Publications | Max Planck Institute for Intelligent Systems

33 results (View BibTeX file of all listed publications)

2018

Role of symmetry in driven propulsion at low Reynolds number

Sachs, J., Morozov, K. I., Kenneth, O., Qiu, T., Segreto, N., Fischer, P., Leshansky, A. M.

Phys. Rev. E, 98(6):063105, American Physical Society, December 2018 (article)

Abstract

We theoretically and experimentally investigate low-Reynolds-number propulsion of geometrically achiral planar objects that possess a dipole moment and that are driven by a rotating magnetic field. Symmetry considerations (involving parity, $\widehat{P}$, and charge conjugation, $\widehat{C}$) establish correspondence between propulsive states depending on orientation of the dipolar moment. Although basic symmetry arguments do not forbid individual symmetric objects to efficiently propel due to spontaneous symmetry breaking, they suggest that the average ensemble velocity vanishes. Some additional arguments show, however, that highly symmetrical ($\widehat{P}$-even) objects exhibit no net propulsion while individual less symmetrical ($\widehat{C}\widehat{P}$-even) propellers do propel. Particular magnetization orientation, rendering the shape $\widehat{C}\widehat{P}$-odd, yields unidirectional motion typically associated with chiral structures, such as helices. If instead of a structure with a permanent dipole we consider a polarizable object, some of the arguments have to be modified. For instance, we demonstrate a truly achiral ($\widehat{P}$- and $\widehat{C}\widehat{P}$-even) planar shape with an induced electric dipole that can propel by electro-rotation. We thereby show that chirality is not essential for propulsion due to rotation-translation coupling at low Reynolds number.

link (url) DOI Project Page [BibTex]

2018

pf Sachs, J., Morozov, K. I., Kenneth, O., Qiu, T., Segreto, N., Fischer, P., Leshansky, A. M. Role of symmetry in driven propulsion at low Reynolds number Phys. Rev. E, 98(6):063105, American Physical Society, December 2018 (article)

link (url) DOI Project Page [BibTex]

Optical and Thermophoretic Control of Janus Nanopen Injection into Living Cells

Maier, C. M., Huergo, M. A., Milosevic, S., Pernpeintner, C., Li, M., Singh, D. P., Walker, D., Fischer, P., Feldmann, J., Lohmüller, T.

Nano Letters, 18, pages: 7935–7941, November 2018 (article) Accepted

Abstract

Devising strategies for the controlled injection of functional nanoparticles and reagents into living cells paves the way for novel applications in nanosurgery, sensing, and drug delivery. Here, we demonstrate the light-controlled guiding and injection of plasmonic Janus nanopens into living cells. The pens are made of a gold nanoparticle attached to a dielectric alumina shaft. Balancing optical and thermophoretic forces in an optical tweezer allows single Janus nanopens to be trapped and positioned on the surface of living cells. While the optical injection process involves strong heating of the plasmonic side, the temperature of the alumina stays significantly lower, thus allowing the functionalization with fluorescently labeled, single-stranded DNA and, hence, the spatially controlled injection of genetic material with an untethered nanocarrier.

link (url) DOI [BibTex]

pf Maier, C. M., Huergo, M. A., Milosevic, S., Pernpeintner, C., Li, M., Singh, D. P., Walker, D., Fischer, P., Feldmann, J., Lohmüller, T. Optical and Thermophoretic Control of Janus Nanopen Injection into Living Cells Nano Letters, 18, pages: 7935–7941, November 2018 (article) Accepted

link (url) DOI [BibTex]

A swarm of slippery micropropellers penetrates the vitreous body of the eye

Wu, Z., Troll, J., Jeong, H. H., Wei, Q., Stang, M., Ziemssen, F., Wang, Z., Dong, M., Schnichels, S., Qiu, T., Fischer, P.

Science Advances, 4(11):eaat4388, November 2018 (article)

Abstract

The intravitreal delivery of therapeutic agents promises major benefits in the field of ocular medicine. Traditional delivery methods rely on the random, passive diffusion of molecules, which do not allow for the rapid delivery of a concentrated cargo to a defined region at the posterior pole of the eye. The use of particles promises targeted delivery but faces the challenge that most tissues including the vitreous have a tight macromolecular matrix that acts as a barrier and prevents its penetration. Here, we demonstrate novel intravitreal delivery microvehicles slippery micropropellers that can be actively propelled through the vitreous humor to reach the retina. The propulsion is achieved by helical magnetic micropropellers that have a liquid layer coating to minimize adhesion to the surrounding biopolymeric network. The submicrometer diameter of the propellers enables the penetration of the biopolymeric network and the propulsion through the porcine vitreous body of the eye over centimeter distances. Clinical optical coherence tomography is used to monitor the movement of the propellers and confirm their arrival on the retina near the optic disc. Overcoming the adhesion forces and actively navigating a swarm of micropropellers in the dense vitreous humor promise practical applications in ophthalmology.

Video: Nanorobots propel through the eye link (url) DOI [BibTex]

pf Wu, Z., Troll, J., Jeong, H. H., Wei, Q., Stang, M., Ziemssen, F., Wang, Z., Dong, M., Schnichels, S., Qiu, T., Fischer, P. A swarm of slippery micropropellers penetrates the vitreous body of the eye Science Advances, 4(11):eaat4388, November 2018 (article)

Video: Nanorobots propel through the eye link (url) DOI [BibTex]

A Value-Driven Eldercare Robot: Virtual and Physical Instantiations of a Case-Supported Principle-Based Behavior Paradigm

Anderson, M., Anderson, S., Berenz, V.

