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2019


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A semi-analytical model for dynamic analysis of non-uniform plates

Gozum, M. M., Serhat, G., Basdogan, I.

Applied Mathematical Modelling, 76, pages: 883–899, December 2019 (article)

Abstract
Dynamic properties of the plate structures can be enhanced by introducing discontinuities of different kinds such as using surface-bonded discrete patches or spatially varying the stiffness and mass properties of the plate. Fast and reliable design of such complex structures requires efficient and accurate modeling tools. In this study, a novel semi-analytical model is developed for the dynamic analysis of plates having discrete and/or continuous non-uniformities. Two-dimensional Heaviside unit step functions are utilized to represent the discontinuities. Different from existing numerical methods based on Heaviside functions, a numerical technique is proposed for modeling the discontinuities that are not necessarily aligned with the plate axes. The governing equations are derived using Hamilton's principle and Rayleigh–Ritz method is used for determining the modal variables. The surface-bonded patches are used to demonstrate discrete non-uniformities where variable-stiffness laminates are selected to represent continuous non-uniform structures. Natural frequencies and mode shapes obtained using the proposed method are validated with finite element analyses and the existing results from the literature. The results show that the developed model performs accurately and efficiently.

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DOI [BibTex]

2019


DOI [BibTex]


A Robotic Framework to Facilitate Sensory Experiences for Children with Autism Spectrum Disorder: A Preliminary Study
A Robotic Framework to Facilitate Sensory Experiences for Children with Autism Spectrum Disorder: A Preliminary Study

Javed, H., Burns, R., Jeong, M., Howard, A. M., Park, C. H.

ACM Transactions on Human-Robot Interaction (THRI), 9(1), December 2019 (article)

Abstract
The diagnosis of Autism Spectrum Disorder (ASD) in children is commonly accompanied by a diagnosis of sensory processing disorders. Abnormalities are usually reported in multiple sensory processing domains, showing a higher prevalence of unusual responses, particularly to tactile, auditory, and visual stimuli. This article discusses a novel robot-based framework designed to target sensory difficulties faced by children with ASD in a controlled setting. The setup consists of a number of sensory stations, together with two different robotic agents that navigate the stations and interact with the stimuli. These stimuli are designed to resemble real-world scenarios that form a common part of one’s everyday experiences. Given the strong interest of children with ASD in technology in general and robots in particular, we attempt to utilize our robotic platform to demonstrate socially acceptable responses to the stimuli in an interactive, pedagogical setting that encourages the child’s social, motor, and vocal skills, while providing a diverse sensory experience. A preliminary user study was conducted to evaluate the efficacy of the proposed framework, with a total of 18 participants (5 with ASD and 13 typically developing) between the ages of 4 and 12 years. We derive a measure of social engagement, based on which we evaluate the effectiveness of the robots and sensory stations to identify key design features that can improve social engagement in children.

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DOI [BibTex]

DOI [BibTex]


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Multi-objective optimization of composite plates using lamination parameters

Serhat, G., Basdogan, I.

Materials & Design, 180(107904), October 2019 (article)

Abstract
Laminated composite plates are extensively used in various industries due to their high stiffness-to-weight ratio and directional properties that allow optimization of the stiffness characteristics for specific applications. In multi-objective optimization problems, optimal designs for individual performance metrics may be conflicting, necessitating knowledge on the design requirements for different metrics and potential trade-offs. In this paper, a multi-objective design methodology for laminated composite plates with dynamic and load-carrying requirements is presented. Lamination parameters are used to characterize laminate stiffness matrices in a compact form resulting in a convex design space. Single and multi-objective optimization studies are carried out to determine the optimal stiffness properties. For improving the dynamic performance, maximization of the fundamental frequency metric is aimed. For enhancing the load-carrying capability, buckling load and equivalent stiffness metrics are maximized. Conforming and conflicting behavior of multiple objective functions for different plate geometries, boundary conditions and load cases are presented by determining Pareto-optimal solutions. The results provide a valuable insight for multi-objective optimization of laminated composite plates and show that presented methodology can be used in the design of such structures for improving the dynamic and load-carrying performance.

hi

DOI [BibTex]

DOI [BibTex]


Series Elastic Behavior of Biarticular Muscle-Tendon Structure in a Robotic Leg
Series Elastic Behavior of Biarticular Muscle-Tendon Structure in a Robotic Leg

Ruppert, F., Badri-Spröwitz, A.

