method for Endoscopic Capsule Robots

Turan, M., Yigit Pilavci, Y., Ganiyusufoglu, I., Araujo, H., Konukoglu, E., Sitti, M.

ArXiv e-prints, August 2017 (article)

Abstract
Since the development of capsule endoscopcy technology, substantial progress were made in converting passive capsule endoscopes to robotic active capsule endoscopes which can be controlled by the doctor. However, robotic capsule endoscopy still has some challenges. In particular, the use of such devices to generate a precise and globally consistent three-dimensional (3D) map of the entire inner organ remains an unsolved problem. Such global 3D maps of inner organs would help doctors to detect the location and size of diseased areas more accurately, precisely, and intuitively, thus permitting more accurate and intuitive diagnoses. The proposed 3D reconstruction system is built in a modular fashion including preprocessing, frame stitching, and shading-based 3D reconstruction modules. We propose an efficient scheme to automatically select the key frames out of the huge quantity of raw endoscopic images. Together with a bundle fusion approach that aligns all the selected key frames jointly in a globally consistent way, a significant improvement of the mosaic and 3D map accuracy was reached. To the best of our knowledge, this framework is the first complete pipeline for an endoscopic capsule robot based 3D map reconstruction containing all of the necessary steps for a reliable and accurate endoscopic 3D map. For the qualitative evaluations, a real pig stomach is employed. Moreover, for the first time in literature, a detailed and comprehensive quantitative analysis of each proposed pipeline modules is performed using a non-rigid esophagus gastro duodenoscopy simulator, four different endoscopic cameras, a magnetically activated soft capsule robot (MASCE), a sub-millimeter precise optical motion tracker and a fine-scale 3D optical scanner.

pi

link (url) Project Page [BibTex]

link (url) Project Page [BibTex]


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Causal Consistency of Structural Equation Models

Rubenstein*, P. K., Weichwald*, S., Bongers, S., Mooij, J. M., Janzing, D., Grosse-Wentrup, M., Schölkopf, B.

Proceedings of the 33rd Conference on Uncertainty in Artificial Intelligence (UAI), (Editors: Gal Elidan, Kristian Kersting, and Alexander T. Ihler), Association for Uncertainty in Artificial Intelligence (AUAI), Conference on Uncertainty in Artificial Intelligence (UAI), August 2017, *equal contribution (conference)

ei

Arxiv PDF link (url) [BibTex]

Arxiv PDF link (url) [BibTex]


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Causal Discovery from Temporally Aggregated Time Series

Gong, M., Zhang, K., Schölkopf, B., Glymour, C., Tao, D.

Proceedings Conference on Uncertainty in Artificial Intelligence (UAI) 2017, pages: ID 269, (Editors: Gal Elidan, Kristian Kersting, and Alexander T. Ihler), Association for Uncertainty in Artificial Intelligence (AUAI), Conference on Uncertainty in Artificial Intelligence (UAI), August 2017 (conference)

ei

link (url) [BibTex]

link (url) [BibTex]


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Coupling Adaptive Batch Sizes with Learning Rates

Balles, L., Romero, J., Hennig, P.

In Proceedings Conference on Uncertainty in Artificial Intelligence (UAI) 2017, pages: 410-419, (Editors: Gal Elidan and Kristian Kersting), Association for Uncertainty in Artificial Intelligence (AUAI), Conference on Uncertainty in Artificial Intelligence (UAI), August 2017 (inproceedings)

Abstract
Mini-batch stochastic gradient descent and variants thereof have become standard for large-scale empirical risk minimization like the training of neural networks. These methods are usually used with a constant batch size chosen by simple empirical inspection. The batch size significantly influences the behavior of the stochastic optimization algorithm, though, since it determines the variance of the gradient estimates. This variance also changes over the optimization process; when using a constant batch size, stability and convergence is thus often enforced by means of a (manually tuned) decreasing learning rate schedule. We propose a practical method for dynamic batch size adaptation. It estimates the variance of the stochastic gradients and adapts the batch size to decrease the variance proportionally to the value of the objective function, removing the need for the aforementioned learning rate decrease. In contrast to recent related work, our algorithm couples the batch size to the learning rate, directly reflecting the known relationship between the two. On three image classification benchmarks, our batch size adaptation yields faster optimization convergence, while simultaneously simplifying learning rate tuning. A TensorFlow implementation is available.

