Aktuelles & News

New Paper: Enhanced optical transmittance by reduced reflectance of curved polymer surfaces. W. Chen, Z. Diao, J. H. Dirks, F. Geiger, and J. Spatz (2017). Macromolecular Materials and Engineering, published ahead of print, doi:10.1002/mame.201700072

New Paper: Focal Adhesion Stabilization by Enhanced Integrin-cRGD Binding Affinity. D. Pallarola, I. Platzman, A. Bochen, E.A. Cavalcanti-Adam, M. Axmann, H. Kessler, B. Geiger, and J.P. Spatz (2017). BioNanoMaterials, available online. 

New Paper: Fibronectin promotes directional persistence in fibroblast migration through interactions with both its cell-binding and heparin-binding domains. D. Missirlis, T. Haraszti, H. Kessler, and J. Spatz (2017). Scientific Reports, accepted.

New Paper: Intermediate filament reorganization dynamically influences cancer cell alignment and migration. A. Holle, M. Kalafat, A. Sales Ramos, T. Seufferlein, R. Kemkemer, and J. Spatz (2017). Scientific Reports, accepted.

New Paper: Nanostructured Stealth Surfaces for Visible and Near-Infrared Light. Z. Diao, M. Kraus, R. Brunner, J. H. Dirks, J. P. Spatz (2016). Nano Letters 16, 6610-6616, doi: 10.1021/acs.nanolett.6b03308

New Paper: Substrate engagement of integrins α5β1 and αvβ3 is necessary, but not sufficient, for high directional persistence in migration on fibronectin. D. Missirlis, T. Haraszti, C. v. C. Scheele, T. Wiegand, C. Diaz, S. Neubauer, F. Rechenmacher, H. Kessler, J.P. Spatz (2016). Scientific Reports 6, 23258, doi:10.1038/srep23258

New Paper: Controlled Immobilization Strategies to Probe Short Hyaluronan-Protein Interactions  Minsky, B.B., Antoni, C.H. & Boehm, H. (2016). Scientific Reports 6, 21608, doi:10.1038/srep21608

New Paper: Synthesis of Binary Nanopatterns on Hydrogels for Initiating Cellular Responses. Guasch, J.; Diemer, J.; Riahinezhad, H.; Neubauer, S.; Kessler, H.; Spatz, J. (2016). Chemistry of Materials, accepted.

New Paper: Precise AuxPt1-x alloy nanoparticle srray of tunable composition for catalytic applications. Jahn, S., Lechner, S.J., Freichels, H., Möller, M. & Spatz, J.P. (2016). Scientific Reports, accepted.

New Paper: Primary cilia are critical for Sonic hedgehog-mediated dopaminergic neurogenesis in the embryonic midbrain Gazea, M., Tasouri, E., Bosch, V., Kabanova, A., Gojak, C., Kurtulmus, B., Novikov, O., Spatz, J., Pereira, G., Hübner, W., Brodski, C., Tucker, K.L. & Blaess, S. (2015). Developmental Biology, in press.

New Paper: Nanoscale and mechanical properties of the physiological cell-ECM microenvironment Young, J.L., Holle, A.W. & Spatz J.P. (2015). Experimental Cell Research, in press.

New Paper: In vitro cancer cell-ECM interactions inform in vivo cancer treatment  Holle, A.W., Young, J.L. & Spatz J.P. (2015). Advanced Drug Delivery Reviews, available online. doi:10.1016/j.addr.2015.10.007

New Paper: Nanopore diameters tune strain in extruded fibronectin fibers. Raoufi, M., Das, T., Schön, I., Vogel, V., Brüggemann, D. & Spatz, J. P. (2015). Nano Letters doi:10.1021/acs.nanolett.5b01356

New Paper: Segregation versus colocalization: Orthogonally functionalized binary micropatterned substrates regulate the molecular distribution in focal adhesions. Guasch, J., Conings, B., Neubauer, S., Rechenmacher, F., Ende, K., Rolli, C. G., Kappel, C., Schaufler, V., Micoulet, A., Kessler, H., Boyen, H.-G., Cavalcanti-Adam, E. A. & Spatz, J. P. (2015).  Advanced Materials doi:10.1002/adma.201500900

New Paper: A molecular mechanotransduction pathway regulates collective migration of epithelial cells. Das, T., Safferling, K., Rausch, S., Grabe, N., Böhm, H., & Spatz, J. P. (2015). Nature Cell Biology, 17, 276-287. doi:10.1038/ncb3115.

