Publikationen Forschungsgruppe Kemkemer


Greiner AM, Chen H, Spatz JP, Kemkemer R. Cyclic tensile strain controls cell shape and directs actin stress fiber formation and focal adhesion alignment in spreading cells. PLoS One. 2013 Oct 28;8(10):e77328.

M. Tönjes, S. Barbus, Y.-J. Park, W. Wang, M. Schlotter, A. Lindroth, S. Pleier, H.C. Bai, D. Karra, J. Felsberg, D. Lemke, V. Hovestadt, C. Rolli, R. Kemkemer, K. Schmidt, W. Hull, S.M. Hutson, S. Pfister, C. Plass, J.G. Okun, G. Reifenberger, P. Lichter, B. Radlwimmer. BCAT1 promotes cell proliferation through amino acid catabolism in gliomas carrying wild-type IDH1. Nature Medicine 2013 Jul;19(7):901-8. doi: 10.1038/nm.3217. Epub 2013 Jun 23.

Shiva Rudraraju, Kristen L. Mills, Ralf Kemkemer, and Krishna Garikipati: Multiphysics Modeling of Reactions, Mass Transport and Mechanics of Tumor Growth; in Computer Models in Biomechanics - From Nano to Macro, 2013, pp 293-303

A. Carisey, A. M. Greiner, R. Tsang, N. Nijenhuis, N. Heath, A. Nazgiewicz, R. Kemkemer, B. Derby, J. Spatz, C. Ballestrem. Vinculin governs a network of focal adhesion proteins in a force dependent manner. Current Biology 2013 Feb 18;23(4):271-81. doi: 10.1016/j.cub.2013.01.009. Epub 2013 Jan 31.


Deibler, M., Avci, A., Ehlers, W., Markert, B. & Kemkemer, R.: Dynamics of mechanically induced cytoskeleton reorganisation: Experimental study and mechanical modelling. Proceedings of the 3rd GAMM Seminar on Continuum Biomechanics. 2012, pp. 89–104

M. B. Chen, R. Kemkemer, M. Deibler, J. Spatz, H. Gao. Cyclic stretch induces cell reorientation by destabilizing catch bonds in focal adhesions. PLoS ONE 7(11): e48346. doi:10.1371/journal.pone.0048346 (2012)

B. Huck, R. Kemkemer, M. Franz-Wachtel, B. Macek, A. Hausser, and M.A. Olayioye. GIT1 phosphorylation on serine 46 by PKD3 regulates paxillin trafficking and cellular protrusive activity. Journal of Biological Chemistry, 2012; DOI:10.1074/jbc.M112.374652

Kaufmann, D., Hoesch, J., Su, Y., Deeg, L., Mellert, K., Spatz, J.P., Kemkemer, R.. Partial Blindness to Submicron Topography in NF1 Haploinsufficient Cultured Fibroblasts Indicates a New Function of Neurofibromin in Regulation of Mechanosensoric. Mol Syndromol 2012, DOI:10.1159/000342698

C. G. Rolli, H. Nakayama, K. Yamaguchi, J.P. Spatz, J. Nakanishi* and R. Kemkemer* (*contributed equally). Switchable adhesive substrates: Revealing geometry dependence in collective cell behavior. Biomaterials. 33, 2409-18, (2012)

A. Bai, T. Milde, M. Remke, C.G. Rolli, T. Hielscher, Y. Cho, M. Kool, P.A. Northcott, M. Jugold, A.V. Bahzin, S.B. Eichmueller, A.E. Kulozik, A. Pscherer, A. Benner, M.D. Taylor S.L. Pomeroy, R. Kemkemer, O. Witt, A. Korshunov, P. Lichter, and S.M. Pfister. MicroRNA-182 promotes metastatic dissemination of non-sonic hedgehog-medulloblastoma. Acta Neuropathol., 123:529-38 (2012)


Michael Uhl, Kevin Mellert, Britta Striegl, Martin Deibler, Markus Lamla, Joachim P Spatz, Ralf Kemkemer, and Dieter Kaufmann. Cyclic stretch increases splicing noise rate in cultured human fibroblasts. BMC Research Notes (2011), 4:470 

M. Deibler, J.P. Spatz, R. Kemkemer. Actin fusion proteins alter the dynamics of mechanically induced cytoskeleton rearrangement. PLoS One. 2011; 6(8): e22941.

