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2008


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A non-parametric Bayesian alternative to spike sorting

Wood, F., Black, M. J.

J. Neuroscience Methods, 173(1):1–12, August 2008 (article)

Abstract
The analysis of extra-cellular neural recordings typically begins with careful spike sorting and all analysis of the data then rests on the correctness of the resulting spike trains. In many situations this is unproblematic as experimental and spike sorting procedures often focus on well isolated units. There is evidence in the literature, however, that errors in spike sorting can occur even with carefully collected and selected data. Additionally, chronically implanted electrodes and arrays with fixed electrodes cannot be easily adjusted to provide well isolated units. In these situations, multiple units may be recorded and the assignment of waveforms to units may be ambiguous. At the same time, analysis of such data may be both scientifically important and clinically relevant. In this paper we address this issue using a novel probabilistic model that accounts for several important sources of uncertainty and error in spike sorting. In lieu of sorting neural data to produce a single best spike train, we estimate a probabilistic model of spike trains given the observed data. We show how such a distribution over spike sortings can support standard neuroscientific questions while providing a representation of uncertainty in the analysis. As a representative illustration of the approach, we analyzed primary motor cortical tuning with respect to hand movement in data recorded with a chronic multi-electrode array in non-human primates.We found that the probabilistic analysis generally agrees with human sorters but suggests the presence of tuned units not detected by humans.

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pdf preprint pdf from publisher PubMed [BibTex]

2008


pdf preprint pdf from publisher PubMed [BibTex]


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Neural control of computer cursor velocity by decoding motor cortical spiking activity in humans with tetraplegia

(J. Neural Engineering Highlights of 2008 Collection)

Kim, S., Simeral, J., Hochberg, L., Donoghue, J. P., Black, M. J.

J. Neural Engineering, 5, pages: 455–476, 2008 (article)

Abstract
Computer-mediated connections between human motor cortical neurons and assistive devices promise to improve or restore lost function in people with paralysis. Recently, a pilot clinical study of an intracortical neural interface system demonstrated that a tetraplegic human was able to obtain continuous two-dimensional control of a computer cursor using neural activity recorded from his motor cortex. This control, however, was not sufficiently accurate for reliable use in many common computer control tasks. Here, we studied several central design choices for such a system including the kinematic representation for cursor movement, the decoding method that translates neuronal ensemble spiking activity into a control signal and the cursor control task used during training for optimizing the parameters of the decoding method. In two tetraplegic participants, we found that controlling a cursor’s velocity resulted in more accurate closed-loop control than controlling its position directly and that cursor velocity control was achieved more rapidly than position control. Control quality was further improved over conventional linear filters by using a probabilistic method, the Kalman filter, to decode human motor cortical activity. Performance assessment based on standard metrics used for the evaluation of a wide range of pointing devices demonstrated significantly improved cursor control with velocity rather than position decoding.

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pdf preprint pdf from publisher [BibTex]

pdf preprint pdf from publisher [BibTex]


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ENHANCED ADHESION OF PDMS SURFACES FUNCTIONALIZED BY POLY (n-BUTYL ACRYLATE) BRUSHES INSPIRED BY GECKO FOOT HAIRS

Nese, A., Lee, H., Dong, H., Aksak, B., Cusick, B., Kowalewski, T., Matyjaszewski, K., Sitti, M.

Polymer Preprints, 49(2):107, 2008 (article)

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[BibTex]

[BibTex]


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Design and development of the lifting and propulsion mechanism for a biologically inspired water runner robot

Floyd, S., Sitti, M.

IEEE transactions on robotics, 24(3):698-709, IEEE, 2008 (article)

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[BibTex]

[BibTex]


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Control of Cell Behavior by Aligned Micro/Nanofibrous Biomaterial Scaffolds Fabricated by Spinneret-Based Tunable Engineered Parameters (STEP) Technique

Nain, A. S., Phillippi, J. A., Sitti, M., MacKrell, J., Campbell, P. G., Amon, C.