New Paper: Key factors for stable retention of fluorophores and labeled biomolecules in droplet-based microfluidics. Janiesch, J.-W., Weiss, M., Kannenberg, G., Hannabuss, J., Surrey, T., Platzman, I. & Spatz, J. P. (2015). Analytical chemistry, 87(4), 2063-7. doi:10.1021/ac504736e

New Paper: Schwab, E.H.,  Pohl, T.L.M.,  Haraszti, T., Schwaerzer, G.K., Hiepen, C., Spatz, J.P., Knaus, P. & Cavalcanti-Adam, E.A. (2015). Nanoscale control of surface immobilized BMP-2: toward a quantitative assessment of BMP-mediated signaling events. Nano Letters, available online, doi:10.1021/acs.nanolett.5b00315

New Paper: Sugihara, K., Rustom, A., & Spatz, J. P.  (2015). Freely drawn single lipid nanotube patterns. Soft Matter, 11, 2029-2035. doi:10.1039/C5SM00043B.

New Paper: Rajabi, H., Darvizeh, A., Shafiei, A., Taylor, D. & Dirks, J.-H. (2015). Numerical investigation of insect wing fracture behaviour. Journal of Biomechanics, 48(1), 89-94. doi:10.1016/j.jbiomech.2014.10.037

New Paper: Sauter, A., Mc Duffie, Y., Böhm, H., Martinez, A., Spatz, J. P., & Appel, S. (2015). Surface-Mediated Priming During In Vitro Generation of Monocyte-Derived Dendritic Cells. Scandinavian Journal of Immunology, 81(1), 56-65. doi:10.1111/sji.12246.

New Paper: Adutler-Lieber, S., Zaretsky, I., Platzman, I., Deeg, J., Friedman, N., Spatz, J. P., & Geiger, B. (2014). Engineering of synthetic cellular microenvironments: Implications for immunity. Journal of Autoimmunity, 54, 100-111. doi:10.1016/j.jaut.2014.05.003.

New Paper: Greiner, A. M., Hoffmann, P., Bruellhoff, K., Jungbauer, S., Spatz, J. P., Möller, M., Kemkemer, R., & Groll, J. (2014). Stable biochemically micro-patterned hydrogel layers control specific cell adhesion and allow long term cyclic tensile strain experiments. Macromolecular Bioscience, 14(11), 1547-1555. doi:10.1002/mabi.201400261.

New Book Chapter: Kudera, S., & Manna, L. (2014). Bottom-Up Synthesis of Nanosized Objects. In D. Berti, & G. Palazzo (Eds.), Colloidal Foundations of Nanoscience (pp. 47-80). Elsevier.

New Paper: Liu, Y., Medda, R., Liu, Z., Galior, K., Yehl, K., Spatz, J. P., Cavalcanti-Adam, E. A., & Salaita, K. (2014). Nanoparticle Tension Probes Patterned at the Nanoscale: Impact of Integrin Clustering on Force Transmission. Nano Letters, 14(10), 5539-5546. doi:10.1021/nl501912g.

New Paper: Ranzinger, J., Rustom, A., & Schwenger, V. (2014). Membrane nanotubes between peritoneal mesothelial cells: functional connectivity and crucial participation during inflammatory reactions. Frontiers in Physiology, 5: 412. doi:10.3389/fphys.2014.00412.

New Paper: Weiler, M., Quint, S., Klenk, S., & Pacholski, C. (2014). Bottom-up fabrication of nanohole arrays loaded with gold nanoparticles: extraordinary plasmonic sensors. Chemical Communications, 50(97), 15419-15422. doi:10.1039/c4cc05208k.

New Paper: Amschler, K., Erpenbeck, L., Kruss, S., Kruss, S., & Schön, M. P. (2014). Nanoscale Integrin Ligand Patterns Determine Melanoma Cell Behavior. ACS Nano, 8(9), 9113-9125. doi:10.1021/nn502690b.

