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2016


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Bioengineered and biohybrid bacteria-based systems for drug delivery

Hosseinidoust, Z., Mostaghaci, B., Yasa, O., Park, B., Singh, A. V., Sitti, M.

Advanced Drug Delivery Reviews, 106, pages: 27-44, Elsevier, November 2016 (article)

Abstract
The use of bacterial cells as agents of medical therapy has a long history. Research that was ignited over a century ago with the accidental infection of cancer patients has matured into a platform technology that offers the promise of opening up new potential frontiers in medical treatment. Bacterial cells exhibit unique characteristics that make them well-suited as smart drug delivery agents. Our ability to genetically manipulate the molecular machinery of these cells enables the customization of their therapeutic action as well as its precise tuning and spatio-temporal control, allowing for the design of unique, complex therapeutic functions, unmatched by current drug delivery systems. Early results have been promising, but there are still many important challenges that must be addressed. We present a review of promises and challenges of employing bioengineered bacteria in drug delivery systems and introduce the biohybrid design concept as a new additional paradigm in bacteria-based drug delivery.

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DOI Project Page [BibTex]

2016


DOI Project Page [BibTex]


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An electro-active polymer based lens module for dynamically varying focal system

Yun, S., Park, S., Nam, S., Park, B., Park, S. K., Mun, S., Lim, J. M., Kyung, K.

Applied Physics Letters, 109(14):141908, October 2016 (article)

Abstract
We demonstrate a polymer-based active-lens module allowing a dynamic focus controllable optical system with a wide tunable range. The active-lens module is composed of parallelized two active- lenses with a convex and a concave shaped hemispherical lens structure, respectively. Under opera- tion with dynamic input voltage signals, each active-lens produces translational movement bi-directionally responding to a hybrid driving force that is a combination of an electro-active response of a thin dielectric elastomer membrane and an electro-static attraction force. Since the proposed active lens module widely modulates a gap-distance between lens-elements, an optical system based on the active-lens module provides widely-variable focusing for selective imaging of objects in arbitrary position.

hi

link (url) DOI [BibTex]

link (url) DOI [BibTex]


Thumb xl 07293677
A 5-D localization method for a magnetically manipulated untethered robot using a 2-D array of Hall-effect sensors

Son, D., Yim, S., Sitti, M.

IEEE/ASME Transactions on Mechatronics, 21(2):708-716, IEEE, October 2016 (article)

Abstract
This paper introduces a new five-dimensional localization method for an untethered meso-scale magnetic robot, which is manipulated by a computer-controlled electromagnetic system. The developed magnetic localization setup is a two-dimensional array of mono-axial Hall-effect sensors, which measure the perpendicular magnetic fields at their given positions. We introduce two steps for localizing a magnetic robot more accurately. First, the dipole modeled magnetic field of the electromagnet is subtracted from the measured data in order to determine the robot's magnetic field. Secondly, the subtracted magnetic field is twice differentiated in the perpendicular direction of the array, so that the effect of the electromagnetic field in the localization process is minimized. Five variables regarding the position and orientation of the robot are determined by minimizing the error between the measured magnetic field and the modeled magnetic field in an optimization method. The resulting position error is 2.1±0.8 mm and angular error is 6.7±4.3° within the applicable range (5 cm) of magnetic field sensors at 200 Hz. The proposed localization method would be used for the position feedback control of untethered magnetic devices or robots for medical applications in the future.

pi

DOI Project Page [BibTex]

DOI Project Page [BibTex]


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High-Performance Multiresponsive Paper Actuators

Amjadi, M., Sitti, M.

ACS Nano, 10(11):10202-10210, American Chemical Society, October 2016 (article)

Abstract
There is an increasing demand for soft actuators because of their importance in soft robotics, artificial muscles, biomimetic devices, and beyond. However, the development of soft actuators capable of low-voltage operation, powerful actuation, and programmable shape-changing is still challenging. In this work, we propose programmable bilayer actuators that operate based on the large hygroscopic contraction of the copy paper and simultaneously large thermal expansion of the polypropylene film upon increasing the temperature. The electrothermally activated bending actuators can function with low voltages (≤ 8 V), low input electric power per area (P ≤ 0.14 W cm–2), and low temperature changes (≤ 35 °C). They exhibit reversible shape-changing behavior with curvature radii up to 1.07 cm–1 and bending angle of 360°, accompanied by powerful actuation. Besides the electrical activation, they can be powered by humidity or light irradiation. We finally demonstrate the use of our paper actuators as a soft gripper robot and a lightweight paper wing for aerial robotics.

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DOI Project Page Project Page [BibTex]

DOI Project Page Project Page [BibTex]


Thumb xl publications toc
Programmable assembly of heterogeneous microparts by an untethered mobile capillary microgripper

Giltinan, J., Diller, E., Sitti, M.

Lab on a Chip, 16(22):4445-4457, Royal Society of Chemistry, October 2016 (article)

Abstract
At the sub-millimeter scale, capillary forces enable robust and reversible adhesion between biological organisms and varied substrates. Current human-engineered mobile untethered micromanipulation systems rely on forces which scale poorly or utilize gripper-part designs that promote manipulation. Capillary forces, alternatively, are dependent upon the surface chemistry (which is scale independent) and contact perimeter, which conforms to the part surface. We report a mobile capillary microgripper that is able to pick and place parts of various materials and geometries, and is thus ideal for microassembly tasks that cannot be accomplished by large tethered manipulators. We achieve the programmable assembly of sub-millimeter parts in an enclosed three-dimensional aqueous environment by creating a capillary bridge between the targeted part and a synthetic, untethered, mobile body. The parts include both hydrophilic and hydrophobic components: hydrogel, kapton, human hair, and biological tissue. The 200 μm untethered system can be controlled with five-degrees-of-freedom and advances progress towards autonomous desktop manufacturing for tissue engineering, complex micromachines, microfluidic devices, and meta-materials.

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DOI Project Page [BibTex]

DOI Project Page [BibTex]


Thumb xl 5fc6a94719a2ed61820a6fd031f53c39682a1f157b1c10c35d5d4c88d087d90e
Composition-dependent underwater adhesion of catechol-bearing hydrogels

Wu, H., Sariola, V., Zhao, J., Ding, H., Sitti, M., Bettinger, C. J.