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Code link (url) Project Page [BibTex]

Code link (url) Project Page [BibTex]


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Dipole codes attractively encode glue functions

Ipparthi, D., Mastrangeli, M., Winslow, A.

Theoretical Computer Science, 671, pages: 19 - 25, August 2017, Computational Self-Assembly (article)

Abstract
Dipole words are sequences of magnetic dipoles, in which alike elements repel and opposite elements attract. Magnetic dipoles contrast with more general sets of bonding types, called glues, in which pairwise bonding strength is specified by a glue function. We prove that every glue function g has a set of dipole words, called a dipole code, that attractively encodes g: the pairwise attractions (positive or non-positive bond strength) between the words are identical to those of g. Moreover, we give such word sets of asymptotically optimal length. Similar results are obtained for a commonly used subclass of glue functions.

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link (url) DOI [BibTex]

link (url) DOI [BibTex]


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Causal Discovery from Nonstationary/Heterogeneous Data: Skeleton Estimation and Orientation Determination

Zhang, K., Huang, B., Zhang, J., Glymour, C., Schölkopf, B.

Proceedings of the Twenty-Sixth International Joint Conference on Artificial Intelligence (IJCAI), pages: 1347-1353, (Editors: Carles Sierra), August 2017 (conference)

ei

PDF DOI [BibTex]

PDF DOI [BibTex]


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Hypoxia‐enhanced adhesion of red blood cells in microscale flow

Kim, M., Alapan, Y., Adhikari, A., Little, J. A., Gurkan, U. A.

Microcirculation, 24(5):e12374, July 2017 (article)

Abstract
Abstract Objectives The advancement of microfluidic technology has facilitated the simulation of physiological conditions of the microcirculation, such as oxygen tension, fluid flow, and shear stress in these devices. Here, we present a micro‐gas exchanger integrated with microfluidics to study RBC adhesion under hypoxic flow conditions mimicking postcapillary venules. Methods We simulated a range of physiological conditions and explored RBC adhesion to endothelial or subendothelial components (FN or LN). Blood samples were injected into microchannels at normoxic or hypoxic physiological flow conditions. Quantitative evaluation of RBC adhesion was performed on 35 subjects with homozygous SCD. Results Significant heterogeneity in RBC adherence response to hypoxia was seen among SCD patients. RBCs from a HEA population showed a significantly greater increase in adhesion compared to RBCs from a HNA population, for both FN and LN. Conclusions The approach presented here enabled the control of oxygen tension in blood during microscale flow and the quantification of RBC adhesion in a cost‐efficient and patient‐specific manner. We identified a unique patient population in which RBCs showed enhanced adhesion in hypoxia in vitro. Clinical correlates suggest a more severe clinical phenotype in this subgroup.

pi

link (url) DOI [BibTex]

link (url) DOI [BibTex]


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An XY ϴz flexure mechanism with optimal stiffness properties

Lum, G. Z., Pham, M. T., Teo, T. J., Yang, G., Yeo, S. H., Sitti, M.