New Paper: Gorniak, T., Haraszti, T., Suhonen, H., Yang, Y., Hedberg-Buenz, A., Koehn, D., Heine, R., Grunze, M., Rosenhahn, A., & Anderson, M. G. (2014). Support and challenges to the melanosomal casing model based on nanoscale distribution of metals within iris melanosomes detected by X-ray fluorescence analysis. Pigment Cell & Melanoma Research, 27, 831-834. doi:10.1111/pcmr.12278.

New Paper: Masson, F., Breault-Turcot, J., Faid, R., Poirier-Richard, H.-P., Yockell-Lelièvre, H., Lussier, F., & Spatz, J. P. (2014). Plasmonic nanopipette biosensor. Analytical Chemistry, 86(18), 8998-9005. doi:10.1021/ac501473c.

New Paper: Ranzinger, J., Rustom, A., Heide, D., Morath, C., Schemmer, P., Nawroth, P.P., Zeier, M. & Schwenger, V. (2014). The receptor for advanced glycation end-products (RAGE) plays a key role in the formation of nanotubes (NTs) between peritoneal mesothelial cells and in murine kidneys. Cell and Tissue Research, 357(3), 667-679. doi: 10.1007/s00441-014-1904-y

New Paper: Balderas-Valadez, R., Weiler, M., Agarwal, V., & Pacholski, C. (2014). Optical characterization of porous silicon monolayers decorated with hydrogel microspheres. Nanoscale Research Letters, 9: 425. doi:10.1186/1556-276X-9-425.

New Paper: Brüggemann, D., Frohnmayer, J. P., & Spatz, J. P. (2014). Model systems for studying cell adhesion and biomimetic actin networks. Beilstein Journal of Nanotechnology, 5, 1193-1202. doi:10.3762/bjnano.5.131.

New Paper: Hirschfeld-Warneken, V. C., & Spatz, J. P. (2014). Genauere Krebsdiagnose durch Fraktalanalyse. Spektrum der Wissenschaft, 9, 14-16.

New Paper: Nisenholz, N., Rajendran, K., Dang, Q., Chen, H., Kemkemer, R., Ramaswamy, K., & Zemel, A. (2014). Active mechanics and dynamics of cell spreading on elastic substrates. Soft Matter, 10, 7234-7246. doi:10.1039/c4sm00780h.

New Paper: Scheeler, S., Lehr, D., Kley, E.-B., & Pacholski, C. (2014). Top-Up Fabrication of Gold Nanorings. Chemistry – An Asian Journal, 9, 2072-2076. doi:0.1002/asia.201402182.

New Paper: Stanglmair, C., Scheeler, S., & Pacholski, C. (2014). Seeding Growth Approach to Gold Nanoparticles with Diameters Ranging from 10 to 80 Nanometers in Organic Solvent. European Journal of Inorganic Chemistry, 23, 3633-3637. doi:10.1002/ejic.201402467.

New Paper: Dirks, J.-H. (2014). Physical principles of fluid-mediated insect attachment - Shouldn’t insects slip? Beilstein Journal of Nanotechnology, 5, 1160-1166. doi:10.3762/bjnano.5.127.

New Paper: Lee-Thedieck, C., & Spatz, J. P. (2014). Biophysical regulation of hematopoietic stem cells. Biomaterials Science, 2, 1548-1561. doi: 10.1039/C4BM00128A.

New Paper: Mills, K., Kemkemer, R., Rudraraju, S., & Garikipati, K. (2014). Elastic Free Energy Drives the Shape of Prevascular Solid Tumors. PLoS One, 9(7): e103245. doi: 10.1371/journal.pone.0103245.

New Paper: Quint, S., & Pacholski, C. (2014). Getting real: influence of structural disorder on the performance of plasmonic hole array sensors fabricated by a bottom-up approach. Journal of Materials Chemistry C: Materials for Optical and Electronic Devices, 2, 7632-7638. doi:10.1039/C4TC01244E.

New Paper: Schenk, F. C., Böhm, H., Spatz, J. P., & Wegner, S. V. (2014). Dual-Functionalized Nanostructured Biointerfaces by Click Chemistry. Langmuir, 30(23), 6897-6905. doi:10.1021/la500766t.