Polymer International, 65(11):1355-1359, John Wiley & Sons, Ltd, September 2016 (article)

Abstract
Interfacial adhesion-mediated transfer printing processes can integrate functional electronic microstructures with polymeric substrates that are bendable and stretchable. Transfer printing has also been extended to catechol-bearing adhesive hydrogels. This study presents indentation adhesion tests between catechol-bearing hydrogel substrates with catechol concentrations varying from 0 to 10% (mol/mol) and thin-film materials commonly used in microelectronic fabrication including polymers, noble metals and oxides. The results indicate that the interfacial adhesion of catechol-bearing hydrogels is positively correlated with the concentration of catechol-bearing monomers as well as the retraction velocity during transfer printing. This study can inform transfer printing processes for microfabricated structures to compliant hydrated substrates such as hygroscopic monomers, mesoporous polymer networks and hydrogels. © 2016 Society of Chemical Industry

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DOI [BibTex]

DOI [BibTex]


Thumb xl singh et al 2016 advanced healthcare materials
Bacteria-Driven Particles: Patterned and Specific Attachment of Bacteria on Biohybrid Bacteria-Driven Microswimmers (Adv. Healthcare Mater. 18/2016)

Singh, A. V., Sitti, M.

Advanced Healthcare Materials, 5(18):2306-2306, September 2016 (article)

Abstract
On page 2325, Ajay Vikram Singh and Metin Sitti propose a facile surface patterning technique and a specific, strong biotin–streptavidin bonding of bacteria on patterned surfaces to fabricate Janus particles that are propelled by the attached bacteria. Such bacteria-driven Janus microswimmers could be used for future medicine in targeted drug delivery and environmental remediation.

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DOI Project Page [BibTex]


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Wrinkle structures formed by formulating UV-crosslinkable liquid prepolymers

Park, S. K., Kwark, Y., Nam, S., Park, S., Park, B., Yun, S., Moon, J., Lee, J., Yu, B., Kyung, K.

Polymer, 99, pages: 447-452, September 2016 (article)

Abstract
Artificial wrinkles have recently been in the spotlight due to their potential use in high-tech applications. A spontaneously wrinkled film can be fabricated from UV-crosslinkable liquid prepolymers. Here, we controlled the wrinkle formation by simply formulating two UV-crosslinkable liquid prepolymers, tetraethylene glycol bis(4-ethenyl-2,3,5,6-tetrafluorophenyl) ether (TEGDSt) and tetraethylene glycol diacrylate (TEGDA). The wrinkles were formed from the TEGDSt/TEGDA formulated prepolymer layers containing up to 30 wt% of TEGDA. The wrinkle formation depended upon the rate of photo-crosslinking reaction of the formulated prepolymers. The first order apparent rate constant, kapp, was between ca. 5.7 × 10−3 and 12.2 × 10−3 s−1 for the wrinkle formation. The wrinkle structures were modulated within the kapp mainly due to variation in the extent of shrinkage of the formulated prepolymer layers with the content of TEGDA

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link (url) DOI [BibTex]

link (url) DOI [BibTex]


Thumb xl publications toc
The effect of temperature and humidity on adhesion of a gecko-inspired adhesive: implications for the natural system

Stark, A. Y., Klittich, M. R., Sitti, M., Niewiarowski, P. H., Dhinojwala, A.

Scientific Reports, 6, pages: 30936, Nature Publishing Group, August 2016 (article)

Abstract
The adhesive system of geckos has inspired hundreds of synthetic adhesives. While this system has been used relentlessly as a source of inspiration, less work has been done in reverse, where synthetics are used to test questions and hypotheses about the natural system. Here we take such an approach. We tested shear adhesion of a mushroom-tipped synthetic gecko adhesive under conditions that produced perplexing results in the natural adhesive system. Synthetic samples were tested at two temperatures (12 °C and 32 °C) and four different humidity levels (30%, 55%, 70%, and 80% RH). Surprisingly, adhesive performance of the synthetic samples matched that of living geckos, suggesting that uncontrolled parameters in the natural system, such as surface chemistry and material changes, may not be as influential in whole-animal performance as previously thought. There was one difference, however, when comparing natural and synthetic adhesive performance. At 12 °C and 80% RH, adhesion of the synthetic structures was lower than expected based on the natural system’s performance. Our approach highlights a unique opportunity for both biologists and material scientists, where new questions and hypotheses can be fueled by joint comparisons of the natural and synthetic systems, ultimately improving knowledge of both.

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DOI [BibTex]

DOI [BibTex]


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Magnetic propulsion of robotic sperms at low-Reynolds number

Khalil, I. S., Fatih Tabak, A., Klingner, A., Sitti, M.

Applied Physics Letters, 109(3):033701, AIP Publishing, July 2016 (article)

Abstract
We investigate the microswimming behaviour of robotic sperms in viscous fluids. These robotic sperms are fabricated from polystyrene dissolved in dimethyl formamide and iron-oxide nanoparticles. This composition allows the nanoparticles to be concentrated within the bead of the robotic sperm and provide magnetic dipole, whereas the flexibility of the ultra-thin tail enables flagellated locomotion using magnetic fields in millitesla range. We show that these robotic sperms have similar morphology and swimming behaviour to those of sperm cells. Moreover, we show experimentally that our robotic sperms swim controllably at an average speed of approximately one body length per second (around 125 μm s−1), and they are relatively faster than the microswimmers that depend on planar wave propulsion in low-Reynolds number fluids.

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DOI [BibTex]

DOI [BibTex]


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Six-degree-of-freedom magnetic actuation for wireless microrobotics

Diller, E., Giltinan, J., Lum, G. Z., Ye, Z., Sitti, M.