Small, 4(8):1153-1159, Wiley Online Library, 2008 (article)

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[BibTex]

[BibTex]


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Brownian Warps for Non-Rigid Registration

Mads Nielsen, Peter Johansen, Andrew Jackson, Benny Lautrup, Soren Hauberg

Journal of Mathematical Imaging and Vision, 31, pages: 221-231, Springer Netherlands, 2008 (article)

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Publishers site PDF [BibTex]

Publishers site PDF [BibTex]


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Rolling and spinning friction characterization of fine particles using lateral force microscopy based contact pushing

Sümer, B., Sitti, M.

Journal of Adhesion Science and Technology, 22(5-6):481-506, Taylor & Francis Group, 2008 (article)

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[BibTex]

[BibTex]


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Modeling the soft backing layer thickness effect on adhesion of elastic microfiber arrays

Long, R., Hui, C., Kim, S., Sitti, M.

Journal of Applied Physics, 104(4):044301, AIP, 2008 (article)

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Project Page [BibTex]

Project Page [BibTex]


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Cross-talk compensation in atomic force microscopy

Onal, C. D., Sümer, B., Sitti, M.

Review of scientific instruments, 79(10):103706, AIP, 2008 (article)

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[BibTex]

[BibTex]


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An Efficient Algorithm for Modelling Duration in Hidden Markov Models, with a Dramatic Application

Soren Hauberg, Jakob Sloth

Journal of Mathematical Imaging and Vision, 31, pages: 165-170, Springer Netherlands, 2008 (article)

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Publishers site Paper site PDF [BibTex]

Publishers site Paper site PDF [BibTex]


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Adhesion of biologically inspired oil-coated polymer micropillars

Cheung, E., Sitti, M.

Journal of Adhesion Science and Technology, 22(5-6):569-589, Taylor & Francis Group, 2008 (article)

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[BibTex]

[BibTex]


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Vision-based feedback strategy for controlled pushing of microparticles

Lynch, N. A., Onal, C. D., Schuster, E., Sitti, M.

Journal of Micro-Nano Mechatronics, 4(1-2):73-83, Springer-Verlag, 2008 (article)

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[BibTex]

[BibTex]


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Effect of quantity and configuration of attached bacteria on bacterial propulsion of microbeads

Behkam, B., Sitti, M.

Applied Physics Letters, 93(22):223901, AIP, 2008 (article)

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[BibTex]

[BibTex]


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Preface to the Journal of Micro-Nano Mechatronics

Dario, P., Fukuda, T., Sitti, M.

Journal of Micro-Nano Mechatronics, 4(1-2):1-1, Springer-Verlag, 2008 (article)

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[BibTex]

[BibTex]


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A legged anchoring mechanism for capsule endoscopes using micropatterned adhesives

Glass, P., Cheung, E., Sitti, M.

IEEE Transactions on Biomedical Engineering, 55(12):2759-2767, IEEE, 2008 (article)

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Project Page [BibTex]

Project Page [BibTex]


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Dynamic modeling of stick slip motion in an untethered magnetic microrobot

Pawashe, C., Floyd, S., Sitti, M.

Proceedings of Robotics: Science and Systems IV, Zurich, Switzerland, 2008 (article)

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[BibTex]

[BibTex]

2005


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Representing cyclic human motion using functional analysis

Ormoneit, D., Black, M. J., Hastie, T., Kjellström, H.

Image and Vision Computing, 23(14):1264-1276, December 2005 (article)

Abstract
We present a robust automatic method for modeling cyclic 3D human motion such as walking using motion-capture data. The pose of the body is represented by a time-series of joint angles which are automatically segmented into a sequence of motion cycles. The mean and the principal components of these cycles are computed using a new algorithm that enforces smooth transitions between the cycles by operating in the Fourier domain. Key to this method is its ability to automatically deal with noise and missing data. A learned walking model is then exploited for Bayesian tracking of 3D human motion.

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pdf pdf from publisher DOI [BibTex]

2005


pdf pdf from publisher DOI [BibTex]

2004


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On the variability of manual spike sorting

Wood, F., Black, M. J., Vargas-Irwin, C., Fellows, M., Donoghue, J. P.