New Book Chapter: Brüggemann, D., Wolfrum, B., & de Silva, J. P. (2014). Fabrication, Properties and Applications of Gold Nanopillars. In B. Bhushan (Ed.), Handbook of Nanomaterials Properties (pp. 317-354). Berlin Heidelberg: Springer.

New Paper: Mateescu, M., Nuss, I., Southan, A., Messenger, H., Wegner, S., Kupka, J., Bach, M., Tovar, G. E., Böhm, H., & Laschat, S. (2014). Synthesis of Pyridine Acrylates and Acrylamides and Their Corresponding Pyridinium Ions as Versatile Cross-Linkers for Tunable Hydrogels. Synthesis, 46(9), 1243-1253. doi:10.1055/s-0033-1338614.

New Paper: Spatz, J. P., & Schaal, S. (2014). Intelligent Systems: Bits and Bots. Nature - Supplements, 5 0 9 ( 7 5 0 2 ) . R e t r i e v e d f r o m h t t p : / / w w w . n a t u r e . c o m / n a t u r e / s u p p l e m e n t s / c o l l e c t i o n s / n p g p u b l i c a t i o n s / p l a n c k / .

New Paper: Missirlis, D. (2014). The Effect of Substrate Elasticity and Actomyosin Contractility on Different Forms of Endocytosis. PLoS ONE, 9(5): e96548. doi:10.1371/journal.pone.0096548.

New Paper: Sun, J. G., Gräter, S., Tang, J., Huang, J., Liu, P., Lai, Y., Majer, G., Spatz, J. P., & Ding, J. (2014). Preparation of stable micropatterns of gold on cell-adhesion-resistant hydrogels assisted by a hetero-bifunctional macromonomer linker. Science China Chemistry, 57, 645-653. doi:10.1007/s11426-013-5057-8.

New Paper: Vijayakumar, A., Eigenthaler, U., Keskinbora, K., Sridharan, G. M., Pramitha, V., Hirscher, M., Spatz, J. P., & Bhattacharya, S. (2014). Optimizing the fabrication of diffractive optical elements using a focused ion beam system. Proceedings of SPIE, 9130: 91300X. doi:10.1117/12.2051925.

New Paper: Corall, S., Haraszti, T., Bartoschik, T., Spatz, J. P., Ludwig, T., & Cavalcanti-Adam, E. A. (2014). α5β1-integrin and MT1-MMP promote tumor cell migration in 2D but not in 3D fibronectin microenvironments. Computational Mechanics, 53(3), 499-510. 

New Paper: Gorniak, T., Haraszti, T., Garamus, V. M., Buck, A. R., Senkbeil, T., Priebe, M., Hedberg-Buenz, A., Koehn, D., Salditt, T., Grunze, M., Anderson, M. G., & Rosenhahn, A. (2014). Nano-Scale Morphology of Melanosomes Revealed by Small-Angle X-Ray Scattering. PLoS One, 9(3): e90884. doi:10.1371/journal.pone.0090884.

New Paper: Majer, G., & Melchior, J. P. (2014). Characterization of the fluorescence correlation spectroscopy (FCS) standard Rhodamine 6G and calibration of its diffusion coefficient in aqueous solutions. The Journal of Chemical Physics, 140: 094201. doi:10.1063/1.4867096.

New Paper: Shimizu, Y., Böhm, H., Yamaguchi, K., Spatz, J. P., & Nakanishi, J. (2014). A Photoactivatable Nanopatterned Substrate for Analyzing Collective Cell Migration with Precisely Tuned Cell-E x t r a c e l l u l a r M a t r i x L i g a n d I n t e r a c t i o n s . P L o S O n e , 9 ( 3 ) : e 9 1 8 7 5 . d o i : 1 0 . 1 3 7 1 / j o u r n a l . p o n e . 0 0 9 1 8 7 5 .

New Paper: Glenske, K., Wagner, A.-S., Hanke, T., Cavalcanti-Adam, E. A., Heinemann, S., Heinemann, C., Kruppke, B., Arnhold, S., Moritz, A., Schwab, E., Worch, H., & Wenisch, S. (2014). Bioactivity of xerogels as modulators of osteoclastogenesis mediated by connexin 43. Biomaterials, 35(5), 1487-1495. doi:10.1016/j.biomaterials.2013.11.002.