The International Journal of Robotics Research, 35(1-3):114-128, SAGE Publications Sage UK: London, England, June 2016 (article)

Abstract
Existing remotely actuated magnetic microrobots exhibit a maximum of only five-degree-of-freedom (DOF) actuation, as creation of a driving torque about the microrobot magnetization axis is not achievable. This lack of full orientation control limits the effectiveness of existing microrobots for precision tasks of object manipulation and orientation for advanced medical, biological and micromanufacturing applications. This paper presents a magnetic actuation method that allows remotely powered microrobots to achieve full six-DOF actuation by considering the case of a non-uniform magnetization profile within the microrobot body. This non-uniform magnetization allows for additional rigid-body torques to be induced from magnetic forces via a moment arm. A general analytical model presents the working principle for continuous and discrete magnetization profiles, which is applied to permanent or non-permanent (soft) magnet bodies. Several discrete-magnetization designs are also presented which possess reduced coupling between magnetic forces and induced rigid-body torques. Design guidelines are introduced which can be followed to ensure that a magnetic microrobot design is capable of six-DOF actuation. A simple permanent-magnet prototype is fabricated and used to quantitatively demonstrate the accuracy of the analytical model in a constrained-DOF environment and qualitatively for free motion in a viscous liquid three-dimensional environment. Results show that desired forces and torques can be created with high precision and limited parasitic actuation, allowing for full six-DOF actuation using limited feedback control

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DOI [BibTex]

DOI [BibTex]


Thumb xl ye et al 2016 advanced materials
Gallium Adhesion: Phase Change of Gallium Enables Highly Reversible and Switchable Adhesion (Adv. Mater. 25/2016)

Ye, Z., Lum, G. Z., Song, S., Rich, S., Sitti, M.

Advanced Materials, 28(25):5087-5087, May 2016 (article)

Abstract
Gallium exhibits highly reversible and switchable adhesion when it undergoes a solid–liquid phase transition. The robustness of gallium is notable as it exhibits strong performance on a wide range of smooth and rough surfaces, under both dry and wet conditions. Gallium may therefore find numerous applications in transfer printing, robotics, electronic packaging, and biomedicine.

pi

DOI [BibTex]


Thumb xl singh et al 2016 advanced healthcare materials
Patterned and Specific Attachment of Bacteria on Biohybrid Bacteria-Driven Microswimmers

Singh, A. V., Sitti, M.

Advanced Healthcare Materials, 5(18):2325-2331, May 2016 (article)

Abstract
A surface patterning technique and a specific and strong biotin–streptavidin bonding of bacteria on patterned surfaces are proposed to fabricate Janus particles that are propelled by the attached bacteria. Bacteria-driven Janus microswimmers with diameters larger than 3 μm show enhanced mean propulsion speed. Such microswimmers could be used for future applications such as targeted drug delivery and environmental remediation.

pi

DOI [BibTex]


Thumb xl pnas 2016 lum 1608193113 2
Shape-programmable magnetic soft matter

Lum, G. Z., Ye, Z., Dong, X., Marvi, H., Erin, O., Hu, W., Sitti, M.

Proceedings of the National Academy of Sciences, 113(41):E6007–E6015, National Acad Sciences, May 2016 (article)

Abstract
Shape-programmable matter is a class of active materials whose geometry can be controlled to potentially achieve mechanical functionalities beyond those of traditional machines. Among these materials, magnetically actuated matter is particularly promising for achieving complex time-varying shapes at small scale (overall dimensions smaller than 1 cm). However, previous work can only program these materials for limited applications, as they rely solely on human intuition to approximate the required magnetization profile and actuating magnetic fields for their materials. Here, we propose a universal programming methodology that can automatically generate the required magnetization profile and actuating fields for soft matter to achieve new time-varying shapes. The universality of the proposed method can therefore inspire a vast number of miniature soft devices that are critical in robotics, smart engineering surfaces and materials, and biomedical devices. Our proposed method includes theoretical formulations, computational strategies, and fabrication procedures for programming magnetic soft matter. The presented theory and computational method are universal for programming 2D or 3D time-varying shapes, whereas the fabrication technique is generic only for creating planar beams. Based on the proposed programming method, we created a jellyfish-like robot, a spermatozoid-like undulating swimmer, and an artificial cilium that could mimic the complex beating patterns of its biological counterpart.

pi

DOI [BibTex]

DOI [BibTex]


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Objective assessment of robotic surgical skill using instrument contact vibrations

Gomez, E. D., Aggarwal, R., McMahan, W., Bark, K., Kuchenbecker, K. J.

Surgical Endoscopy, 30(4):1419-1431, 2016 (article)

hi

[BibTex]

[BibTex]


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Inflated soft actuators with reversible stable deformations

Hines, L., Petersen, K., Sitti, M.

Advanced Materials, 28(19):3690-3696, March 2016 (article)

Abstract
Most soft robotic systems are currently dependent on bulky compressors or pumps. A soft actuation method is presented combining hyperelastic membranes and dielectric elastomer actuators to switch between stable deformations of sealed chambers. This method is capable of large repeatable deformations, and has a number of stable states proportional to the number of actuatable membranes in the chamber.

pi

DOI Project Page [BibTex]


Thumb xl publications toc
Chemotaxis of bio-hybrid multiple bacteria-driven microswimmers

Zhuang, J., Sitti, M.

Scientific reports, 6, pages: 32135, Nature Publishing Group, March 2016 (article)

Abstract
In this study, in a bio-hybrid microswimmer system driven by multiple Serratia marcescens bacteria, we quantify the chemotactic drift of a large number of microswimmers towards L-serine and elucidate the associated collective chemotaxis behavior by statistical analysis of over a thousand swimming trajectories of the microswimmers. The results show that the microswimmers have a strong heading preference for moving up the L-serine gradient, while their speed does not change considerably when moving up and down the gradient; therefore, the heading bias constitutes the major factor that produces the chemotactic drift. The heading direction of a microswimmer is found to be significantly more persistent when it moves up the L-serine gradient than when it travels down the gradient; this effect causes the apparent heading preference of the microswimmers and is the crucial reason that enables the seemingly cooperative chemotaxis of multiple bacteria on a microswimmer. In addition, we find that their chemotactic drift velocity increases superquadratically with their mean swimming speed, suggesting that chemotaxis of bio-hybrid microsystems can be enhanced by designing and building faster microswimmers. Such bio-hybrid microswimmers with chemotactic steering capability may find future applications in targeted drug delivery, bioengineering, and lab-on-a-chip devices.

pi

DOI Project Page [BibTex]

DOI Project Page [BibTex]


Thumb xl publications toc
Targeted drug delivery and imaging using mobile milli/microrobots: A promising future towards theranostic pharmaceutical design

Vikram Singh, A., Sitti, M.