IEEE Trans. Biomedical Engineering, 51(6):912-918, June 2004 (article)

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pdf pdf from publisher [BibTex]

2004


pdf pdf from publisher [BibTex]


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Modeling and decoding motor cortical activity using a switching Kalman filter

Wu, W., Black, M. J., Mumford, D., Gao, Y., Bienenstock, E., Donoghue, J. P.

IEEE Trans. Biomedical Engineering, 51(6):933-942, June 2004 (article)

Abstract
We present a switching Kalman filter model for the real-time inference of hand kinematics from a population of motor cortical neurons. Firing rates are modeled as a Gaussian mixture where the mean of each Gaussian component is a linear function of hand kinematics. A “hidden state” models the probability of each mixture component and evolves over time in a Markov chain. The model generalizes previous encoding and decoding methods, addresses the non-Gaussian nature of firing rates, and can cope with crudely sorted neural data common in on-line prosthetic applications.

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pdf pdf from publisher [BibTex]

pdf pdf from publisher [BibTex]


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E. Coli Inspired Propulsion for Swimming Microrobots

Behkam, Bahareh, Sitti, Metin

pages: 1037–1041, 2004 (article)

Abstract
Medical applications are among the most fascinating areas of microrobotics. For long, scientists have dreamed of miniature smart devices that can travel inside the human body and carry out a host of complex operations such as minimally invasive surgery (MIS), highly localized drug delivery, and screening for diseases that are in their very early stages. Still a distant dream, significant progress in micro and nanotechnology brings us closer to materializing it. For such a miniature device to be injected into the body, it has to be 800 μm or smaller in diameter. Miniature, safe and energy efficient propulsion systems hold the key to maturing this technology but they pose significant challenges. Scaling the macroscale natation mechanisms to micro/nano length scales is unfeasible. It has been estimated that a vibrating-fin driven swimming robot shorter than 6 mm can not overcome the viscous drag forces in water. In this paper, the authors propose a new type of propulsion inspired by the motility mechanism of bacteria with peritrichous flagellation, such as Escherichia coli, Salmonella typhimurium and Serratia marcescens. The perfomance of the propulsive mechanism is estimated by modeling the dynamics of the motion. The motion of the moving organelle is simulated and key parameters such as velocity, distribution of force and power requirments for different configurations of the tail are determined theoretically. In order to validate the theoretical result, a scaled up model of the swimming robot is fabricated and characterized in silicone oil using the Buckingham PI theorem for scaling. The results are compared with the theoretically computed values. These robots are intended to swim in stagnation/low velocity biofluid and reach currently inaccessible areas of the human body for disease inspection and possibly treatment. Potential target regions to use these robots include eyeball cavity, cerebrospinal fluid and the urinary system.

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link (url) DOI [BibTex]

link (url) DOI [BibTex]


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Atomic force microscope probe based controlled pushing for nanotribological characterization

Sitti, M.

IEEE/ASME Transactions on mechatronics, 9(2):343-349, IEEE, 2004 (article)

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[BibTex]

[BibTex]

1998


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Summarization of video-taped presentations: Automatic analysis of motion and gesture

Ju, S. X., Black, M. J., Minneman, S., Kimber, D.

IEEE Trans. on Circuits and Systems for Video Technology, 8(5):686-696, September 1998 (article)

Abstract
This paper presents an automatic system for analyzing and annotating video sequences of technical talks. Our method uses a robust motion estimation technique to detect key frames and segment the video sequence into subsequences containing a single overhead slide. The subsequences are stabilized to remove motion that occurs when the speaker adjusts their slides. Any changes remaining between frames in the stabilized sequences may be due to speaker gestures such as pointing or writing, and we use active contours to automatically track these potential gestures. Given the constrained domain, we define a simple set of actions that can be recognized based on the active contour shape and motion. The recognized actions provide an annotation of the sequence that can be used to access a condensed version of the talk from a Web page.