Frontiers in Neurorobotics, 64, pages: 13, 13, August 2019 (article)

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Frontiers YouTube link (url) DOI [BibTex]

Frontiers YouTube link (url) DOI [BibTex]


Beyond Basins of Attraction: Quantifying Robustness of Natural Dynamics
Beyond Basins of Attraction: Quantifying Robustness of Natural Dynamics

Steve Heim, , Spröwitz, A.

IEEE Transactions on Robotics (T-RO) , 35(4), pages: 939-952, August 2019 (article)

Abstract
Properly designing a system to exhibit favorable natural dynamics can greatly simplify designing or learning the control policy. However, it is still unclear what constitutes favorable natural dynamics and how to quantify its effect. Most studies of simple walking and running models have focused on the basins of attraction of passive limit cycles and the notion of self-stability. We instead emphasize the importance of stepping beyond basins of attraction. In this paper, we show an approach based on viability theory to quantify robust sets in state-action space. These sets are valid for the family of all robust control policies, which allows us to quantify the robustness inherent to the natural dynamics before designing the control policy or specifying a control objective. We illustrate our formulation using spring-mass models, simple low-dimensional models of running systems. We then show an example application by optimizing robustness of a simulated planar monoped, using a gradient-free optimization scheme. Both case studies result in a nonlinear effective stiffness providing more robustness.

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arXiv preprint arXiv:1806.08081 T-RO link (url) DOI Project Page [BibTex]

arXiv preprint arXiv:1806.08081 T-RO link (url) DOI Project Page [BibTex]


Learning Variable Impedance Control for Contact Sensitive Tasks
Learning Variable Impedance Control for Contact Sensitive Tasks

Bogdanovic, M., Khadiv, M., Righetti, L.

arXiv preprint, arXiv:1907.07500, July 2019 (article)

Abstract
Reinforcement learning algorithms have shown great success in solving different problems ranging from playing video games to robotics. However, they struggle to solve delicate robotic problems, especially those involving contact interactions. Though in principle a policy outputting joint torques should be able to learn these tasks, in practice we see that they have difficulty to robustly solve the problem without any structure in the action space. In this paper, we investigate how the choice of action space can give robust performance in presence of contact uncertainties. We propose to learn a policy that outputs impedance and desired position in joint space as a function of system states without imposing any other structure to the problem. We compare the performance of this approach to torque and position control policies under different contact uncertainties. Extensive simulation results on two different systems, a hopper (floating-base) with intermittent contacts and a manipulator (fixed-base) wiping a table, show that our proposed approach outperforms policies outputting torque or position in terms of both learning rate and robustness to environment uncertainty.

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[BibTex]


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Lamination parameter interpolation method for design of manufacturable variable-stiffness composite panels

Serhat, G., Basdogan, I.

AIAA Journal, 57(7):3052–3065, July 2019 (article)

Abstract
Variable-stiffness laminates have lately drawn attention because they offer potential for additional structural performance improvements. In the optimization studies, laminate stiffness properties can be described efficiently by using lamination parameters, which is a well-established formulation for constant-stiffness laminates. However, ensuring manufacturability in the design of variable-stiffness laminates with lamination parameters is difficult. In this paper, a novel method for the design of variable-stiffness composite panels using lamination parameters is proposed. The method constrains the design space by controlling the magnitude and direction of change for the lamination parameters, and subsequently leads to a smooth change in the fiber angles. The method is used to maximize the fundamental frequencies of several panels as example cases. The solutions are calculated for various panel geometries and boundary conditions using the developed finite element analysis software. After finding optimal lamination parameter distributions, corresponding discrete fiber angles and fiber paths are retrieved, and the minimum radii of curvature are calculated. The results demonstrate that the proposed design method provides manufacturable smooth fiber paths while using the compact stiffness formulation feature of lamination parameters.