Proceedings of the IEEE, pages: 1,15, October 2018 (article)

Abstract

In this paper, a case-supported principle-based behavior paradigm is proposed to help ensure ethical behavior of autonomous machines. We argue that ethically significant behavior of autonomous systems should be guided by explicit ethical principles determined through a consensus of ethicists. Such a consensus is likely to emerge in many areas in which autonomous systems are apt to be deployed and for the actions they are liable to undertake. We believe that this is the case since we are more likely to agree on how machines ought to treat us than on how human beings ought to treat one another. Given such a consensus, particular cases of ethical dilemmas where ethicists agree on the ethically relevant features and the right course of action can be used to help discover principles that balance these features when they are in conflict. Such principles not only help ensure ethical behavior of complex and dynamic systems but also can serve as a basis for justification of this behavior. The requirements, methods, implementation, and evaluation components of the paradigm are detailed as well as its instantiation in both a simulated and real robot functioning in the domain of eldercare.

link (url) DOI [BibTex]

am Anderson, M., Anderson, S., Berenz, V. A Value-Driven Eldercare Robot: Virtual and Physical Instantiations of a Case-Supported Principle-Based Behavior Paradigm Proceedings of the IEEE, pages: 1,15, October 2018 (article)

link (url) DOI [BibTex]

Softness, Warmth, and Responsiveness Improve Robot Hugs

Block, A. E., Kuchenbecker, K. J.

International Journal of Social Robotics, 11(1):49-64, October 2018 (article)

Abstract

Hugs are one of the first forms of contact and affection humans experience. Due to their prevalence and health benefits, roboticists are naturally interested in having robots one day hug humans as seamlessly as humans hug other humans. This project's purpose is to evaluate human responses to different robot physical characteristics and hugging behaviors. Specifically, we aim to test the hypothesis that a soft, warm, touch-sensitive PR2 humanoid robot can provide humans with satisfying hugs by matching both their hugging pressure and their hugging duration. Thirty relatively young and rather technical participants experienced and evaluated twelve hugs with the robot, divided into three randomly ordered trials that focused on physical robot characteristics (single factor, three levels) and nine randomly ordered trials with low, medium, and high hug pressure and duration (two factors, three levels each). Analysis of the results showed that people significantly prefer soft, warm hugs over hard, cold hugs. Furthermore, users prefer hugs that physically squeeze them and release immediately when they are ready for the hug to end. Taking part in the experiment also significantly increased positive user opinions of robots and robot use.

link (url) DOI Project Page [BibTex]

hi Block, A. E., Kuchenbecker, K. J. Softness, Warmth, and Responsiveness Improve Robot Hugs International Journal of Social Robotics, 11(1):49-64, October 2018 (article)

link (url) DOI Project Page [BibTex]

Fast spatial scanning of 3D ultrasound fields via thermography

Melde, K., Qiu, T., Fischer, P.

Applied Physics Letters, 113(13):133503, September 2018 (article)

Abstract

We propose and demonstrate a thermographic method that allows rapid scanning of ultrasound fields in a volume to yield 3D maps of the sound intensity. A thin sound-absorbing membrane is continuously translated through a volume of interest while a thermal camera records the evolution of its surface temperature. The temperature rise is a function of the absorbed sound intensity, such that the thermal image sequence can be combined to reveal the sound intensity distribution in the traversed volume. We demonstrate the mapping of ultrasound fields, which is several orders of magnitude faster than scanning with a hydrophone. Our results are in very good agreement with theoretical simulations.

link (url) DOI Project Page [BibTex]

pf Melde, K., Qiu, T., Fischer, P. Fast spatial scanning of 3D ultrasound fields via thermography Applied Physics Letters, 113(13):133503, September 2018 (article)

link (url) DOI Project Page [BibTex]

Playful: Reactive Programming for Orchestrating Robotic Behavior

Berenz, V., Schaal, S.

IEEE Robotics Automation Magazine, 25(3):49-60, September 2018 (article) In press

Abstract

For many service robots, reactivity to changes in their surroundings is a must. However, developing software suitable for dynamic environments is difficult. Existing robotic middleware allows engineers to design behavior graphs by organizing communication between components. But because these graphs are structurally inflexible, they hardly support the development of complex reactive behavior. To address this limitation, we propose Playful, a software platform that applies reactive programming to the specification of robotic behavior.

playful website playful_IEEE_RAM link (url) DOI [BibTex]

am Berenz, V., Schaal, S. Playful: Reactive Programming for Orchestrating Robotic Behavior IEEE Robotics Automation Magazine, 25(3):49-60, September 2018 (article) In press

playful website playful_IEEE_RAM link (url) DOI [BibTex]

ClusterNet: Instance Segmentation in RGB-D Images

Shao, L., Tian, Y., Bohg, J.