In 2017 IEEE International Conference on Advanced Intelligent Mechatronics (AIM), pages: 1103-1110, July 2017 (inproceedings)

Abstract
The development of optimal XY θz flexure mechanisms, which can deliver high precision motion about the z-axis, and along the x- and y-axes is highly desirable for a wide range of micro/nano-positioning tasks pertaining to biomedical research, microscopy technologies and various industrial applications. Although maximizing the stiffness ratios is a very critical design requirement, the achievable translational and rotational stiffness ratios of existing XY θz flexure mechanisms are still restricted between 0.5 and 130. As a result, these XY θz flexure mechanisms are unable to fully optimize their workspace and capabilities to reject disturbances. Here, we present an optimal XY θz flexure mechanism, which is designed to have maximum stiffness ratios. Based on finite element analysis (FEA), it has translational stiffness ratio of 248, rotational stiffness ratio of 238 and a large workspace of 2.50 mm × 2.50 mm × 10°. Despite having such a large workspace, FEA also predicts that the proposed mechanism can still achieve a high bandwidth of 70 Hz. In comparison, the bandwidth of similar existing flexure mechanisms that can deflect more than 0.5 mm or 0.5° is typically less than 45 Hz. Hence, the high stiffness ratios of the proposed mechanism are achieved without compromising its dynamic performance. Preliminary experimental results pertaining to the mechanism's translational actuating stiffness and bandwidth were in agreement with the FEA predictions as the deviation was within 10%. In conclusion, the proposed flexure mechanism exhibits superior performance and can be used across a wide range of applications.

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DOI [BibTex]

DOI [BibTex]


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Positioning of drug carriers using permanent magnet-based robotic system in three-dimensional space

Khalil, I. S. M., Alfar, A., Tabak, A. F., Klingner, A., Stramigioli, S., Sitti, M.

In 2017 IEEE International Conference on Advanced Intelligent Mechatronics (AIM), pages: 1117-1122, July 2017 (inproceedings)

Abstract
Magnetic control of drug carriers using systems with open-configurations is essential to enable scaling to the size of in vivo applications. In this study, we demonstrate motion control of paramagnetic microparticles in a low Reynolds number fluid, using a permanent magnet-based robotic system with an open-configuration. The microparticles are controlled in three-dimensional (3D) space using a cylindrical NdFeB magnet that is fixed to the end-effector of a robotic arm. We develop a kinematic map between the position of the microparticles and the configuration of the robotic arm, and use this map as a basis of a closed-loop control system based on the position of the microparticles. Our experimental results show the ability of the robot configuration to control the exerted field gradient on the dipole of the microparticles, and achieve positioning in 3D space with maximum error of 300 µm and 600 µm in the steady-state during setpoint and trajectory tracking, respectively.

pi

DOI [BibTex]

DOI [BibTex]


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Self-assembly of micro/nanosystems across scales and interfaces

Mastrangeli, M.

In 2017 19th International Conference on Solid-State Sensors, Actuators and Microsystems (TRANSDUCERS), pages: 676 - 681, IEEE, July 2017 (inproceedings)

Abstract
Steady progress in understanding and implementation are establishing self-assembly as a versatile, parallel and scalable approach to the fabrication of transducers. In this contribution, I illustrate the principles and reach of self-assembly with three applications at different scales - namely, the capillary self-alignment of millimetric components, the sealing of liquid-filled polymeric microcapsules, and the accurate capillary assembly of single nanoparticles - and propose foreseeable directions for further developments.

pi

link (url) DOI [BibTex]

link (url) DOI [BibTex]


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Flexible Spatio-Temporal Networks for Video Prediction

Lu, C., Hirsch, M., Schölkopf, B.

Proceedings IEEE Conference on Computer Vision and Pattern Recognition (CVPR) 2017, pages: 2137-2145, IEEE, Piscataway, NJ, USA, IEEE Conference on Computer Vision and Pattern Recognition (CVPR), July 2017 (conference)

ei

link (url) DOI [BibTex]

link (url) DOI [BibTex]


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Discovering Causal Signals in Images

Lopez-Paz, D., Nishihara, R., Chintala, S., Schölkopf, B., Bottou, L.

Proceedings IEEE Conference on Computer Vision and Pattern Recognition (CVPR) 2017, pages: 58-66, IEEE, Piscataway, NJ, USA, IEEE Conference on Computer Vision and Pattern Recognition (CVPR), July 2017 (conference)

ei

link (url) DOI [BibTex]

link (url) DOI [BibTex]