New Paper: Medda, R., Helth, A., Herre, P., Pohl, D., Rellinghaus, B., Perschmann, N., Neubauer, S., Kessler, H., Oswald, S., Eckert, J., Spatz, J. P., Gebert, A., & Cavalcanti-Adam, E. A. (2014). Investigation of early cell–surface interactions of human mesenchymal stem cells on nanopatterned β-type titanium–niobium alloy surfaces. Interface Focus, 4(1), 20130046. doi:10.1098/rsfs.2013.0046.

New Book Chapter: Platzman, I., Gadomska, K. M., Janiesch, J.-W., Louban, I., Cavalcanti-Adam, E. A., & Spatz, J. P. (2014). Soft/Elastic Nanopatterned Biointerfaces in the Service of Cell Biology. In M. Piel, & M. Théry (Eds.), Micropatterning in Cell Biology, Part A (pp. 237-260). Academic Press.

New Paper: Pallarola, D., Bochen, A., Böhm, H., Rechenmacher, F., Sobahi, T., Spatz, J. P., & Kessler, H. (2014). Interface Immobilization Chemistry of cRGD-based Peptides Regulates Integrin Mediated Cell Adhesion. Advanced Functional Materials, 24(7), 943-956. doi:10.1002/adfm.201302411.

New Paper: Liu, Y., Medda, R., Cavalcanti-Adam, E. A. & Salaita, K. (2014). Investigating Focal Adhesion Mechanics using Nanopatterned Molecular Tension Fluorescence Microscopy (MTFM). Biophysical Journal, 106(2), 424A.

New Paper: Missirlis, D., & Spatz, J. P. (2014). Combined Effects of PEG Hydrogel Elasticity and Cell-Adhesive Coating on Fibroblast Adhesion and Persistent Migration. Biomacromolecules, 15(1), 195-205. doi:10.1021/bm4014827.

New Paper: Raic, A., Rödling, L., Kalbacher, H., & Lee-Thedieck, C. (2014). Biomimetic macroporous PEG hydrogels as 3D scaffolds for the multiplication of human hematopoietic stem and progenitor cells. Biomaterials, 35, 929-940. doi:10.1016/j.biomaterials.2013.10.038.

New Paper: Polarizing cytoskeletal tension to induce leader cell formation during collective cell migration.

Rausch, S., Das, T., Soiné, J. R. D., Hofmann, T. W., Böhm, C., Schwarz, U., et al. (2013). Polarizing cytoskeletal tension to induce leader cell formation during collective cell migration. Biointerphases, 8:. doi:10.1186/1559-4106-8-32. [mehr]

New Paper: Marker-Free Phenotyping of Tumor Cells by Fractal Analysis of Reflection Interference Contrast Microscopy Images 

Klein, K., Maier, T., Hirschfeld-Warneken, V. C., & Spatz, J. P. (2013). Marker-Free Phenotyping of Tumor Cells by Fractal Analysis of Reflection Interference Contrast Microscopy Images. Nano Letters, 13(11), 5474-5479. doi:10.1021/nl4030402.


New Paper: Photonic Crystal Sensors Based on Porous Silicon

Pacholski, C. (2013). Photonic Crystal Sensors Based on Porous Silicon. Sensors, 13, 4694-4713. doi:10.3390/s130404694.


New Paper: Tunneling nanotubes, an emerging intercellular communication route in development

Gerdes, H.-H., Rustom, A., & Wang, X. (2013). Tunneling nanotubes, an emerging intercellular communication route in development. Mechanisms of Development, 130, 381-387. doi:10.1016/j.mod.2012.11.006. [mehr]

New Paper: α5β1-integrin and MT1-MMP promote tumor cell migration in 2D but not in 3D fibronectin microenvironments.

E.A. Cavalcanti-Adam, T. Ludwig, S. Corall, T. Bartoschik, T. Haraszti, and J.P. Spatz. In: Computational Mechanics 2013, accepted

New Paper: Soft/Elastic Nano-Patterned Biointerfaces in the Service of Cell Biology.

