In this talk, I'd like to discuss the intertwining importance and connections of three principles of data science in the title. They will be demonstrated in the context of two collaborative projects in neuroscience and genomics, respectively. The first project in neuroscience
uses transfer learning to integrate fitted convolutional neural networks (CNNs) on ImageNet with regression methods to provide predictive and stable characterizations of neurons from the challenging primary visual cortex V4. The second project proposes iterative random forests (iRF) as a stablized RF to seek predictable and interpretable high-order interactions among biomolecules.
Algorithms for survival: a decision-theoretic perspective on adaptive action under threat
Under acute threat, biological agents need to choose adaptive actions to survive. In my talk, I will provide a decision-theoretic view on this problem and ask, what are potential computational algorithms for this choice, and how are they implemented in neural circuits. Rational design principles and non-human animal data tentatively suggest a specific architecture that heavily relies on tailored algorithms for specific threat scenarios. Virtual reality computer games provide an opportunity to translate non-human animal tasks to humans and investigate these algorithms across species. I will discuss the specific challenges for empirical inference on underlying neural circuits given such architecture.
Biography: Bin Yu is Chancellor’s Professor in the Departments of Statistics and of Electrical Engineering & Computer Sciences at the University of California at Berkeley. Her current research interests focus on statistics and machine learning theory, methodologies and algorithms for solving high-dimensional data problems. Her group is engaged in interdisciplinary research with scientists from genomics, neuroscience, and precision medicine. She obtained her B.S. degree in Mathematics from Peking University in 1984, her M.A. and Ph.D. degrees in Statistics from the University of California at Berkeley in 1987 and 1990, respectively. She is Member of the U.S. National Academy of Sciences and Fellow of the American Academy of Arts and Sciences. She was a Guggenheim Fellow in 2006, and the Tukey Memorial Lecturer of the Bernoulli Society in 2012. She was President of IMS (Institute of Mathematical Statistics) in 2013-2014 and the Rietz Lecturer of IMS in 2016.