Nanoelectronics for Cellular Interfaces (Diego Pallarola)
Biologically inspired materials that mimic the cell´s natural surrounding and have the ability to transduce cellular signaling activities are ideal for gaining insights into the chemical and physical cues regulating these events. Our approach builds upon real-time monitoring of cellular processes by simultaneous optical microscopy and electrochemical techniques on nanostructured surfaces with a defined spatial arrangement of adhesion sites for cells. The advantages of this approach can be summed up as follows: the chance to test cellular responses under specifically engineered environments in a highly sensitive, label-free, instantaneous and non-destructive manner.
The specific knowledge obtained from this interdisciplinary approach creates a better understanding of cell adhesion dynamics and lays the foundation for further developments in biosensing technologies.