Platzman, I.; Gadomska, K. M.; Janiesch, J.-W.; Louban, I.; Cavalcanti-Adam, E. A.; Spatz, J. P. In: Methods in Cell Biology (Eds.: M. Piel & M. Théry) Micropatterning in Cell Biology, V119-Ch12, 2013.

New Paper: Diffusion and Interaction in PEG-DA Hydrogels

Hagel, V., Haraszti, T.; Böhm, H. In: Biointerphases 2013, accepted

New Paper: The role of integrin-linked kinase in the molecular architecture of focal adhesions.

Elad, N.; Volberg, T.; Patla, I.; Hirschfeld-Warneken, V. C.; Grashoff, C.; Spatz, J. P.; Fässler, R.; Geiger, B.; Medalia, O. In: Journal of Cell Science 2013, 126, 4099-4107. doi: 10.1242/ jcs.120295 [mehr]

New Paper: Artificial Antigen-Presenting Interfaces in the Service of Immunology.

Platzman, I.; Janiesch J.-W.; Matić , J.; Spatz, J. P. In: Israel Journal of Chemistry, 53, 655–669 (2013). DOI: 10.1002/ijch.201300060 [mehr]

New Paper: Interface Immobilization Chemistry of cRGD-based Peptides Regulates Integrin Mediated Cell Adhesion.

Pallarola, D.; Bochen, A.; Böhm, H.; Rechenmacher, F.; Spatz, J. P.; Kessler, H. In: Advanced Functional Materials 2013, accepted.

New Paper: Fine tuning and efficient T cell activation with stimulatory aCD3 nano-arrays I.

Matic, J.; Deeg, J.; Scheffold, A.; Goldstein, I.; Spatz, J. P. In: Nano Letters 2013, accepted.

New Paper: Adhesion Maturation of Neutrophils on Nanoscopically Presented Platelet Glycoprotein Ibα.

Kruss, S.; Erpenbeck, L.; Amschler, K.; Mundinger, T. A.; Böhm, H.; Helms, H.-J.; Friede, T.; Andrews, R.; Schön, M.; Spatz, J. P. In: ACS Nano 2013, accpeted.

New Paper: Marker-free phenotyping of tumor cells by fractal analysis of RICM images. 

Klein, K.; Maier, T.; Hirschfeld-Warneken, V. C.; Spatz, J. P. In: Nano Letters 2013, accepted.

New Paper: Cell membrane topology analysis by RICM enables marker-free adhesion strength quantification.

Klein, K.; Hirschfeld-Warneken, V. C.; Spatz, J. P.; Rommel, C. E. In: Biointerphases 2013, accepted.

New Paper: Cyclic tensile strain controls cell shape and directs actin stress fiber formation and focal adhesion alignment in spreading cells. 

Greiner, A. M.; Chen, H.; Spatz, J. P.; Kemkemer, R. In: PLoS ONE 2013, accepted.

New Paper: T cell activation is determined by the number of presented antigens.

Deeg, J.; Axmann, M.; Matic, J.; Liapis, A.; Depoil, D.; Curado, S.; Dustin, M. L.; Spatz, J. P. In: Nano Letters 2013, accepted.

New Paper: Gold nanoparticle-decorated glass microspheres.

Gadomska, K. M., S. J. Lechner and J. P. Spatz. In: Particle & Particle Systems Characterization (2013) accepted.

New Paper: Real-time monitoring of electrochemical controlled protein adsorption by a plasmonic nanowire based sensor.

Pallarola, D., M. Schneckenburger, C. Pacholski and J. P. Spatz. In: ChemComm (2013) in press.

New Paper: Selective modulation of cell response on engineered fractal silicon substrates.

Gentile, F., Medda, R., Cheng, L., Battista, E., Scopelliti, P. E., Milani, P., Cavalcanti-Adam, E. A., & Decuzzi, P. In: Scientific Reports (2013), 3: 1461. doi:10.1038/srep01461.


New Paper: Adaptive optics enables three-dimensional single particle tracking at the sub-millisecond scale.