arXiv, September 2018, Submitted to ICRA'19 (article) Submitted

Abstract

We propose a method for instance-level segmentation that uses RGB-D data as input and provides detailed information about the location, geometry and number of {\em individual\/} objects in the scene. This level of understanding is fundamental for autonomous robots. It enables safe and robust decision-making under the large uncertainty of the real-world. In our model, we propose to use the first and second order moments of the object occupancy function to represent an object instance. We train an hourglass Deep Neural Network (DNN) where each pixel in the output votes for the 3D position of the corresponding object center and for the object's size and pose. The final instance segmentation is achieved through clustering in the space of moments. The object-centric training loss is defined on the output of the clustering. Our method outperforms the state-of-the-art instance segmentation method on our synthesized dataset. We show that our method generalizes well on real-world data achieving visually better segmentation results.

link (url) [BibTex]

am Shao, L., Tian, Y., Bohg, J. ClusterNet: Instance Segmentation in RGB-D Images arXiv, September 2018, Submitted to ICRA'19 (article) Submitted

link (url) [BibTex]

Leveraging Contact Forces for Learning to Grasp

Merzic, H., Bogdanovic, M., Kappler, D., Righetti, L., Bohg, J.

arXiv, September 2018, Submitted to ICRA'19 (article) Submitted

Abstract

Grasping objects under uncertainty remains an open problem in robotics research. This uncertainty is often due to noisy or partial observations of the object pose or shape. To enable a robot to react appropriately to unforeseen effects, it is crucial that it continuously takes sensor feedback into account. While visual feedback is important for inferring a grasp pose and reaching for an object, contact feedback offers valuable information during manipulation and grasp acquisition. In this paper, we use model-free deep reinforcement learning to synthesize control policies that exploit contact sensing to generate robust grasping under uncertainty. We demonstrate our approach on a multi-fingered hand that exhibits more complex finger coordination than the commonly used two- fingered grippers. We conduct extensive experiments in order to assess the performance of the learned policies, with and without contact sensing. While it is possible to learn grasping policies without contact sensing, our results suggest that contact feedback allows for a significant improvement of grasping robustness under object pose uncertainty and for objects with a complex shape.

am mg

video arXiv [BibTex]

am mg Merzic, H., Bogdanovic, M., Kappler, D., Righetti, L., Bohg, J. Leveraging Contact Forces for Learning to Grasp arXiv, September 2018, Submitted to ICRA'19 (article) Submitted

video arXiv [BibTex]

Diffusion Measurements of Swimming Enzymes with Fluorescence Correlation Spectroscopy

Günther, J., Börsch, M., Fischer, P.

Accounts of Chemical Research, 51(9):1911-1920, August 2018 (article)

Abstract

Self-propelled chemical motors are chemically powered micro- or nanosized swimmers. The energy required for these motors’ active motion derives from catalytic chemical reactions and the transformation of a fuel dissolved in the solution. While self-propulsion is now well established for larger particles, it is still unclear if enzymes, nature’s nanometer-sized catalysts, are potentially also self-powered nanomotors. Because of its small size, any increase in an enzyme’s diffusion due to active self-propulsion must be observed on top of the enzyme’s passive Brownian motion, which dominates at this scale. Fluorescence correlation spectroscopy (FCS) is a sensitive method to quantify the diffusion properties of single fluorescently labeled molecules in solution. FCS experiments have shown a general increase in the diffusion constant of a number of enzymes when the enzyme is catalytically active. Diffusion enhancements after addition of the enzyme’s substrate (and sometimes its inhibitor) of up to 80\% have been reported, which is at least 1 order of magnitude higher than what theory would predict. However, many factors contribute to the FCS signal and in particular the shape of the autocorrelation function, which underlies diffusion measurements by fluorescence correlation spectroscopy. These effects need to be considered to establish if and by how much the catalytic activity changes an enzyme’s diffusion.We carefully review phenomena that can play a role in FCS experiments and the determination of enzyme diffusion, including the dissociation of enzyme oligomers upon interaction with the substrate, surface binding of the enzyme to glass during the experiment, conformational changes upon binding, and quenching of the fluorophore. We show that these effects can cause changes in the FCS signal that behave similar to an increase in diffusion. However, in the case of the enzymes F1-ATPase and alkaline phosphatase, we demonstrate that there is no measurable increase in enzyme diffusion. Rather, dissociation and conformational changes account for the changes in the FCS signal in the former and fluorophore quenching in the latter. Within the experimental accuracy of our FCS measurements, we do not observe any change in diffusion due to activity for the enzymes we have investigated.We suggest useful control experiments and additional tests for future FCS experiments that should help establish if the observed diffusion enhancement is real or if it is due to an experimental or data analysis artifact. We show that fluorescence lifetime and mean intensity measurements are essential in order to identify the nature of the observed changes in the autocorrelation function. While it is clear from theory that chemically active enzymes should also act as self-propelled nanomotors, our FCS measurements show that the associated increase in diffusion is much smaller than previously reported. Further experiments are needed to quantify the contribution of the enzymes’ catalytic activity to their self-propulsion. We hope that our findings help to establish a useful protocol for future FCS studies in this field and help establish by how much the diffusion of an enzyme is enhanced through catalytic activity.

link (url) DOI [BibTex]

pf Günther, J., Börsch, M., Fischer, P. Diffusion Measurements of Swimming Enzymes with Fluorescence Correlation Spectroscopy Accounts of Chemical Research, 51(9):1911-1920, August 2018 (article)

link (url) DOI [BibTex]

Uphill production of dihydrogen by enzymatic oxidation of glucose without an external energy source

Suraniti, E., Merzeau, P., Roche, J., Gounel, S., Mark, A. G., Fischer, P., Mano, N., Kuhn, A.