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pdf pdf from publisher DOI [BibTex]

1998


pdf pdf from publisher DOI [BibTex]


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Robust anisotropic diffusion

Black, M. J., Sapiro, G., Marimont, D., Heeger, D.

IEEE Transactions on Image Processing, 7(3):421-432, March 1998 (article)

Abstract
Relations between anisotropic diffusion and robust statistics are described in this paper. Specifically, we show that anisotropic diffusion can be seen as a robust estimation procedure that estimates a piecewise smooth image from a noisy input image. The edge-stopping; function in the anisotropic diffusion equation is closely related to the error norm and influence function in the robust estimation framework. This connection leads to a new edge-stopping; function based on Tukey's biweight robust estimator that preserves sharper boundaries than previous formulations and improves the automatic stopping of the diffusion. The robust statistical interpretation also provides a means for detecting the boundaries (edges) between the piecewise smooth regions in an image that has been smoothed with anisotropic diffusion. Additionally, we derive a relationship between anisotropic diffusion and regularization with line processes. Adding constraints on the spatial organization of the line processes allows us to develop new anisotropic diffusion equations that result in a qualitative improvement in the continuity of edges

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pdf pdf from publisher [BibTex]

pdf pdf from publisher [BibTex]


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Tele-nanorobotics using an atomic force microscope as a nanorobot and sensor

Sitti, M., Hashimoto, H.

Advanced Robotics, 13(4):417-436, Taylor & Francis, 1998 (article)

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[BibTex]

[BibTex]


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PLAYBOT: A visually-guided robot for physically disabled children

Tsotsos, J. K., Verghese, G., Dickinson, S., Jenkin, M., Jepson, A., Milios, E., Nuflo, F., Stevenson, S., Black, M., Metaxas, D., Culhane, S., Ye, Y., Mann, R.

Image & Vision Computing, Special Issue on Vision for the Disabled, 16(4):275-292, 1998 (article)

Abstract
This paper overviews the PLAYBOT project, a long-term, large-scale research program whose goal is to provide a directable robot which may enable physically disabled children to access and manipulate toys. This domain is the first test domain, but there is nothing inherent in the design of PLAYBOT that prohibits its extension to other tasks. The research is guided by several important goals: vision is the primary sensor; vision is task directed; the robot must be able to visually search its environment; object and event recognition are basic capabilities; environments must be natural and dynamic; users and environments are assumed to be unpredictable; task direction and reactivity must be smoothly integrated; and safety is of high importance. The emphasis of the research has been on vision for the robot this is the most challenging research aspect and the major bottleneck to the development of intelligent robots. Since the control framework is behavior-based, the visual capabilities of PLAYBOT are described in terms of visual behaviors. Many of the components of PLAYBOT are briefly described and several examples of implemented sub-systems are shown. The paper concludes with a description of the current overall system implementation, and a complete example of PLAYBOT performing a simple task.

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pdf pdf from publisher DOI [BibTex]

pdf pdf from publisher DOI [BibTex]


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EigenTracking: Robust matching and tracking of articulated objects using a view-based representation

Black, M. J., Jepson, A.

International Journal of Computer Vision, 26(1):63-84, 1998 (article)

Abstract
This paper describes an approach for tracking rigid and articulated objects using a view-based representation. The approach builds on and extends work on eigenspace representations, robust estimation techniques, and parameterized optical flow estimation. First, we note that the least-squares image reconstruction of standard eigenspace techniques has a number of problems and we reformulate the reconstruction problem as one of robust estimation. Second we define a “subspace constancy assumption” that allows us to exploit techniques for parameterized optical flow estimation to simultaneously solve for the view of an object and the affine transformation between the eigenspace and the image. To account for large affine transformations between the eigenspace and the image we define a multi-scale eigenspace representation and a coarse-to-fine matching strategy. Finally, we use these techniques to track objects over long image sequences in which the objects simultaneously undergo both affine image motions and changes of view. In particular we use this “EigenTracking” technique to track and recognize the gestures of a moving hand.

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pdf pdf from publisher video [BibTex]