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DOI [BibTex]


Implementation of a 6-{DOF} Parallel Continuum Manipulator for Delivering Fingertip Tactile Cues
Implementation of a 6-DOF Parallel Continuum Manipulator for Delivering Fingertip Tactile Cues

Young, E. M., Kuchenbecker, K. J.

IEEE Transactions on Haptics, 12(3):295-306, June 2019 (article)

Abstract
Existing fingertip haptic devices can deliver different subsets of tactile cues in a compact package, but we have not yet seen a wearable six-degree-of-freedom (6-DOF) display. This paper presents the Fuppeteer (short for Fingertip Puppeteer), a device that is capable of controlling the position and orientation of a flat platform, such that any combination of normal and shear force can be delivered at any location on any human fingertip. We build on our previous work of designing a parallel continuum manipulator for fingertip haptics by presenting a motorized version in which six flexible Nitinol wires are actuated via independent roller mechanisms and proportional-derivative controllers. We evaluate the settling time and end-effector vibrations observed during system responses to step inputs. After creating a six-dimensional lookup table and adjusting simulated inputs using measured Jacobians, we show that the device can make contact with all parts of the fingertip with a mean error of 1.42 mm. Finally, we present results from a human-subject study. A total of 24 users discerned 9 evenly distributed contact locations with an average accuracy of 80.5%. Translational and rotational shear cues were identified reasonably well near the center of the fingertip and more poorly around the edges.

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DOI [BibTex]


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The Perception of Ultrasonic Square Reductions of Friction With Variable Sharpness and Duration

Gueorguiev, D., Vezzoli, E., Sednaoui, T., Grisoni, L., Lemaire-Semail, B.

IEEE Transactions on Haptics, 12(2):179-188, January 2019 (article)

Abstract
The human perception of square ultrasonic modulation of the finger-surface friction was investigated during active tactile exploration by using short frictional cues of varying duration and sharpness. In a first experiment, we asked participants to discriminate the transition time and duration of short square ultrasonic reductions of friction. They proved very sensitive to discriminate millisecond differences in these two parameters with the average psychophysical thresholds being 2.3–2.4 ms for both parameters. A second experiment focused on the perception of square friction reductions with variable transition times and durations. We found that for durations of the stimulation larger than 90 ms, participants often perceived three or four edges when only two stimulations were presented while they consistently felt two edges for signals shorter than 50 ms. A subsequent analysis of the contact forces induced by these ultrasonic stimulations during slow and fast active exploration showed that two identical consecutive ultrasonic pulses can induce significantly different frictional dynamics especially during fast motion of the finger. These results confirm the human sensitivity to transient frictional cues and suggest that the human perception of square reductions of friction can depend on their sharpness and duration as well as on the speed of exploration.

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DOI [BibTex]

DOI [BibTex]


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How Does It Feel to Clap Hands with a Robot?

Fitter, N. T., Kuchenbecker, K. J.

International Journal of Social Robotics, 2019 (article) Accepted

Abstract
Future robots may need lighthearted physical interaction capabilities to connect with people in meaningful ways. To begin exploring how users perceive playful human–robot hand-to-hand interaction, we conducted a study with 20 participants. Each user played simple hand-clapping games with the Rethink Robotics Baxter Research Robot during a 1-h-long session involving 24 randomly ordered conditions that varied in facial reactivity, physical reactivity, arm stiffness, and clapping tempo. Survey data and experiment recordings demonstrate that this interaction is viable: all users successfully completed the experiment and mentioned enjoying at least one game without prompting. Hand-clapping tempo was highly salient to users, and human-like robot errors were more widely accepted than mechanical errors. Furthermore, perceptions of Baxter varied in the following statistically significant ways: facial reactivity increased the robot’s perceived pleasantness and energeticness; physical reactivity decreased pleasantness, energeticness, and dominance; higher arm stiffness increased safety and decreased dominance; and faster tempo increased energeticness and increased dominance. These findings can motivate and guide roboticists who want to design social–physical human–robot interactions.