Nature Communications, 9(1):3229, August 2018 (article)

Abstract

Chemical systems do not allow the coupling of energy from several simple reactions to drive a subsequent reaction, which takes place in the same medium and leads to a product with a higher energy than the one released during the first reaction. Gibbs energy considerations thus are not favorable to drive e.g., water splitting by the direct oxidation of glucose as a model reaction. Here, we show that it is nevertheless possible to carry out such an energetically uphill reaction, if the electrons released in the oxidation reaction are temporarily stored in an electromagnetic system, which is then used to raise the electrons' potential energy so that they can power the electrolysis of water in a second step. We thereby demonstrate the general concept that lower energy delivering chemical reactions can be used to enable the formation of higher energy consuming reaction products in a closed system.

link (url) DOI [BibTex]

pf Suraniti, E., Merzeau, P., Roche, J., Gounel, S., Mark, A. G., Fischer, P., Mano, N., Kuhn, A. Uphill production of dihydrogen by enzymatic oxidation of glucose without an external energy source Nature Communications, 9(1):3229, August 2018 (article)

link (url) DOI [BibTex]

Chemical micromotors self-assemble and self-propel by spontaneous symmetry breaking

Yu, T., Chuphal, P., Thakur, S., Reigh, S. Y., Singh, D. P., Fischer, P.

Chem. Comm., 54, pages: 11933-11936, August 2018 (article)

Abstract

Self-propelling chemical motors have thus far required the fabrication of Janus particles with an asymmetric catalyst distribution. Here, we demonstrate that simple, isotropic colloids can spontaneously assemble to yield dimer motors that self-propel. In a mixture of isotropic titanium dioxide colloids with photo-chemical catalytic activity and passive silica colloids, light illumination causes diffusiophoretic attractions between the active and passive particles and leads to the formation of dimers. The dimers constitute a symmetry-broken motor, whose dynamics can be fully controlled by the illumination conditions. Computer simulations reproduce the dynamics of the colloids and are in good agreement with experiments. The current work presents a simple route to obtain large numbers of self-propelling chemical motors from a dispersion of spherically symmetric colloids through spontaneous symmetry breaking.

link (url) DOI [BibTex]

pf Yu, T., Chuphal, P., Thakur, S., Reigh, S. Y., Singh, D. P., Fischer, P. Chemical micromotors self-assemble and self-propel by spontaneous symmetry breaking Chem. Comm., 54, pages: 11933-11936, August 2018 (article)

link (url) DOI [BibTex]

Chemotaxis of Active Janus Nanoparticles

Popescu, M. N., Uspal, W. E., Bechinger, C., Fischer, P.

Nano Letters, 18(9):5345–5349, July 2018 (article)

Abstract

While colloids and molecules in solution exhibit passive Brownian motion, particles that are partially covered with a catalyst, which promotes the transformation of a fuel dissolved in the solution, can actively move. These active Janus particles are known as “chemical nanomotors” or self-propelling “swimmers” and have been realized with a range of catalysts, sizes, and particle geometries. Because their active translation depends on the fuel concentration, one expects that active colloidal particles should also be able to swim toward a fuel source. Synthesizing and engineering nanoparticles with distinct chemotactic properties may enable important developments, such as particles that can autonomously swim along a pH gradient toward a tumor. Chemotaxis requires that the particles possess an active coupling of their orientation to a chemical gradient. In this Perspective we provide a simple, intuitive description of the underlying mechanisms for chemotaxis, as well as the means to analyze and classify active particles that can show positive or negative chemotaxis. The classification provides guidance for engineering a specific response and is a useful organizing framework for the quantitative analysis and modeling of chemotactic behaviors. Chemotaxis is emerging as an important focus area in the field of active colloids and promises a number of fascinating applications for nanoparticles and particle-based delivery.

link (url) DOI [BibTex]

pf Popescu, M. N., Uspal, W. E., Bechinger, C., Fischer, P. Chemotaxis of Active Janus Nanoparticles Nano Letters, 18(9):5345–5349, July 2018 (article)

link (url) DOI [BibTex]

Task-Driven PCA-Based Design Optimization of Wearable Cutaneous Devices

Pacchierotti, C., Young, E. M., Kuchenbecker, K. J.

IEEE Robotics and Automation Letters, 3(3):2214-2221, July 2018, Presented at ICRA 2018 (article)

Abstract

Small size and low weight are critical requirements for wearable and portable haptic interfaces, making it essential to work toward the optimization of their sensing and actuation systems. This paper presents a new approach for task-driven design optimization of fingertip cutaneous haptic devices. Given one (or more) target tactile interactions to render and a cutaneous device to optimize, we evaluate the minimum number and best configuration of the device’s actuators to minimize the estimated haptic rendering error. First, we calculate the motion needed for the original cutaneous device to render the considered target interaction. Then, we run a principal component analysis (PCA) to search for possible couplings between the original motor inputs, looking also for the best way to reconfigure them. If some couplings exist, we can re-design our cutaneous device with fewer motors, optimally configured to render the target tactile sensation. The proposed approach is quite general and can be applied to different tactile sensors and cutaneous devices. We validated it using a BioTac tactile sensor and custom plate-based 3-DoF and 6-DoF fingertip cutaneous devices, considering six representative target tactile interactions. The algorithm was able to find couplings between each device’s motor inputs, proving it to be a viable approach to optimize the design of wearable and portable cutaneous devices. Finally, we present two examples of optimized designs for our 3-DoF fingertip cutaneous device.