Current Pharmaceutical Design, 22(11):1418-1428, Bentham Science Publishers, March 2016 (article)

Abstract
Miniature untethered medical robots have been receiving growing attention due to technological advances in microactuation, microsensors, and microfabrication and have significant potential to reduce the invasiveness and improve the accessibility of medical devices into unprecedented small spaces inside the human body. In this review, we discuss therapeutic and diagnostic applications of untethered medical microrobots. Wirelessly controlled milli/microrobots with integrated sensors are revolutionizing micromanipulation based medical interventions and are enabling doctors to perform minimally invasive procedures not possible before. 3D fabrication technologies enabling milli/microrobot fabrication at the single cell scale are empowering high-resolution visual imaging and in vivo manipulation capabilities. Swallowable millirobots and injectabale ocular microrobots allow the gastric ulcer imaging, and performance of vitreoretinal microsurgery at previously inaccessible ocular sites. Many invasive excision and incision based diagnostic biopsy, prostrate, and nephrolgical procedures can be performed minimally or almost noninvasively due to recent advancements in microrobotic technology. Advances in biohybrid microrobot systems are pushing microrobotic systems even smaller, using biological cells as on-board microactuators and microsensors using the chemical energy. Such microrobotic systems could be used for local targeted delivery of imaging contrast agents, drugs, genes, and mRNA, minimally invasive surgery, and cell micromanipulation in the near future.

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link (url) [BibTex]


Thumb xl publications toc
Parallel microcracks-based ultrasensitive and highly stretchable strain sensors

Amjadi, M., Turan, M., Clementson, C. P., Sitti, M.

ACS Applied Materials \& Interfaces, 8(8):5618-5626, American Chemical Society, Febuary 2016 (article)

Abstract
There is an increasing demand for flexible, skin-attachable, and wearable strain sensors due to their various potential applications. However, achieving strain sensors with both high sensitivity and high stretchability is still a grand challenge. Here, we propose highly sensitive and stretchable strain sensors based on the reversible microcrack formation in composite thin films. Controllable parallel microcracks are generated in graphite thin films coated on elastomer films. Sensors made of graphite thin films with short microcracks possess high gauge factors (maximum value of 522.6) and stretchability (ε ≥ 50%), whereas sensors with long microcracks show ultrahigh sensitivity (maximum value of 11 344) with limited stretchability (ε ≤ 50%). We demonstrate the high performance strain sensing of our sensors in both small and large strain sensing applications such as human physiological activity recognition, human body large motion capturing, vibration detection, pressure sensing, and soft robotics.

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DOI [BibTex]

DOI [BibTex]


Thumb xl amjadi et al 2016 advanced functional materials
Stretchable, Skin-Mountable, and Wearable Strain Sensors and Their Potential Applications: A Review

Amjadi, M., Kyung, K., Park, I., Sitti, M.

Advanced Functional Materials, 26, pages: 1678-1698, Febuary 2016 (article)

Abstract
There is a growing demand for flexible and soft electronic devices. In particular, stretchable, skin-mountable, and wearable strain sensors are needed for several potential applications including personalized health-monitoring, human motion detection, human-machine interfaces, soft robotics, and so forth. This Feature Article presents recent advancements in the development of flexible and stretchable strain sensors. The article shows that highly stretchable strain sensors are successfully being developed by new mechanisms such as disconnection between overlapped nanomaterials, crack propagation in thin films, and tunneling effect, different from traditional strain sensing mechanisms. Strain sensing performances of recently reported strain sensors are comprehensively studied and discussed, showing that appropriate choice of composite structures as well as suitable interaction between functional nanomaterials and polymers are essential for the high performance strain sensing. Next, simulation results of piezoresistivity of stretchable strain sensors by computational models are reported. Finally, potential applications of flexible strain sensors are described. This survey reveals that flexible, skin-mountable, and wearable strain sensors have potential in diverse applications while several grand challenges have to be still overcome.

pi

DOI [BibTex]

DOI [BibTex]


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Cutaneous Feedback of Fingertip Deformation and Vibration for Palpation in Robotic Surgery

Pacchierotti, C., Prattichizzo, D., Kuchenbecker, K. J.

IEEE Transactions on Biomedical Engineering, 63(2):278-287, February 2016 (article)

hi

[BibTex]

[BibTex]


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Structure modulated electrostatic deformable mirror for focus and geometry control

Nam, S., Park, S., Yun, S., Park, B., Park, S. K., Kyung, K.

Optics Express, 24(1):55-66, OSA, January 2016 (article)

Abstract
We suggest a way to electrostatically control deformed geometry of an electrostatic deformable mirror (EDM) based on geometric modulation of a basement. The EDM is composed of a metal coated elastomeric membrane (active mirror) and a polymeric basement with electrode (ground). When an electrical voltage is applied across the components, the active mirror deforms toward the stationary basement responding to electrostatic attraction force in an air gap. Since the differentiated gap distance can induce change in electrostatic force distribution between the active mirror and the basement, the EDMs are capable of controlling deformed geometry of the active mirror with different basement structures (concave, flat, and protrusive). The modulation of the deformed geometry leads to significant change in the range of the focal length of the EDMs. Even under dynamic operations, the EDM shows fairly consistent and large deformation enough to change focal length in a wide frequency range (1~175 Hz). The geometric modulation of the active mirror with dynamic focus tunability can allow the EDM to be an active mirror lens for optical zoom devices as well as an optical component controlling field of view.

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link (url) DOI [BibTex]

link (url) DOI [BibTex]


Thumb xl b 07384529
Size optimization of a magnetic system for drug delivery with capsule robots

Munoz, F., Alici, G., Li, W., Sitti, M.

IEEE Transactions on Magnetics, 52(5):1-11, IEEE, January 2016 (article)

Abstract
In this paper, we present a methodology for the size optimization of an external magnetic system made of arc-shaped permanent magnets (ASMs). This magnetic system is able to remotely actuate a drug-release module embedded in a prototype of a capsule robot. The optimization of the magnetic system is carried out by using an accurate analytical model that is valid for any arbitrary dimensions of the ASMs. By using this analytical model, we perform parametric studies and conduct a statistical analysis [analysis of variance (ANOVA)] to investigate efficient ways to distribute the volume of the ASMs so that the dimensions and volume of the magnetic system are minimized while optimal flux densities and magnetic torques are obtained to actuate the drug delivery system (DDS). The ANOVA results, at 5% significance level, indicate that changes in the angular width followed by changes in the length of the ASMs have the highest impact on the magnetic linkage. Furthermore, our experimental results, which are in agreement with the analytical results, show that the size optimization of the magnetic system is effective for the actuation of the DDS in capsule robots.