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[BibTex]

[BibTex]


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X-ray Optics Fabrication Using Unorthodox Approaches

Sanli, U., Baluktsian, M., Ceylan, H., Sitti, M., Weigand, M., Schütz, G., Keskinbora, K.

Bulletin of the American Physical Society, APS, 2019 (article)

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[BibTex]

[BibTex]


Microrobotics and Microorganisms: Biohybrid Autonomous Cellular Robots
Microrobotics and Microorganisms: Biohybrid Autonomous Cellular Robots

Alapan, Y., Yasa, O., Yigit, B., Yasa, I. C., Erkoc, P., Sitti, M.

Annual Review of Control, Robotics, and Autonomous Systems, 2019 (article)

pi

[BibTex]

[BibTex]


Tailored Magnetic Springs for Shape-Memory Alloy Actuated Mechanisms in Miniature Robots
Tailored Magnetic Springs for Shape-Memory Alloy Actuated Mechanisms in Miniature Robots

Woodward, M. A., Sitti, M.

IEEE Transactions on Robotics, 35, 2019 (article)

Abstract
Animals can incorporate large numbers of actuators because of the characteristics of muscles; whereas, robots cannot, as typical motors tend to be large, heavy, and inefficient. However, shape-memory alloys (SMA), materials that contract during heating because of change in their crystal structure, provide another option. SMA, though, is unidirectional and therefore requires an additional force to reset (extend) the actuator, which is typically provided by springs or antagonistic actuation. These strategies, however, tend to limit the actuator's work output and functionality as their force-displacement relationships typically produce increasing resistive force with limited variability. In contrast, magnetic springs-composed of permanent magnets, where the interaction force between magnets mimics a spring force-have much more variable force-displacement relationships and scale well with SMA. However, as of yet, no method for designing magnetic springs for SMA-actuators has been demonstrated. Therefore, in this paper, we present a new methodology to tailor magnetic springs to the characteristics of these actuators, with experimental results both for the device and robot-integrated SMA-actuators. We found magnetic building blocks, based on sets of permanent magnets, which are well-suited to SMAs and have the potential to incorporate features such as holding force, state transitioning, friction minimization, auto-alignment, and self-mounting. We show magnetic springs that vary by more than 3 N in 750 $\mu$m and two SMA-actuated devices that allow the MultiMo-Bat to reach heights of up to 4.5 m without, and 3.6 m with, integrated gliding airfoils. Our results demonstrate the potential of this methodology to add previously impossible functionality to smart material actuators. We anticipate this methodology will inspire broader consideration of the use of magnetic springs in miniature robots and further study of the potential of tailored magnetic springs throughout mechanical systems.

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DOI [BibTex]


Magnetically Actuated Soft Capsule Endoscope for Fine-Needle Biopsy
Magnetically Actuated Soft Capsule Endoscope for Fine-Needle Biopsy

Son, D., Gilbert, H., Sitti, M.

Soft robotics, Mary Ann Liebert, Inc., publishers 140 Huguenot Street, 3rd Floor New …, 2019 (article)

pi

[BibTex]

[BibTex]


Thrust and Hydrodynamic Efficiency of the Bundled Flagella
Thrust and Hydrodynamic Efficiency of the Bundled Flagella

Danis, U., Rasooli, R., Chen, C., Dur, O., Sitti, M., Pekkan, K.

Micromachines, 10, 2019 (article)

pi

[BibTex]

[BibTex]


Tactile Roughness Perception of Virtual Gratings by Electrovibration
Tactile Roughness Perception of Virtual Gratings by Electrovibration

Isleyen, A., Vardar, Y., Basdogan, C.

IEEE Transactions on Haptics, 2019 (article) Accepted

hi

[BibTex]

[BibTex]


Autonomous Identification and Goal-Directed Invocation of Event-Predictive Behavioral Primitives
Autonomous Identification and Goal-Directed Invocation of Event-Predictive Behavioral Primitives

Gumbsch, C., Butz, M. V., Martius, G.