Juette, M. F., Rivera-Molina, F. E., Toomre, D. K., & Bewersdorf, J. In: Applied Physics Letters (2013), 102(17), 173702-1-173702-4. doi:dx.doi.org/10.1063/1.4803538.


New Paper: Spatial organization and mechanical properties of the pericellular matrix on chondrocytes.

McLane, L. T., Chang, P., Granqvist, A., Böhm, H., Kramer, A., Scrimgeour, J., & Curtis, J. E. In: Biophysical Journal (2013), 104, 986-996. doi:10.1016/j.bpj.2013.01.028.


New Paper: The non-peptidic part determines the internalization mechanism and intracellular trafficking of peptide amphiphiles.

Missirlis, D., Teesalu, T., Black, M., & Tirrell, M. In: PLoS One (2013), 8(1), e54611. doi:10.1371/journal.pone.0054611.


New Paper: Regulation of Hematopoietic Stem Cell Behavior by the Nanostructured Presentation of Extracellular Matrix Components.

Muth, C. A., Steinl, C., Klein, G., & Lee-Thedieck, C. In: PLoS One (2013), 8(2), e54778. doi:10.1371/journal.pone.0054778.


New Paper: BCAT1 promotes cell proliferation through amino acid catabolism in gliomas carrying wild-type IDH1.

Tönjes, M., Barbus, S., Park, Y. J., Wang, W., Schlotter, M., Lindroth, A. M., Pleier, S. V., Bai, A. H., Karra, D., Piro, R. M., Felsberg, J., Addington, A., Lemke, D., Weibrecht, I., Hovestadt, V., Rolli, C. G., Campos, B., Turcan, S., Sturm, D., Witt, H., Chan, T. A., Herold-Mende, C., Kemkemer, R., König, R., Schmidt, K., Hull, W.-E., Pfister, S. M., Jugold, M., Hutson, S., Plass, C., Okun, J. G., Reifenberger, G., Lichter, P., & Radlwimmer, B. In: Nature Medicine (2013), 19, 901-908. doi:10.1038/nm.3217.


Welcome Dr. Masson!

July 3rd 2013 - We welcome Dr. Jean-Francois Masson, a new guest researcher in our group, who will stay with us for six months over the next year. Dr. Masson is Associate Professor of bioanalytical chemistry at the Universite de Montreal, Canada, and an awardee of the prestigious Humboldt Research Fellowship for Experienced Researchers. [mehr]

New Paper: Hydrogel micropillars with integrin selective peptidomimetic functionalized nanopatterned tops: a new tool for the measurement of cell traction forces transmitted through αvβ3 or α5β1 integrins.

Rahmouni, S., A. Lindner, F. Rechenmacher, S. Neubauer, T.R.A. Sobahi, H. Kessler, E.A. Cavalcanti-Adam, and J.P. Spatz. In: Advanced Materials (2013) accepted.

New Paper: Towards controlling the formation, degradation behavior and properties of hydrogels synthesized by Aza-Michael reactions. 

Southan, A., M. Mateescu, V. Hagel, M. Bach, C. Schuh, C. Kleinhans, P.J. Kluger, S. Tussetschläger, I. Nuss, T. Haraszti, S.V. Wegner, J.P. Spatz, H. Böhm, S. Laschat, and G.E.M. Tovar. In: Macromolecular Chemistry and Physics (2013) accepted

New Paper: Desmosine-Inspired Cross-Linkers for Hyaluronan Hydrogels. 

Hagel, V., M. Mateescu, A. Southan, S.V. Wegner, I. Nuss, T. Haraszti, C. Kleinhans, C. Schuh, J.P. Spatz, P.J. Kluger, M. Bach, S. Tussetschläger, G.E.M. Tovar, S. Laschat, and H. Böhm. In: Scientific Reports 3 (2013). DOI: 10.1038/srep02043 (2013).


New Paper: The role of integrin-linked kinase in the molecular architecture of focal adhesions. 

Medalia, O., N. Elad, I. Patla, T. Volberg, V.C. Hirschfeld-Warneken, J.P. Spatz, C. Grashoff, R. Fässler, and B. Geiger. In: Journal of Cell Science (2013) accepted.