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DOI [BibTex]

DOI [BibTex]


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Peripheral vs. central determinants of vibrotactile adaptation

Klöcker, A., Gueorguiev, D., Thonnard, J. L., Mouraux, A.

Journal of Neurophysiology, 115(2):685-691, 2016, PMID: 26581868 (article)

Abstract
Long-lasting mechanical vibrations applied to the skin induce a reversible decrease in the perception of vibration at the stimulated skin site. This phenomenon of vibrotactile adaptation has been studied extensively, yet there is still no clear consensus on the mechanisms leading to vibrotactile adaptation. In particular, the respective contributions of 1) changes affecting mechanical skin impedance, 2) peripheral processes, and 3) central processes are largely unknown. Here we used direct electrical stimulation of nerve fibers to bypass mechanical transduction processes and thereby explore the possible contribution of central vs. peripheral processes to vibrotactile adaptation. Three experiments were conducted. In the first, adaptation was induced with mechanical vibration of the fingertip (51- or 251-Hz vibration delivered for 8 min, at 40× detection threshold). In the second, we attempted to induce adaptation with transcutaneous electrical stimulation of the median nerve (51- or 251-Hz constant-current pulses delivered for 8 min, at 1.5× detection threshold). Vibrotactile detection thresholds were measured before and after adaptation. Mechanical stimulation induced a clear increase of vibrotactile detection thresholds. In contrast, thresholds were unaffected by electrical stimulation. In the third experiment, we assessed the effect of mechanical adaptation on the detection thresholds to transcutaneous electrical nerve stimuli, measured before and after adaptation. Electrical detection thresholds were unaffected by the mechanical adaptation. Taken together, our results suggest that vibrotactile adaptation is predominantly the consequence of peripheral mechanoreceptor processes and/or changes in biomechanical properties of the skin.

hi

link (url) DOI [BibTex]

link (url) DOI [BibTex]


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On designing an active tail for legged robots: simplifying control via decoupling of control objectives

Heim, S. W., Ajallooeian, M., Eckert, P., Vespignani, M., Ijspeert, A. J.

Industrial Robot: An International Journal, 43, pages: 338-346, Emerald Group Publishing Limited, 2016 (article)

dlg

Preprint [BibTex]

Preprint [BibTex]


Thumb xl screen shot 2017 06 14 at 3.04.03 pm
ATRIAS: Design and validation of a tether-free 3D-capable spring-mass bipedal robot

Hubicki, C., Grimes, J., Jones, M., Renjewski, D., Spröwitz, A., Abate, A., Hurst, J.

{The International Journal of Robotics Research}, 35(12):1497-1521, Sage Publications, Inc., Cambridge, MA, 2016 (article)

dlg

DOI Project Page [BibTex]

DOI Project Page [BibTex]


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Silent Expectations: Dynamic Causal Modeling of Cortical Prediction and Attention to Sounds That Weren’t

Chennu, S., Noreika, V., Gueorguiev, D., Shtyrov, Y., Bekinschtein, T. A., Henson, R.

Journal of Neuroscience, 36(32):8305-8316, Society for Neuroscience, 2016 (article)

Abstract
There is increasing evidence that human perception is realized by a hierarchy of neural processes in which predictions sent backward from higher levels result in prediction errors that are fed forward from lower levels, to update the current model of the environment. Moreover, the precision of prediction errors is thought to be modulated by attention. Much of this evidence comes from paradigms in which a stimulus differs from that predicted by the recent history of other stimuli (generating a so-called {\textquotedblleft}mismatch response{\textquotedblright}). There is less evidence from situations where a prediction is not fulfilled by any sensory input (an {\textquotedblleft}omission{\textquotedblright} response). This situation arguably provides a more direct measure of {\textquotedblleft}top-down{\textquotedblright} predictions in the absence of confounding {\textquotedblleft}bottom-up{\textquotedblright} input. We applied Dynamic Causal Modeling of evoked electromagnetic responses recorded by EEG and MEG to an auditory paradigm in which we factorially crossed the presence versus absence of {\textquotedblleft}bottom-up{\textquotedblright} stimuli with the presence versus absence of {\textquotedblleft}top-down{\textquotedblright} attention. Model comparison revealed that both mismatch and omission responses were mediated by increased forward and backward connections, differing primarily in the driving input. In both responses, modeling results suggested that the presence of attention selectively modulated backward {\textquotedblleft}prediction{\textquotedblright} connections. Our results provide new model-driven evidence of the pure top-down prediction signal posited in theories of hierarchical perception, and highlight the role of attentional precision in strengthening this prediction.SIGNIFICANCE STATEMENT Human auditory perception is thought to be realized by a network of neurons that maintain a model of and predict future stimuli. Much of the evidence for this comes from experiments where a stimulus unexpectedly differs from previous ones, which generates a well-known {\textquotedblleft}mismatch response.{\textquotedblright} But what happens when a stimulus is unexpectedly omitted altogether? By measuring the brain{\textquoteright}s electromagnetic activity, we show that it also generates an {\textquotedblleft}omission response{\textquotedblright} that is contingent on the presence of attention. We model these responses computationally, revealing that mismatch and omission responses only differ in the location of inputs into the same underlying neuronal network. In both cases, we show that attention selectively strengthens the brain{\textquoteright}s prediction of the future.

hi

link (url) DOI [BibTex]

link (url) DOI [BibTex]


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Touch uses frictional cues to discriminate flat materials

Gueorguiev, D., Bochereau, S., Mouraux, A., Hayward, V., Thonnard, J.

Scientific reports, 6, pages: 25553, Nature Publishing Group, 2016 (article)

hi

[BibTex]

[BibTex]


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Momentum Control with Hierarchical Inverse Dynamics on a Torque-Controlled Humanoid

Herzog, A., Rotella, N., Mason, S., Grimminger, F., Schaal, S., Righetti, L.