IEEE Transactions on Cognitive and Developmental Systems, 2019 (article)

Abstract
Voluntary behavior of humans appears to be composed of small, elementary building blocks or behavioral primitives. While this modular organization seems crucial for the learning of complex motor skills and the flexible adaption of behavior to new circumstances, the problem of learning meaningful, compositional abstractions from sensorimotor experiences remains an open challenge. Here, we introduce a computational learning architecture, termed surprise-based behavioral modularization into event-predictive structures (SUBMODES), that explores behavior and identifies the underlying behavioral units completely from scratch. The SUBMODES architecture bootstraps sensorimotor exploration using a self-organizing neural controller. While exploring the behavioral capabilities of its own body, the system learns modular structures that predict the sensorimotor dynamics and generate the associated behavior. In line with recent theories of event perception, the system uses unexpected prediction error signals, i.e., surprise, to detect transitions between successive behavioral primitives. We show that, when applied to two robotic systems with completely different body kinematics, the system manages to learn a variety of complex behavioral primitives. Moreover, after initial self-exploration the system can use its learned predictive models progressively more effectively for invoking model predictive planning and goal-directed control in different tasks and environments.

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arXiv PDF video link (url) DOI Project Page [BibTex]


The near and far of a pair of magnetic capillary disks
The near and far of a pair of magnetic capillary disks

Koens, L., Wang, W., Sitti, M., Lauga, E.

Soft Matter, 2019 (article)

pi

[BibTex]

[BibTex]


Multifarious Transit Gates for Programmable Delivery of Bio‐functionalized Matters
Multifarious Transit Gates for Programmable Delivery of Bio‐functionalized Matters

Hu, X., Torati, S. R., Kim, H., Yoon, J., Lim, B., Kim, K., Sitti, M., Kim, C.

Small, Wiley Online Library, 2019 (article)

pi

[BibTex]

[BibTex]


Multi-functional soft-bodied jellyfish-like swimming
Multi-functional soft-bodied jellyfish-like swimming

Ren, Z., Hu, W., Dong, X., Sitti, M.

Nature communications, 10, 2019 (article)

pi

[BibTex]


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Welcome to Progress in Biomedical Engineering

Sitti, M.

Progress in Biomedical Engineering, 1, IOP Publishing, 2019 (article)

pi

[BibTex]

[BibTex]


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Machine Learning for Haptics: Inferring Multi-Contact Stimulation From Sparse Sensor Configuration

Sun, H., Martius, G.

Frontiers in Neurorobotics, 13, pages: 51, 2019 (article)

Abstract
Robust haptic sensation systems are essential for obtaining dexterous robots. Currently, we have solutions for small surface areas such as fingers, but affordable and robust techniques for covering large areas of an arbitrary 3D surface are still missing. Here, we introduce a general machine learning framework to infer multi-contact haptic forces on a 3D robot’s limb surface from internal deformation measured by only a few physical sensors. The general idea of this framework is to predict first the whole surface deformation pattern from the sparsely placed sensors and then to infer number, locations and force magnitudes of unknown contact points. We show how this can be done even if training data can only be obtained for single-contact points using transfer learning at the example of a modified limb of the Poppy robot. With only 10 strain-gauge sensors we obtain a high accuracy also for multiple-contact points. The method can be applied to arbitrarily shaped surfaces and physical sensor types, as long as training data can be obtained.

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link (url) DOI [BibTex]


Mechanics of a pressure-controlled adhesive membrane for soft robotic gripping on curved surfaces
Mechanics of a pressure-controlled adhesive membrane for soft robotic gripping on curved surfaces

Song, S., Drotlef, D., Paik, J., Majidi, C., Sitti, M.

Extreme Mechanics Letters, Elsevier, 2019 (article)

pi

[BibTex]


Graphene oxide synergistically enhances antibiotic efficacy in Vancomycin resistance Staphylococcus aureus
Graphene oxide synergistically enhances antibiotic efficacy in Vancomycin resistance Staphylococcus aureus

Singh, V., Kumar, V., Kashyap, S., Singh, A. V., Kishore, V., Sitti, M., Saxena, P. S., Srivastava, A.