J.T. Zahn, I. Louban, S. Jungbauer, M. Bissinger, D. Kaufmann, R. Kemkemer (corresponding author), J.P. Spatz. Age-dependent changes in micro-scale stiffness and mechano-responses of cells.
SMALL, (2011), 7(10):1480-7.

K. Mellert, M. Uhl, J. Högel, M. Lamla, R. Kemkemer and D. Kaufmann. Aberrant Single Exon Skipping is not Altered by Age in Exons of NF1, RABAC1, AATF or PCGF2 in Human Blood Cells and Fibroblasts. Genes, 2011, 2(3), 562-577; doi:10.3390/genes2030562

E. Wörtche, M. Deibler, S. Schulz, T. Steinberg, R. Kemkemer (corresponding author), P. Tomakidi Kinetic fingerprint of two periodontal cell populations subjected to uni-axial cyclic tensile strain
Soft Matter, (2011), 7, 8612-8618. 

D. Kaufmann, Yi Su, S. Biela, S. Jungbauer, J. P. Spatz, R. Kemkemer. Soft lithography detects partial mechano-sensoric blindness to micrometre topography in cultured aged and diseased cells.
IJMR102 (2011) 7, 896-902

K. L. Mills, K. Garikipati, R. Kemkemer Experimental characterization of tumor spheroids for studies of the energetics of tumor growth.
IJMR 102 (2011) 7, 889-895

D. Ambrosi, G.A. Ateshian, E.M. Arruda, S.C. Cowin, J. Dumais, A. Goriely, G.A. Holzapfel, J.D. Humphrey, R. Kemkemer, E. Kuhl, J.E. Olberding, L.A. Taber, K. Garikipati. Perspectives on biological growth and remodeling.
Journal of the Mechanics and Physics of Solids 59 (2011) 863–883


A.M. Goldyn, B. Aragüés Rioja, J.P. Spatz, C. Ballestrem and R. Kemkemer. The kinetics of force-induced cell reorganization depend on microtubules and actin.
Cytoskeleton, 2010, 67:241–250

H.G. Kilian, M. Kazda,, D. Kaufmann, R. Kemkemer and D. Bartkowiak. 
Symmetries of the Structure-Bounded Growth Process in Plant- Populations.
Cell Biochem Biophys (2010) 57:87–100

H Narayanan, S N Verner, K.L. Mills, R. Kemkemer and K. Garikipati. In silico estimates of the free energy rates in growing tumor spheroids.
Journal of Physics: Condensed Matter, 22, 194122, (2010)

Rolli CG, Seufferlein T, Kemkemer R*, Spatz JP. Impact of tumor cell cytoskeleton organization on invasiveness and migration: a microchannel-based approach.
PLoS One. 2010 Jan 15;5(1):e8726.

W. Ahmed, T. Wolfram, A. Goldyn, K. Bruellhoff, B. Aragüés Rioja, M. Möller, J.P. Spatz, T.A. Saif, J. Groll, R. Kemkemer. Myoblast morphology and organization on biochemically micro-patterned hydrogel coatings under cyclic mechanical strain.
Biomaterials. 2010, 31(2):250-8.


A.M. Goldyn, B. Aragüés Rioja, J.P. Spatz, C. Ballestrem and R. Kemkemer, Force-Induced Cell Polarisation is Linked to RhoA-Driven, Microtubule-Independent Focal Adhesion Sliding.
J. Cell Sci. 2009;122:3644-51.

S. Biela, S. Yi, J.P. Spatz, R. Kemkemer, Different sensitivity of EC and SMC to topography in the nano-micro range.
Acta Biomater. 2009;5(7):2460-6

S. Jungbauer, B. Aragües, J.P. Spatz, R. Kemkemer, Universal temporal response of fibroblasts under mechanical manipulation.
IUTAM Cellular, Molecular and Tissue Mechanics. Eds. Garikipati, K and Arruda, EM. Springer Publishing, 2009

Huang J, Gräter SV, Corbellini F, Rinck S, Bock E, Kemkemer R, Kessler H, Ding, J, Spatz JP., Impact of Order and Disorder in RGD Nanopatterns on Cell Adhesion.
Nano Letters 9, 1111-1116, (2009)