Autonomous Robots, 40(3):473-491, 2016 (article)

Abstract
Hierarchical inverse dynamics based on cascades of quadratic programs have been proposed for the control of legged robots. They have important benefits but to the best of our knowledge have never been implemented on a torque controlled humanoid where model inaccuracies, sensor noise and real-time computation requirements can be problematic. Using a reformulation of existing algorithms, we propose a simplification of the problem that allows to achieve real-time control. Momentum-based control is integrated in the task hierarchy and a LQR design approach is used to compute the desired associated closed-loop behavior and improve performance. Extensive experiments on various balancing and tracking tasks show very robust performance in the face of unknown disturbances, even when the humanoid is standing on one foot. Our results demonstrate that hierarchical inverse dynamics together with momentum control can be efficiently used for feedback control under real robot conditions.

am mg

link (url) DOI [BibTex]

2015


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Reducing Student Anonymity and Increasing Engagement

Kuchenbecker, K. J.

University of Pennsylvania Almanac, 62(18):8, November 2015 (article)

hi

[BibTex]

2015


[BibTex]


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Surgeons and Non-Surgeons Prefer Haptic Feedback of Instrument Vibrations During Robotic Surgery

Koehn, J. K., Kuchenbecker, K. J.

Surgical Endoscopy, 29(10):2970-2983, October 2015 (article)

hi

[BibTex]

[BibTex]


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Displaying Sensed Tactile Cues with a Fingertip Haptic Device

Pacchierotti, C., Prattichizzo, D., Kuchenbecker, K. J.

IEEE Transactions on Haptics, 8(4):384-396, October 2015 (article)

hi

[BibTex]

[BibTex]


Thumb xl publications toc
Experimental investigation of optimal adhesion of mushroomlike elastomer microfibrillar adhesives

Marvi, H., Song, S., Sitti, M.

Langmuir, 31(37):10119-10124, American Chemical Society, August 2015 (article)

Abstract
Optimal fiber designs for the maximal pull-off force have been indispensable for increasing the attachment performance of recently introduced gecko-inspired reversible micro/nanofibrillar adhesives. There are several theoretical studies on such optimal designs; however, due to the lack of three-dimensional (3D) fabrication techniques that can fabricate such optimal designs in 3D, there have not been many experimental investigations on this challenge. In this study, we benefitted from recent advances in two-photon lithography techniques to fabricate mushroomlike polyurethane elastomer fibers with different aspect ratios of tip to stalk diameter (β) and tip wedge angles (θ) to investigate the effect of these two parameters on the pull-off force. We found similar trends to those predicted theoretically. We found that β has an impact on the slope of the force-displacement curve while both β and θ play a role in the stress distribution and crack propagation. We found that these effects are coupled and the optimal set of parameters also depends on the fiber material. This is the first experimental verification of such optimal designs proposed for mushroomlike microfibers. This experimental approach could be used to evaluate a wide range of complex microstructured adhesive designs suggested in the literature and optimize them.

pi

DOI [BibTex]

DOI [BibTex]


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A thin film active-lens with translational control for dynamically programmable optical zoom

Yun, S., Park, S., Park, B., Nam, S., Park, S. K., Kyung, K.

Applied Physics Letters, 107(8):081907, AIP Publishing, August 2015 (article)

Abstract
We demonstrate a thin film active-lens for rapidly and dynamically controllable optical zoom. The active-lens is composed of a convex hemispherical polydimethylsiloxane (PDMS) lens structure working as an aperture and a dielectric elastomer (DE) membrane actuator, which is a combination of a thin DE layer made with PDMS and a compliant electrode pattern using silver-nanowires. The active-lens is capable of dynamically changing focal point of the soft aperture as high as 18.4% through its translational movement in vertical direction responding to electrically induced bulged-up deformation of the DE membrane actuator. Under operation with various sinusoidal voltage signals, the movement responses are fairly consistent with those estimated from numerical simulation. The responses are not only fast, fairly reversible, and highly durable during continuous cyclic operations, but also large enough to impart dynamic focus tunability for optical zoom in microscopic imaging devices with a light-weight and ultra-slim configuration.

hi

link (url) DOI [BibTex]

link (url) DOI [BibTex]


Thumb xl publications toc
pH-taxis of biohybrid microsystems

Zhuang, J., Carlsen, R. W., Sitti, M.

Scientific reports, 5, Nature Publishing Group, June 2015 (article)

Abstract
The last decade has seen an increasing number of studies developing bacteria and other cell-integrated biohybrid microsystems. However, the highly stochastic motion of these microsystems severely limits their potential use. Here, we present a method that exploits the pH sensing of flagellated bacteria to realize robust drift control of multi-bacteria propelled microrobots. Under three specifically configured pH gradients, we demonstrate that the microrobots exhibit both unidirectional and bidirectional pH-tactic behaviors, which are also observed in free-swimming bacteria. From trajectory analysis, we find that the swimming direction and speed biases are two major factors that contribute to their tactic drift motion. The motion analysis of microrobots also sheds light on the propulsion dynamics of the flagellated bacteria as bioactuators. It is expected that similar driving mechanisms are shared among pH-taxis, chemotaxis, and thermotaxis. By identifying the mechanism that drives the tactic behavior of bacteria-propelled microsystems, this study opens up an avenue towards improving the control of biohybrid microsystems. Furthermore, assuming that it is possible to tune the preferred pH of bioactuators by genetic engineering, these biohybrid microsystems could potentially be applied to sense the pH gradient induced by cancerous cells in stagnant fluids inside human body and realize targeted drug delivery.

pi

DOI Project Page [BibTex]

DOI Project Page [BibTex]


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Structural optimization for flexure-based parallel mechanisms–Towards achieving optimal dynamic and stiffness properties

Lum, G. Z., Teo, T. J., Yeo, S. H., Yang, G., Sitti, M.

Precision Engineering, 42, pages: 195-207, Elsevier, May 2015 (article)

Abstract
Flexure-based parallel mechanisms (FPMs) are a type of compliant mechanisms that consist of a rigid end-effector that is articulated by several parallel, flexible limbs (a.k.a. sub-chains). Existing design methods can enhance the FPMs’ dynamic and stiffness properties by conducting a size optimization on their sub-chains. A similar optimization process, however, was not performed for their sub-chains’ topology, and this may severely limit the benefits of a size optimization. Thus, this paper proposes to use a structural optimization approach to synthesize and optimize the topology, shape and size of the FPMs’ sub-chains. The benefits of this approach are demonstrated via the design and development of a planar X − Y − θz FPM. A prototype of this FPM was evaluated experimentally to have a large workspace of 1.2 mm × 1.2 mm × 6°, a fundamental natural frequency of 102 Hz, and stiffness ratios that are greater than 120. The achieved properties show significant improvement over existing 3-degrees-of-freedom compliant mechanisms that can deflect more than 0.5 mm and 0.5°. These compliant mechanisms typically have stiffness ratios that are less than 60 and a fundamental natural frequency that is less than 45 Hz.

pi

DOI [BibTex]

DOI [BibTex]


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Data-Driven Motion Mappings Improve Transparency in Teleoperation

Khurshid, R. P., Kuchenbecker, K. J.