ACS Applied Bio Materials, ACS Publications, 2019 (article)

pi

[BibTex]

[BibTex]


Review of emerging concepts in nanotoxicology: opportunities and challenges for safer nanomaterial design
Review of emerging concepts in nanotoxicology: opportunities and challenges for safer nanomaterial design

Singh, A. V., Laux, P., Luch, A., Sudrik, C., Wiehr, S., Wild, A., Santamauro, G., Bill, J., Sitti, M.

Toxicology Mechanisms and Methods, 2019 (article)

pi

[BibTex]

[BibTex]


Multifunctional and biodegradable self-propelled protein motors
Multifunctional and biodegradable self-propelled protein motors

Pena-Francesch, A., Giltinan, J., Sitti, M.

Nature communications, 10, Nature Publishing Group, 2019 (article)

pi

[BibTex]

[BibTex]


Automated Generation of Reactive Programs from Human Demonstration for Orchestration of Robot Behaviors
Automated Generation of Reactive Programs from Human Demonstration for Orchestration of Robot Behaviors

Berenz, V., Bjelic, A., Mainprice, J.

ArXiv, 2019 (article)

Abstract
Social robots or collaborative robots that have to interact with people in a reactive way are difficult to program. This difficulty stems from the different skills required by the programmer: to provide an engaging user experience the behavior must include a sense of aesthetics while robustly operating in a continuously changing environment. The Playful framework allows composing such dynamic behaviors using a basic set of action and perception primitives. Within this framework, a behavior is encoded as a list of declarative statements corresponding to high-level sensory-motor couplings. To facilitate non-expert users to program such behaviors, we propose a Learning from Demonstration (LfD) technique that maps motion capture of humans directly to a Playful script. The approach proceeds by identifying the sensory-motor couplings that are active at each step using the Viterbi path in a Hidden Markov Model (HMM). Given these activation patterns, binary classifiers called evaluations are trained to associate activations to sensory data. Modularity is increased by clustering the sensory-motor couplings, leading to a hierarchical tree structure. The novelty of the proposed approach is that the learned behavior is encoded not in terms of trajectories in a task space, but as couplings between sensory information and high-level motor actions. This provides advantages in terms of behavioral generalization and reactivity displayed by the robot.

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Support Video link (url) [BibTex]


Mobile microrobots for active therapeutic delivery
Mobile microrobots for active therapeutic delivery

Erkoc, P., Yasa, I. C., Ceylan, H., Yasa, O., Alapan, Y., Sitti, M.

Advanced Therapeutics, Wiley Online Library, 2019 (article)

pi

[BibTex]

[BibTex]


Shape-encoded dynamic assembly of mobile micromachines
Shape-encoded dynamic assembly of mobile micromachines

Alapan, Y., Yigit, B., Beker, O., Demirörs, A. F., Sitti, M.

Nature, 18, 2019 (article)

pi

[BibTex]

[BibTex]


Microfluidics Integrated Lithography‐Free Nanophotonic Biosensor for the Detection of Small Molecules
Microfluidics Integrated Lithography‐Free Nanophotonic Biosensor for the Detection of Small Molecules

Sreekanth, K. V., Sreejith, S., Alapan, Y., Sitti, M., Lim, C. T., Singh, R.

Advanced Optical Materials, 2019 (article)

pi

[BibTex]

[BibTex]


ENGINEERING Bio-inspired robotic collectives
ENGINEERING Bio-inspired robotic collectives

Sitti, M.

Nature, 567, pages: 314-315, Macmillan Publishers Ltd., London, England, 2019 (article)

pi

[BibTex]

[BibTex]


Peptide-Induced Biomineralization of Tin Oxide (SnO2) Nanoparticles for Antibacterial Applications
Peptide-Induced Biomineralization of Tin Oxide (SnO2) Nanoparticles for Antibacterial Applications

Singh, A. V., Jahnke, T., Xiao, Y., Wang, S., Yu, Y., David, H., Richter, G., Laux, P., Luch, A., Srivastava, A., Saxena, P. S., Bill, J., Sitti, M.