New Paper: Surface Properties of Nanostructured Bio-Active Interfaces: Impacts of Surface Stiffness and Topography on Cell-Surface Interactions

Platzman, I., C. Muth, C. Lee-Thedieck, D. Pallarola, R. Atanasova, I. Louban, E. Altrock, and J.P. Spatz. In: RSC Advances (2013) available online. DOI: 10.1039/C3RA41579A (2013). [mehr]

New Paper: A Molecular Toolkit for the Functionalization of Titanium-Based Biomaterials That Selectively Control Integrin-Mediated Cell Adhesion. 

Rechenmacher, F., S. Neubauer, C. Mas-Moruno, P.M. Dorfner, J. Polleux, J. Guasch, B. Conings, H.-G. Boyen, A. Bochen, T.R. Sobahi, R. Burgkart, J.P. Spatz, R. Fässler, and H. Kessler. In: Chemistry – A European Journal (2013) available online. doi: 10.1002/chem.201301478 [mehr]

New Paper: Effective polyethylene glycol passivation for the inhibition of surface interactions of peripheral blood mononuclear cells and platelets

Sauter, A., G. Richter, A. Micoulet, A. Martinez, J.P. Spatz, and S. Appel. In: Biointerphases (2013) accepted.

Welcome Dr. Banerjee!

May 22nd 2013 - We welcome Dr. Indranil Banerjee, a new guest researcher in our group, who will stay with us over the next two months. Dr. Banerjee is Assistant Professor at the Department of Biotechnology and Medical Engineering, National Institute of Technology Rourkela, India.

New Paper: Biselectivity of IsoDGR Peptides for Fibronectin Binding Integrin Subtypes α5β1 and αvβ6: Conformational Control through Flanking Amino Acids.

Bochen, A.; Marelli, U. K.; Otto, E.; Pallarola, D.; Mas-Moruno, C.; Di Leva, F. S.; Boehm, H.; Spatz, J. P.; Novellino, E.; Kessler, H.; Marinelli, L., In: Journal of Medicinal Chemistry 2013, 56, 1509-1519. DOI: 10.1021 [mehr]

New Paper: Cobalt(III) as a Stable and Inert Mediator Ion between NTA and His6-tagged Proteins.

Wegner, S. V.; Spatz, J. P., In: Angewandte Chemie Int. Ed. 2013, accepted. DOI: 10.1002/anie.201210317


New Paper: The Effect of Molar Mass and Degree of Hydroxyethylation on the Controlled Shielding and Deshielding of Hydroxyethyl Starch-Coated Polyplexes. 

Noga, M.; Erdinger, D.; Kläger, R.; Wegner, S. V.; Spatz, J. P.; Wagner, E.; Winter, G.; Besheer, A., In: Biomaterials 2013, 34, 2530-2538. DOI: 10.1016/j.biomaterials.2012.12.025


New Paper: Tunable Substrates Unveil Chemical Complementation of a Genetic Cell Migration Defect. 

Hellmann, J. K.; Perschmann, N.; Spatz, J. P.; Frischknecht, F., In: Advanced Healthcare Materials 2013, available online. DOI: 10.1002/adhm.201200426


New Paper: Contact Line Motion on Nanorough Surfaces: a Thermally Activated Process.

Ramiasa, M.; Ralston, J.; Fetzer, R.; Sedev, R.; Fopp-Spori, D. M.; Morhard, C.; Pacholski, C.; Spatz, J. P., In: Journal of the American Chemical Society 2013, available online. DOI: 10.1021/ja3104846


Training Immune Cells To Combat Disease

5. März 2013

C&EN press release


Synthetic Biology Approach to Adhesion-Mediated Environmental Sensing

31. Januar 2012

ERC Advanced Grant 2011 for a Collaborative Project between the Max Planck Society and the Weizmann Institute of Science. Professors Joachim Spatz (Max Planck Institute for Intelligent Systems, Germany) and Benjamin Geiger (Weizmann Institute of Science, Israel) received funding of up to 3.5 Million Euros for their project 'Synthetic Biology Approach to Adhesion-Mediated Environmental Sensing' [mehr]


We present a micro-fabricated chip equipped with channel structures of different sizes designed to study cell migration on a single-cell level in real-time. With pancreatic cancer cells... [mehr]