link (url) DOI [BibTex]

hi Pacchierotti, C., Young, E. M., Kuchenbecker, K. J. Task-Driven PCA-Based Design Optimization of Wearable Cutaneous Devices IEEE Robotics and Automation Letters, 3(3):2214-2221, July 2018, Presented at ICRA 2018 (article)

link (url) DOI [BibTex]

Teaching a Robot Bimanual Hand-Clapping Games via Wrist-Worn IMUs

Fitter, N. T., Kuchenbecker, K. J.

Frontiers in Robotics and Artificial Intelligence, 5(85), July 2018 (article)

Abstract

Colleagues often shake hands in greeting, friends connect through high fives, and children around the world rejoice in hand-clapping games. As robots become more common in everyday human life, they will have the opportunity to join in these social-physical interactions, but few current robots are intended to touch people in friendly ways. This article describes how we enabled a Baxter Research Robot to both teach and learn bimanual hand-clapping games with a human partner. Our system monitors the user's motions via a pair of inertial measurement units (IMUs) worn on the wrists. We recorded a labeled library of 10 common hand-clapping movements from 10 participants; this dataset was used to train an SVM classifier to automatically identify hand-clapping motions from previously unseen participants with a test-set classification accuracy of 97.0%. Baxter uses these sensors and this classifier to quickly identify the motions of its human gameplay partner, so that it can join in hand-clapping games. This system was evaluated by N = 24 naïve users in an experiment that involved learning sequences of eight motions from Baxter, teaching Baxter eight-motion game patterns, and completing a free interaction period. The motion classification accuracy in this less structured setting was 85.9%, primarily due to unexpected variations in motion timing. The quantitative task performance results and qualitative participant survey responses showed that learning games from Baxter was significantly easier than teaching games to Baxter, and that the teaching role caused users to consider more teamwork aspects of the gameplay. Over the course of the experiment, people felt more understood by Baxter and became more willing to follow the example of the robot. Users felt uniformly safe interacting with Baxter, and they expressed positive opinions of Baxter and reported fun interacting with the robot. Taken together, the results indicate that this robot achieved credible social-physical interaction with humans and that its ability to both lead and follow systematically changed the human partner's experience.

DOI [BibTex]

hi Fitter, N. T., Kuchenbecker, K. J. Teaching a Robot Bimanual Hand-Clapping Games via Wrist-Worn IMUs Frontiers in Robotics and Artificial Intelligence, 5(85), July 2018 (article)

DOI [BibTex]

Real-time Perception meets Reactive Motion Generation

(Best Systems Paper Finalists - Amazon Robotics Best Paper Awards in Manipulation)

Kappler, D., Meier, F., Issac, J., Mainprice, J., Garcia Cifuentes, C., Wüthrich, M., Berenz, V., Schaal, S., Ratliff, N., Bohg, J.

IEEE Robotics and Automation Letters, 3(3):1864-1871, July 2018 (article)

Abstract

We address the challenging problem of robotic grasping and manipulation in the presence of uncertainty. This uncertainty is due to noisy sensing, inaccurate models and hard-to-predict environment dynamics. Our approach emphasizes the importance of continuous, real-time perception and its tight integration with reactive motion generation methods. We present a fully integrated system where real-time object and robot tracking as well as ambient world modeling provides the necessary input to feedback controllers and continuous motion optimizers. Specifically, they provide attractive and repulsive potentials based on which the controllers and motion optimizer can online compute movement policies at different time intervals. We extensively evaluate the proposed system on a real robotic platform in four scenarios that exhibit either challenging workspace geometry or a dynamic environment. We compare the proposed integrated system with a more traditional sense-plan-act approach that is still widely used. In 333 experiments, we show the robustness and accuracy of the proposed system.

arxiv video video link (url) DOI Project Page [BibTex]

am Kappler, D., Meier, F., Issac, J., Mainprice, J., Garcia Cifuentes, C., Wüthrich, M., Berenz, V., Schaal, S., Ratliff, N., Bohg, J. Real-time Perception meets Reactive Motion Generation IEEE Robotics and Automation Letters, 3(3):1864-1871, July 2018 (article)

arxiv video video link (url) DOI Project Page [BibTex]

Bioinspired microrobots

Palagi, S., Fischer, P.