Journal of nanoscience and nanotechnology, 19, American Scientific Publishers, 2019 (article)

pi

[BibTex]

[BibTex]


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Electromechanical actuation of dielectric liquid crystal elastomers for soft robotics

Davidson, Z., Shahsavan, H., Guo, Y., Hines, L., Xia, Y., Yang, S., Sitti, M.

Bulletin of the American Physical Society, APS, 2019 (article)

pi

[BibTex]

[BibTex]


Learning to Navigate Endoscopic Capsule Robots
Learning to Navigate Endoscopic Capsule Robots

Turan, M., Almalioglu, Y., Gilbert, H. B., Mahmood, F., Durr, N. J., Araujo, H., Sarı, A. E., Ajay, A., Sitti, M.

IEEE Robotics and Automation Letters, 4, 2019 (article)

pi

[BibTex]

[BibTex]


Order and Information in the Phases of a Torque-driven Artificial Collective System
Order and Information in the Phases of a Torque-driven Artificial Collective System

Wang, W., Gardi, G., Kishore, V., Koens, L., Son, D., Gilbert, H., Harwani, P., Lauga, E., Sitti, M.

arXiv preprint arXiv:1910.11226, 2019 (article)

pi

[BibTex]

[BibTex]

2016


A New Perspective and Extension of the Gaussian Filter
A New Perspective and Extension of the Gaussian Filter

Wüthrich, M., Trimpe, S., Garcia Cifuentes, C., Kappler, D., Schaal, S.

The International Journal of Robotics Research, 35(14):1731-1749, December 2016 (article)

Abstract
The Gaussian Filter (GF) is one of the most widely used filtering algorithms; instances are the Extended Kalman Filter, the Unscented Kalman Filter and the Divided Difference Filter. The GF represents the belief of the current state by a Gaussian distribution, whose mean is an affine function of the measurement. We show that this representation can be too restrictive to accurately capture the dependences in systems with nonlinear observation models, and we investigate how the GF can be generalized to alleviate this problem. To this end, we view the GF as the solution to a constrained optimization problem. From this new perspective, the GF is seen as a special case of a much broader class of filters, obtained by relaxing the constraint on the form of the approximate posterior. On this basis, we outline some conditions which potential generalizations have to satisfy in order to maintain the computational efficiency of the GF. We propose one concrete generalization which corresponds to the standard GF using a pseudo measurement instead of the actual measurement. Extending an existing GF implementation in this manner is trivial. Nevertheless, we show that this small change can have a major impact on the estimation accuracy.

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PDF DOI Project Page [BibTex]

2016


PDF DOI Project Page [BibTex]


Bioengineered and biohybrid bacteria-based systems for drug delivery
Bioengineered and biohybrid bacteria-based systems for drug delivery

Hosseinidoust, Z., Mostaghaci, B., Yasa, O., Park, B., Singh, A. V., Sitti, M.

Advanced Drug Delivery Reviews, 106, pages: 27-44, Elsevier, November 2016 (article)

Abstract
The use of bacterial cells as agents of medical therapy has a long history. Research that was ignited over a century ago with the accidental infection of cancer patients has matured into a platform technology that offers the promise of opening up new potential frontiers in medical treatment. Bacterial cells exhibit unique characteristics that make them well-suited as smart drug delivery agents. Our ability to genetically manipulate the molecular machinery of these cells enables the customization of their therapeutic action as well as its precise tuning and spatio-temporal control, allowing for the design of unique, complex therapeutic functions, unmatched by current drug delivery systems. Early results have been promising, but there are still many important challenges that must be addressed. We present a review of promises and challenges of employing bioengineered bacteria in drug delivery systems and introduce the biohybrid design concept as a new additional paradigm in bacteria-based drug delivery.

pi

DOI Project Page [BibTex]

DOI Project Page [BibTex]