Presence: Teleoperators and Virtual Environments, 24(2):132-154, May 2015 (article)

hi

[BibTex]

[BibTex]


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Controlled surface topography regulates collective 3D migration by epithelial–mesenchymal composite embryonic tissues

Song, J., Shawky, J. H., Kim, Y., Hazar, M., LeDuc, P. R., Sitti, M., Davidson, L. A.

Biomaterials, 58, pages: 1-9, Elsevier, April 2015 (article)

Abstract
Cells in tissues encounter a range of physical cues as they migrate. Probing single cell and collective migratory responses to physically defined three-dimensional (3D) microenvironments and the factors that modulate those responses are critical to understanding how tissue migration is regulated during development, regeneration, and cancer. One key physical factor that regulates cell migration is topography. Most studies on surface topography and cell mechanics have been carried out with single migratory cells, yet little is known about the spreading and motility response of 3D complex multi-cellular tissues to topographical cues. Here, we examine the response to complex topographical cues of microsurgically isolated tissue explants composed of epithelial and mesenchymal cell layers from naturally 3D organized embryos of the aquatic frog Xenopus laevis. We control topography using fabricated micropost arrays (MPAs) and investigate the collective 3D migration of these multi-cellular systems in these MPAs. We find that the topography regulates both collective and individual cell migration and that dense MPAs reduce but do not eliminate tissue spreading. By modulating cell size through the cell cycle inhibitor Mitomycin C or the spacing of the MPAs we uncover how 3D topographical cues disrupt collective cell migration. We find surface topography can direct both single cell motility and tissue spreading, altering tissue-scale processes that enable efficient conversion of single cell motility into collective movement.

pi

DOI [BibTex]

DOI [BibTex]


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Transfer Printing of Metallic Microstructures on Adhesion-Promoting Hydrogel Substrates

Wu, H., Sariola, V., Zhu, C., Zhao, J., Sitti, M., Bettinger, C. J.

Advanced Materials, 27(22):3398-3404, April 2015 (article)

Abstract
Fabrication schemes that integrate inorganic microstructures with hydrogel substrates are essential for advancing flexible electronics. A transfer printing process that is made possible through the design and synthesis of adhesion-promoting hydrogels as target substrates is reported. This fabrication technique may advance ultracompliant electronics by melding microfabricated structures with swollen hydrogel substrates.

pi

DOI [BibTex]

DOI [BibTex]


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Biomedical applications of untethered mobile milli/microrobots

Sitti, M., Ceylan, H., Hu, W., Giltinan, J., Turan, M., Yim, S., Diller, E.

Proceedings of the IEEE, 103(2):205-224, IEEE, March 2015 (article)

Abstract
Untethered robots miniaturized to the length scale of millimeter and below attract growing attention for the prospect of transforming many aspects of health care and bioengineering. As the robot size goes down to the order of a single cell, previously inaccessible body sites would become available for high-resolution in situ and in vivo manipulations. This unprecedented direct access would enable an extensive range of minimally invasive medical operations. Here, we provide a comprehensive review of the current advances in biomedical untethered mobile milli/microrobots. We put a special emphasis on the potential impacts of biomedical microrobots in the near future. Finally, we discuss the existing challenges and emerging concepts associated with designing such a miniaturized robot for operation inside a biological environment for biomedical applications.

pi

DOI [BibTex]

DOI [BibTex]


Thumb xl publications toc
Collective 3D Migration of Embryonic Epithelial Mesenchymal Composite Tissues are Regulated by Surface Topology

Song, J., Shawky, J., Kim, Y. T., Hazar, M., Sitti, M., LeDuc, P. R., Davidson, L. A.

Biophysical Journal, 108(2):455a, Elsevier, January 2015 (article)

Abstract
Cells in tissues encounter a range of physical cues as they migrate. Probing single cell and collective migratory responses to physically defined three-dimensional (3D) microenvironments and the factors that modulate those responses are critical to understanding how tissue migration is regulated during development, regeneration, and cancer. One key physical factor that regulates cell migration is topology. Most studies on surface topology and cell mechanics have been carried out with single migratory cells, yet little is known about the spreading and motility response of 3D complex multicellular tissues to topological cues. Here, we examine the behaviors of microsurgically isolated tissue explants composed of epithelial and mesenchymal cell layers from naturally 3D organized embryos of the aquatic frog Xenopus laevis to complex topological cues. We control topology using fabricated micropost arrays (MPAs) with different diameters (e.g., different spacing gaps) and investigate the collective 3D migration of these multicellular systems in these MPAs. Our topographical controlled approach for cellular application enables us to achieve a high degree of control over micropost positioning and geometry via simple, accurate, and repeatable microfabrication processes. We find that the topology regulates both collective and individual cell migration and that dense MPAs reduce but do not eliminate tissue spreading. By modulating cell size through the cell cycle inhibitor Mitomycin C or the spacing within MPAs we discover a role for topology in disrupting collective enhancement of cell migration. We find 3D topological cues can direct both single cell motility and tissue spreading, altering tissue-scale processes that enable efficient conversion of single cell motility into collective movement.

pi

DOI [BibTex]

DOI [BibTex]


Thumb xl publications toc
Three-dimensional heterogeneous assembly of coded microgels using an untethered mobile microgripper

Chung, S. E., Dong, X., Sitti, M.