S. Jungbauer, H. Gao. JP Spatz, R. Kemkemer
. Two Characteristic Regimes in Frequency Dependent Dynamic Reorientation of Fibroblasts on Cyclically Stretched Substrates. 
Biophysical Journal. 95: 3470-3478, (2008)

H.G. Kilian, D. Bartkowiak, D. Kaufmann, R. Kemkemer. 
The general growth logistics of cell populations. 
Cell Biochem. Biophys. 51: 51-66 (2008)

selected publications before 2008

P.P. Girard, El. A. Cavalcanti-Adam, R. Kemkemer and J.P. Spatz.
 Cellular chemomechanics at interfaces: sensing, integration and response
Soft Matter (3),307-326 (2007)

Jungbauer, S; Kemkemer, R; Spatz, J. 
Dynamics of cell responses to mechanical stretching
Tissue Engineering 13:4 907-907 (2007)

R. Kemkemer, S. Jungbauer, D. Kaufmann, H. Gruler. 
Cell Orientation by a Microgrooved Substrate Can Be Predicted by Automatic Control Theory.
Biophys. J. 90: 4701-4711 (2006)

R. Kemkemer, G. Gomez Estrada, D. Kaufmann, D. Ulrich, H. Gruler
. Feature extraction of non-stained melanocyte cells
Biomedical Imaging and Processing. IEEE Signal Processing, 605-608, (2005)

S. Jungbauer, R. Kemkemer, D. Kaufmann, J. P. Spatz. 
Cell Shape Normalization, Dendrite Orientation and Melanin production of Normal and Genetically Altered (Haploinsufficient NF1)-Melanocytes by Microstructured Substrate Interactions. 
ChemPhysChem , 5, 85-92, (2004).

H.G. Kilian, R. Kemkemer, H. Gruler. 
Relaxation processes during cell growth.
Progr Colloid Polym Sci 125: 198–205(2004).

R. Kemkemer, H. Gruler, D. Kaufmann, J.P. Spatz
. Cell Shape Normalization of Normal and Haploinsufficient NF1-Melanocytes by Micro-Structured Substrate Interaction. 
In “Function and Regulation of Cellular Systems: Experiments and Models” (Mathematics and Biosciences in Interaction) , pp 185-199. Eds. A. Deutsch et al., Birkhäuser Verlag, Basel, (2003).

Kemkemer R, Csete M, Schrank S, Kaufmann D and Spatz J. 
The determination of the morphology of melanocytes by laser-generated periodic surface structures.
Materials Science and Engineering C 23-3, 437-440, (2003).

Kemkemer R, Schrank S, Vogel W, Gruler H, Kaufmann D.
 Increased noise as an effect of haploinsufficiency of the tumor suppressor gene Neurofibromatosis type 1 in vitro.

PNAS Proceedings of the National Academy of Science USA. 99(21), 13783-8, (2002).

Kilian HG, Kemkemer R, Gruler H.
Universality and individuality as complementary factors to optimize and reproduce cell populations.
Colloid Polym Sci 280, 1151 –1156, (2002).

Kaufmann D, Schrank S, Gruler H, Vogel W, Kemkemer R. 
Increased noise as an effect of haploinsufficiency of the tumor suppressor gene Neurofibromatosis type 1 in vitro.
American Journal Of Human Genetics 69 (4): 2349, Suppl. 1, (2001).

Kress M, Meier TH, El-Tayeb, TA, Kemkemer R, Steiner RW, Rueck AC. 
Short-pulsed diode lasers as an excitation source for time-resolved fluorescence applications and confocal laser scanning microscopy in PDT.
Proc. SPIE Vol. 4431, 108-113, (2001).

Kemkemer R, Teichgraber V, Schrank-Kaufmann S, Kaufmann D, Gruler H.
. Nematic order-disorder state transition in a liquid crystal analogue formed by oriented and migrating amoeboid cells. 
European Physical Journal E 3 (2): 101-110, (2000).

Kemkemer R, Kling D, Kaufmann D, Gruler H..
Elastic properties of nematoid arrangements formed by amoeboid cells. 
European Physical Journal E 1 (2-3): 215-225, (2000).

Kemkemer R, Neidlinger-Wilke C, Claes L, Gruler H. .
Cell orientation induced by extracellular signals. 
Cell Biochem. Biophys. 30(2):167-92, (1999).

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