Nature Reviews Materials, 3, pages: 113–124, May 2018 (article)

Abstract

Microorganisms can move in complex media, respond to the environment and self-organize. The field of microrobotics strives to achieve these functions in mobile robotic systems of sub-millimetre size. However, miniaturization of traditional robots and their control systems to the microscale is not a viable approach. A promising alternative strategy in developing microrobots is to implement sensing, actuation and control directly in the materials, thereby mimicking biological matter. In this Review, we discuss design principles and materials for the implementation of robotic functionalities in microrobots. We examine different biological locomotion strategies, and we discuss how they can be artificially recreated in magnetic microrobots and how soft materials improve control and performance. We show that smart, stimuli-responsive materials can act as on-board sensors and actuators and that ‘active matter’ enables autonomous motion, navigation and collective behaviours. Finally, we provide a critical outlook for the field of microrobotics and highlight the challenges that need to be overcome to realize sophisticated microrobots, which one day might rival biological machines.

link (url) DOI [BibTex]

pf Palagi, S., Fischer, P. Bioinspired microrobots Nature Reviews Materials, 3, pages: 113–124, May 2018 (article)

link (url) DOI [BibTex]

Graphene-silver hybrid devices for sensitive photodetection in the ultraviolet

Paria, D., Jeong, H. H., Vadakkumbatt, V., Deshpande, P., Fischer, P., Ghosh, A., Ghosh, A.

Nanoscale, 10, pages: 7685-7693, April 2018 (article)

Abstract

The weak light-matter interaction in graphene can be enhanced with a number of strategies, among which sensitization with plasmonic nanostructures is particularly attractive. This has resulted in the development of graphene-plasmonic hybrid systems with strongly enhanced photodetection efficiencies in the visible and the IR, but none in the UV. Here, we describe a silver nanoparticle-graphene stacked optoelectronic device that shows strong enhancement of its photoresponse across the entire UV spectrum. The device fabrication strategy is scalable and modular. Self-assembly techniques are combined with physical shadow growth techniques to fabricate a regular large-area array of 50 nm silver nanoparticles onto which CVD graphene is transferred. The presence of the silver nanoparticles resulted in a plasmonically enhanced photoresponse as high as 3.2 A W-1 in the wavelength range from 330 nm to 450 nm. At lower wavelengths, close to the Van Hove singularity of the density of states in graphene, we measured an even higher responsivity of 14.5 A W-1 at 280 nm, which corresponds to a more than 10 000-fold enhancement over the photoresponse of native graphene.

link (url) DOI [BibTex]

pf Paria, D., Jeong, H. H., Vadakkumbatt, V., Deshpande, P., Fischer, P., Ghosh, A., Ghosh, A. Graphene-silver hybrid devices for sensitive photodetection in the ultraviolet Nanoscale, 10, pages: 7685-7693, April 2018 (article)

link (url) DOI [BibTex]

Nanoparticles on the move for medicine

Fischer, P.

Physics World Focus on Nanotechnology, pages: 26028, (Editors: Margaret Harris), IOP Publishing Ltd and individual contributors, April 2018 (article)

Abstract

Peer Fischer outlines the prospects for creating “nanoswimmers” that can be steered through the body to deliver drugs directly to their targets Molecules don’t move very fast on their own. If they had to rely solely on diffusion – a slow and inefficient process linked to the Brownian motion of small particles and molecules in solution – then a protein molecule, for instance, would take around three weeks to travel a single centimetre down a nerve fibre. This is why active transport mechanisms exist in cells and in the human body: without them, all the processes of life would happen at a pace that would make snails look speedy.

link (url) [BibTex]

pf Fischer, P. Nanoparticles on the move for medicine Physics World Focus on Nanotechnology, pages: 26028, (Editors: Margaret Harris), IOP Publishing Ltd and individual contributors, April 2018 (article)

link (url) [BibTex]

Automatically Rating Trainee Skill at a Pediatric Laparoscopic Suturing Task

Oquendo, Y. A., Riddle, E. W., Hiller, D., Blinman, T. A., Kuchenbecker, K. J.

Surgical Endoscopy, 32(4):1840-1857, April 2018 (article)

DOI [BibTex]

hi Oquendo, Y. A., Riddle, E. W., Hiller, D., Blinman, T. A., Kuchenbecker, K. J. Automatically Rating Trainee Skill at a Pediatric Laparoscopic Suturing Task Surgical Endoscopy, 32(4):1840-1857, April 2018 (article)

DOI [BibTex]

Photogravitactic Microswimmers

Singh, D. P., Uspal, W. E., Popescu, M. N., Wilson, L. G., Fischer, P.

Adv. Func. Mat., 28, pages: 1706660, Febuary 2018 (article)

Abstract

Abstract Phototactic microorganisms are commonly observed to respond to natural sunlight by swimming upward against gravity. This study demonstrates that synthetic photochemically active microswimmers can also swim against gravity. The particles initially sediment and, when illuminated at low light intensities exhibit wall‐bound states of motion near the bottom surface. Upon increasing the intensity of light, the artificial swimmers lift off from the wall and swim against gravity and away from the light source. This motion in the bulk has been further confirmed using holographic microscopy. A theoretical model is presented within the framework of self‐diffusiophoresis, which allows to unequivocally identify the photochemical activity and the phototactic response as key mechanisms in the observed phenomenology. Since the lift‐off threshold intensity depends on the particle size, it can be exploited to selectively address particles with the same density from a polydisperse mixture of active particles and move them in or out of the boundary region. This study provides a simple design strategy to fabricate artificial microswimmers whose two‐ or three‐dimensional swimming behavior can be controlled with light.

link (url) DOI [BibTex]

pf Singh, D. P., Uspal, W. E., Popescu, M. N., Wilson, L. G., Fischer, P. Photogravitactic Microswimmers Adv. Func. Mat., 28, pages: 1706660, Febuary 2018 (article)

link (url) DOI [BibTex]

Chiral Plasmonic Hydrogen Sensors

Matuschek, M., Singh, D. P., Hyeon-Ho, J., Nesterov, M., Weiss, T., Fischer, P., Neubrech, F., Na Liu, L.