Lab on a Chip, 15(7):1667-1676, Royal Society of Chemistry, January 2015 (article)

Abstract
Three-dimensional (3D) heterogeneous assembly of coded microgels in enclosed aquatic environments is demonstrated using a remotely actuated and controlled magnetic microgripper by a customized electromagnetic coil system. The microgripper uses different ‘stick–slip’ and ‘rolling’ locomotion in 2D and also levitation in 3D by magnetic gradient-based pulling force. This enables the microrobot to precisely manipulate each microgel by controlling its position and orientation in all x–y–z directions. Our microrobotic assembly method broke the barrier of limitation on the number of assembled microgel layers, because it enabled precise 3D levitation of the microgripper. We used the gripper to assemble microgels that had been coded with different colours and shapes onto prefabricated polymeric microposts. This eliminates the need for extra secondary cross-linking to fix the final construct. We demonstrated assembly of microgels on a single micropost up to ten layers. By increasing the number and changing the distribution of the posts, complex heterogeneous microsystems were possible to construct in 3D.

pi

DOI Project Page [BibTex]

DOI Project Page [BibTex]


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Robotic Learning of Haptic Adjectives Through Physical Interaction

Chu, V., McMahon, I., Riano, L., McDonald, C. G., He, Q., Perez-Tejada, J. M., Arrigo, M., Darrell, T., Kuchenbecker, K. J.

Robotics and Autonomous Systems, 63(3):279-292, 2015, Vivian Chu, Ian MacMahon, and Lorenzo Riano contributed equally to this publication. Corrigendum published in June 2016 (article)

hi

[BibTex]

[BibTex]


Thumb xl publications toc
Integrating mechanism synthesis and topological optimization technique for stiffness-oriented design of a three degrees-of-freedom flexure-based parallel mechanism

Lum, G. Z., Teo, T. J., Yang, G., Yeo, S. H., Sitti, M.

Precision Engineering, 39, pages: 125-133, Elsevier, January 2015 (article)

Abstract
This paper introduces a new design approach to synthesize multiple degrees-of-freedom (DOF) flexure-based parallel mechanism (FPM). Termed as an integrated design approach, it is a systematic design methodology, which integrates both classical mechanism synthesis and modern topology optimization technique, to deliver an optimized multi-DOF FPM. This design approach is separated into two levels. At sub-chain level, a novel topology optimization technique, which uses the classical linkage mechanisms as DNA seeds, is used to synthesize the compliant joints or limbs. At configuration level, the optimal compliant joints are used to form the parallel limbs of the multi-DOF FPM and another stage of optimization was conducted to determine the optimal space distribution between these compliant joints so as to generate a multi-DOF FPM with optimized stiffness characteristic. In this paper, the design of a 3-DOF planar motion FPM was used to demonstrate the effectiveness and accuracy of this proposed design approach.

pi

DOI [BibTex]


Thumb xl publications toc
Actively controlled fibrillar friction surfaces

Marvi, H, Han, Y, Sitti, M

Applied Physics Letters, 106(5):051602, AIP Publishing, January 2015 (article)

Abstract
In this letter, we propose a technique by which we can actively adjust frictional properties of elastic fibrillar structures in different directions. Using a mesh attached to a two degree-of-freedom linear stage, we controlled the active length and the tilt angle of fibers, independently. Thus, we were able to achieve desired levels of friction forces in different directions and significantly improve passive friction anisotropies observed in the same fiber arrays. The proposed technique would allow us to readily control the friction anisotropy and the friction magnitude of fibrillar structures in any planar direction.

pi

DOI [BibTex]

DOI [BibTex]


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Effects of Vibrotactile Feedback on Human Motor Learning of Arbitrary Arm Motions

Bark, K., Hyman, E., Tan, F., Cha, E., Jax, S. A., Buxbaum, L. J., Kuchenbecker, K. J.

IEEE Transactions on Neural Systems and Rehabilitation Engineering, 23(1):51-63, January 2015 (article)

hi

[BibTex]

[BibTex]


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Exciting Engineered Passive Dynamics in a Bipedal Robot

Renjewski, D., Spröwitz, A., Peekema, A., Jones, M., Hurst, J.

{IEEE Transactions on Robotics and Automation}, 31(5):1244-1251, IEEE, New York, NY, 2015 (article)

Abstract
A common approach in designing legged robots is to build fully actuated machines and control the machine dynamics entirely in soft- ware, carefully avoiding impacts and expending a lot of energy. However, these machines are outperformed by their human and animal counterparts. Animals achieve their impressive agility, efficiency, and robustness through a close integration of passive dynamics, implemented through mechanical components, and neural control. Robots can benefit from this same integrated approach, but a strong theoretical framework is required to design the passive dynamics of a machine and exploit them for control. For this framework, we use a bipedal spring–mass model, which has been shown to approximate the dynamics of human locomotion. This paper reports the first implementation of spring–mass walking on a bipedal robot. We present the use of template dynamics as a control objective exploiting the engineered passive spring–mass dynamics of the ATRIAS robot. The results highlight the benefits of combining passive dynamics with dynamics-based control and open up a library of spring–mass model-based control strategies for dynamic gait control of robots.

dlg

link (url) DOI Project Page [BibTex]

link (url) DOI Project Page [BibTex]


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Kinematic and gait similarities between crawling human infants and other quadruped mammals

Righetti, L., Nylen, A., Rosander, K., Ijspeert, A.

Frontiers in Neurology, 6(17), February 2015 (article)

Abstract
Crawling on hands and knees is an early pattern of human infant locomotion, which offers an interesting way of studying quadrupedalism in one of its simplest form. We investigate how crawling human infants compare to other quadruped mammals, especially primates. We present quantitative data on both the gait and kinematics of seven 10-month-old crawling infants. Body movements were measured with an optoelectronic system giving precise data on 3-dimensional limb movements. Crawling on hands and knees is very similar to the locomotion of non-human primates in terms of the quite protracted arm at touch-down, the coordination between the spine movements in the lateral plane and the limbs, the relatively extended limbs during locomotion and the strong correlation between stance duration and speed of locomotion. However, there are important differences compared to primates, such as the choice of a lateral-sequence walking gait, which is similar to most non-primate mammals and the relatively stiff elbows during stance as opposed to the quite compliant gaits of primates. These finding raise the question of the role of both the mechanical structure of the body and neural control on the determination of these characteristics.

mg

link (url) DOI [BibTex]

link (url) DOI [BibTex]


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Efficient single-cell poration by microsecond laser pulses

Fan, Q., Hu, W., Ohta, A. T.

Lab on a Chip, 15(2):581-588, Royal Society of Chemistry, 2015 (article)

pi

[BibTex]

[BibTex]

2012


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Evaluation of Tactile Feedback Methods for Wrist Rotation Guidance

Stanley, A. A., Kuchenbecker, K. J.

IEEE Transactions on Haptics, 5(3):240-251, July 2012 (article)

hi

[BibTex]

2012


[BibTex]