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2019


The acoustic hologram and particle manipulation with structured acoustic fields
The acoustic hologram and particle manipulation with structured acoustic fields

Melde, K.

Karlsruher Institut für Technologie (KIT), May 2019 (phdthesis)

Abstract
This thesis presents holograms as a novel approach to create arbitrary ultrasound fields. It is shown how any wavefront can simply be encoded in the thickness profile of a phase plate. Contemporary 3D-printers enable fabrication of structured surfaces with feature sizes corresponding to wavelengths of ultrasound up to 7.5 MHz in water—covering the majority of medical and industrial applications. The whole workflow for designing and creating acoustic holograms has been developed and is presented in this thesis. To reconstruct the encoded fields a single transducer element is sufficient. Arbitrary fields are demonstrated in transmission and reflection configurations in water and air and validated by extensive hydrophone scans. To complement these time-consuming measurements a new approach, based on thermography, is presented, which enables volumetric sound field scans in just a few seconds. Several original experiments demonstrate the advantages of using acoustic holograms for particle manipulation. Most notably, directed parallel assembly of microparticles in the shape of a projected acoustic image has been shown and extended to a fabrication method by fusing the particles in a polymerization reaction. Further, seemingly dynamic propulsion from a static hologram is demonstrated by controlling the phase gradient along a projected track. The necessary complexity to create ultrasound fields with set amplitude and phase distributions is easily managed using acoustic holograms. The acoustic hologram is a simple and cost-effective tool for shaping ultrasound fields with high-fidelity. It is expected to have an impact in many applications where ultrasound is employed.

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link (url) DOI [BibTex]

2019



Dynamics of self-propelled colloids and their application as active matter
Dynamics of self-propelled colloids and their application as active matter

Choudhury, U.

University of Groningen, Zernike Institute for Advanced Materials, 2019 (phdthesis)

Abstract
In this thesis, the behavior of active particles spanning from single particle dynamics to collective behavior of many particles is explored. Active colloids are out-of equilibrium systems that have been studied extensively over the past 15 years. This thesis addresses several phenomena that arise in the field of active colloids.

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link (url) [BibTex]

link (url) [BibTex]

2018


Nanoscale robotic agents in biological fluids and tissues
Nanoscale robotic agents in biological fluids and tissues

Palagi, S., Walker, D. Q. T., Fischer, P.

In The Encyclopedia of Medical Robotics, 2, pages: 19-42, 2, (Editors: Desai, J. P. and Ferreira, A.), World Scientific, October 2018 (inbook)

Abstract
Nanorobots are untethered structures of sub-micron size that can be controlled in a non-trivial way. Such nanoscale robotic agents are envisioned to revolutionize medicine by enabling minimally invasive diagnostic and therapeutic procedures. To be useful, nanorobots must be operated in complex biological fluids and tissues, which are often difficult to penetrate. In this chapter, we first discuss potential medical applications of motile nanorobots. We briefly present the challenges related to swimming at such small scales and we survey the rheological properties of some biological fluids and tissues. We then review recent experimental results in the development of nanorobots and in particular their design, fabrication, actuation, and propulsion in complex biological fluids and tissues. Recent work shows that their nanoscale dimension is a clear asset for operation in biological tissues, since many biological tissues consist of networks of macromolecules that prevent the passage of larger micron-scale structures, but contain dynamic pores through which nanorobots can move.

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link (url) DOI [BibTex]

2018


link (url) DOI [BibTex]


Colloidal Chemical Nanomotors
Colloidal Chemical Nanomotors

Alarcon-Correa, M.

Colloidal Chemical Nanomotors, pages: 150, Cuvillier Verlag, MPI-IS , June 2018 (phdthesis)

Abstract
Synthetic sophisticated nanostructures represent a fundamental building block for the development of nanotechnology. The fabrication of nanoparticles complex in structure and material composition is key to build nanomachines that can operate as man-made nanoscale motors, which autonomously convert external energy into motion. To achieve this, asymmetric nanoparticles were fabricated combining a physical vapor deposition technique known as NanoGLAD and wet chemical synthesis. This thesis primarily concerns three complex colloidal systems that have been developed: i)Hollow nanocup inclusion complexes that have a single Au nanoparticle in their pocket. The Au particle can be released with an external trigger. ii)The smallest self-propelling nanocolloids that have been made to date, which give rise to a local concentration gradient that causes enhanced diffusion of the particles. iii)Enzyme-powered pumps that have been assembled using bacteriophages as biological nanoscaffolds. This construct also can be used for enzyme recovery after heterogeneous catalysis.

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[BibTex]

[BibTex]

2017


Chapter 8 - Micro- and nanorobots in Newtonian and biological viscoelastic fluids
Chapter 8 - Micro- and nanorobots in Newtonian and biological viscoelastic fluids

Palagi, S., (Walker) Schamel, D., Qiu, T., Fischer, P.

In Microbiorobotics, pages: 133 - 162, 8, Micro and Nano Technologies, Second edition, Elsevier, Boston, March 2017 (incollection)

Abstract
Swimming microorganisms are a source of inspiration for small scale robots that are intended to operate in fluidic environments including complex biomedical fluids. Nature has devised swimming strategies that are effective at small scales and at low Reynolds number. These include the rotary corkscrew motion that, for instance, propels a flagellated bacterial cell, as well as the asymmetric beat of appendages that sperm cells or ciliated protozoa use to move through fluids. These mechanisms can overcome the reciprocity that governs the hydrodynamics at small scale. The complex molecular structure of biologically important fluids presents an additional challenge for the effective propulsion of microrobots. In this chapter it is shown how physical and chemical approaches are essential in realizing engineered abiotic micro- and nanorobots that can move in biomedically important environments. Interestingly, we also describe a microswimmer that is effective in biological viscoelastic fluids that does not have a natural analogue.

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link (url) DOI [BibTex]

2017


link (url) DOI [BibTex]