Small, 14(7):1702990, Febuary 2018 (article)

Abstract

In this article, a chiral plasmonic hydrogen‐sensing platform using palladium‐based nanohelices is demonstrated. Such 3D chiral nanostructures fabricated by nanoglancing angle deposition exhibit strong circular dichroism both experimentally and theoretically. The chiroptical properties of the palladium nanohelices are altered upon hydrogen uptake and sensitively depend on the hydrogen concentration. Such properties are well suited for remote and spark‐free hydrogen sensing in the flammable range. Hysteresis is reduced, when an increasing amount of gold is utilized in the palladium‐gold hybrid helices. As a result, the linearity of the circular dichroism in response to hydrogen is significantly improved. The chiral plasmonic sensor scheme is of potential interest for hydrogen‐sensing applications, where good linearity and high sensitivity are required.

link (url) DOI [BibTex]

pf Matuschek, M., Singh, D. P., Hyeon-Ho, J., Nesterov, M., Weiss, T., Fischer, P., Neubrech, F., Na Liu, L. Chiral Plasmonic Hydrogen Sensors Small, 14(7):1702990, Febuary 2018 (article)

link (url) DOI [BibTex]

Acoustic Fabrication via the Assembly and Fusion of Particles

Melde, K., Choi, E., Wu, Z., Palagi, S., Qiu, T., Fischer, P.

Advanced Materials, 30(3):1704507, January 2018 (article)

Abstract

Acoustic assembly promises a route toward rapid parallel fabrication of whole objects directly from solution. This study reports the contact-free and maskless assembly, and fixing of silicone particles into arbitrary 2D shapes using ultrasound fields. Ultrasound passes through an acoustic hologram to form a target image. The particles assemble from a suspension along lines of high pressure in the image due to acoustic radiation forces and are then fixed (crosslinked) in a UV-triggered reaction. For this, the particles are loaded with a photoinitiator by solvent-induced swelling. This localizes the reaction and allows the bulk suspension to be reused. The final fabricated parts are mechanically stable and self-supporting.

link (url) DOI Project Page [BibTex]

pf Melde, K., Choi, E., Wu, Z., Palagi, S., Qiu, T., Fischer, P. Acoustic Fabrication via the Assembly and Fusion of Particles Advanced Materials, 30(3):1704507, January 2018 (article)

link (url) DOI Project Page [BibTex]

Distributed Event-Based State Estimation for Networked Systems: An LMI Approach

Muehlebach, M., Trimpe, S.

IEEE Transactions on Automatic Control, 63(1):269-276, January 2018 (article)

am ics

arXiv (extended version) DOI Project Page [BibTex]

am ics Muehlebach, M., Trimpe, S. Distributed Event-Based State Estimation for Networked Systems: An LMI Approach IEEE Transactions on Automatic Control, 63(1):269-276, January 2018 (article)

arXiv (extended version) DOI Project Page [BibTex]

Combining learned and analytical models for predicting action effects

Kloss, A., Schaal, S., Bohg, J.

arXiv, 2018 (article) Submitted

Abstract

One of the most basic skills a robot should possess is predicting the effect of physical interactions with objects in the environment. This enables optimal action selection to reach a certain goal state. Traditionally, dynamics are approximated by physics-based analytical models. These models rely on specific state representations that may be hard to obtain from raw sensory data, especially if no knowledge of the object shape is assumed. More recently, we have seen learning approaches that can predict the effect of complex physical interactions directly from sensory input. It is however an open question how far these models generalize beyond their training data. In this work, we investigate the advantages and limitations of neural network based learning approaches for predicting the effects of actions based on sensory input and show how analytical and learned models can be combined to leverage the best of both worlds. As physical interaction task, we use planar pushing, for which there exists a well-known analytical model and a large real-world dataset. We propose to use a convolutional neural network to convert raw depth images or organized point clouds into a suitable representation for the analytical model and compare this approach to using neural networks for both, perception and prediction. A systematic evaluation of the proposed approach on a very large real-world dataset shows two main advantages of the hybrid architecture. Compared to a pure neural network, it significantly (i) reduces required training data and (ii) improves generalization to novel physical interaction.

arXiv pdf link (url) [BibTex]

am Kloss, A., Schaal, S., Bohg, J. Combining learned and analytical models for predicting action effects arXiv, 2018 (article) Submitted

arXiv pdf link (url) [BibTex]

Immersive Low-Cost Virtual Reality Treatment for Phantom Limb Pain: Evidence from Two Cases

Ambron, E., Miller, A., Kuchenbecker, K. J., Buxbaum, L. J., Coslett, H. B.

Frontiers in Neurology, 9(67):1-7, 2018 (article)

DOI Project Page [BibTex]

hi Ambron, E., Miller, A., Kuchenbecker, K. J., Buxbaum, L. J., Coslett, H. B. Immersive Low-Cost Virtual Reality Treatment for Phantom Limb Pain: Evidence from Two Cases Frontiers in Neurology, 9(67):1-7, 2018 (article)

DOI Project Page [BibTex]

Nanorobots propel through the eye

Zhiguang Wu, J. T. H. J. Q. W. M. S. F. Z. Z. W. M. D. S. S. T. Q. P. F.

Max Planck Society, 2018 (mpi_year_book)

Abstract

Scientists at the Max Planck Institute for Intelligent Systems in Stuttgart developed specially coated nanometer-sized robots that could be moved actively through dense tissue like the vitreous of the eye. So far, the transport of such nano-vehicles has only been demonstrated in model systems or biological fluids, but not in real tissue. Our work constitutes one step further towards nanorobots becoming minimally-invasive tools for precisely delivering medicine to where it is needed.

link (url) [BibTex]

pf Zhiguang Wu, J. T. H. J. Q. W. M. S. F. Z. Z. W. M. D. S. S. T. Q. P. F. Nanorobots propel through the eye Max Planck Society, 2018 (mpi_year_book)

link (url) [BibTex]

2005

Composite adaptive control with locally weighted statistical learning

Nakanishi, J., Farrell, J. A., Schaal, S.

Neural Networks, 18(1):71-90, January 2005, clmc (article)

Abstract

This paper introduces a provably stable learning adaptive control framework with statistical learning. The proposed algorithm employs nonlinear function approximation with automatic growth of the learning network according to the nonlinearities and the working domain of the control system. The unknown function in the dynamical system is approximated by piecewise linear models using a nonparametric regression technique. Local models are allocated as necessary and their parameters are optimized on-line. Inspired by composite adaptive control methods, the proposed learning adaptive control algorithm uses both the tracking error and the estimation error to update the parameters. We first discuss statistical learning of nonlinear functions, and motivate our choice of the locally weighted learning framework. Second, we begin with a class of first order SISO systems for theoretical development of our learning adaptive control framework, and present a stability proof including a parameter projection method that is needed to avoid potential singularities during adaptation. Then, we generalize our adaptive controller to higher order SISO systems, and discuss further extension to MIMO problems. Finally, we evaluate our theoretical control framework in numerical simulations to illustrate the effectiveness of the proposed learning adaptive controller for rapid convergence and high accuracy of control.

link (url) [BibTex]

2005

am Nakanishi, J., Farrell, J. A., Schaal, S. Composite adaptive control with locally weighted statistical learning Neural Networks, 18(1):71-90, January 2005, clmc (article)

link (url) [BibTex]

Nonlinear optical spectroscopy of chiral molecules

Fischer, P., Hache, F.

CHIRALITY, 17(8):421-437, 2005 (article)

Abstract

We review nonlinear optical processes that are specific to chiral molecules in solution and on surfaces. In contrast to conventional natural optical activity phenomena, which depend linearly on the electric field strength of the optical field, we discuss how optical processes that are nonlinear (quadratic, cubic, and quartic) functions of the electromagnetic field strength may probe optically active centers and chiral vibrations. We show that nonlinear techniques open entirely new ways of exploring chirality in chemical and biological systems: The cubic processes give rise to nonlinear circular dichroism and nonlinear optical rotation and make it possible to observe dynamic chiral processes at ultrafast time scales. The quadratic second-harmonic and sum-frequency-generation phenomena and the quartic processes may arise entirely in the electric-dipole approximation and do not require the use of circularly polarized light to detect chirality: They provide surface selectivity and their observables can be relatively much larger than in linear optical activity. These processes also give rise to the generation of light at a new color, and in liquids this frequency conversion only occurs if the solution is optically active. We survey recent chiral nonlinear optical experiments and give examples of their application to problems of biophysical interest. (C) 2005 Wiley-Liss, Inc.

DOI [BibTex]

pf Fischer, P., Hache, F. Nonlinear optical spectroscopy of chiral molecules CHIRALITY, 17(8):421-437, 2005 (article)

DOI [BibTex]

Negative refraction at optical frequencies in nonmagnetic two-component molecular media

Chen, Y., Fischer, P., Wise, F.

PHYSICAL REVIEW LETTERS, 95(6), 2005 (article)

Abstract

There is significant motivation to develop media with negative refractive indices at optical frequencies, but efforts in this direction are hampered by the weakness of the magnetic response at such frequencies. We show theoretically that a nonmagnetic medium with two atomic or molecular constituents can exhibit a negative refractive index. A negative index is possible even when the real parts of both the permittivity and permeability are positive. This surprising result provides a route to isotropic negative-index media at optical frequencies.

DOI [BibTex]

pf Chen, Y., Fischer, P., Wise, F. Negative refraction at optical frequencies in nonmagnetic two-component molecular media PHYSICAL REVIEW LETTERS, 95(6), 2005 (article)

DOI [BibTex]

A model of smooth pursuit based on learning of the target dynamics using only retinal signals

Shibata, T., Tabata, H., Schaal, S., Kawato, M.

Neural Networks, 18, pages: 213-225, 2005, clmc (article)

Abstract

While the predictive nature of the primate smooth pursuit system has been evident through several behavioural and neurophysiological experiments, few models have attempted to explain these results comprehensively. The model we propose in this paper in line with previous models employing optimal control theory; however, we hypothesize two new issues: (1) the medical superior temporal (MST) area in the cerebral cortex implements a recurrent neural network (RNN) in order to predict the current or future target velocity, and (2) a forward model of the target motion is acquired by on-line learning. We use stimulation studies to demonstrate how our new model supports these hypotheses.

link (url) [BibTex]