Header logo is


2016


System and method to magnetically actuate a capsule endoscopic robot for diagnosis and treatment
System and method to magnetically actuate a capsule endoscopic robot for diagnosis and treatment

Sitti, M., Yim, S.

May 2016, US Patent 9,445,711 (patent)

Abstract
Present invention describes a swallowable device with a soft, compliant exterior, whose shape can be changed through the use of magnetic fields, and which can be locomoted in a rolling motion through magnetic control from the exterior of the patient. The present invention could be used for a variety of medical applications inside the GI tract including but not limited to drug delivery, biopsy, heat cauterization, pH sensing, biochemical sensing, micro-surgery, and active imaging.

pi

link (url) [BibTex]


Implications of Action-Oriented Paradigm Shifts in Cognitive Science
Implications of Action-Oriented Paradigm Shifts in Cognitive Science

Dominey, P. F., Prescott, T. J., Bohg, J., Engel, A. K., Gallagher, S., Heed, T., Hoffmann, M., Knoblich, G., Prinz, W., Schwartz, A.

In The Pragmatic Turn - Toward Action-Oriented Views in Cognitive Science, 18, pages: 333-356, 20, Strüngmann Forum Reports, vol. 18, J. Lupp, series editor, (Editors: Andreas K. Engel and Karl J. Friston and Danica Kragic), The MIT Press, 18th Ernst Strüngmann Forum, May 2016 (incollection) In press

Abstract
An action-oriented perspective changes the role of an individual from a passive observer to an actively engaged agent interacting in a closed loop with the world as well as with others. Cognition exists to serve action within a landscape that contains both. This chapter surveys this landscape and addresses the status of the pragmatic turn. Its potential influence on science and the study of cognition are considered (including perception, social cognition, social interaction, sensorimotor entrainment, and language acquisition) and its impact on how neuroscience is studied is also investigated (with the notion that brains do not passively build models, but instead support the guidance of action). A review of its implications in robotics and engineering includes a discussion of the application of enactive control principles to couple action and perception in robotics as well as the conceptualization of system design in a more holistic, less modular manner. Practical applications that can impact the human condition are reviewed (e.g. educational applications, treatment possibilities for developmental and psychopathological disorders, the development of neural prostheses). All of this foreshadows the potential societal implications of the pragmatic turn. The chapter concludes that an action-oriented approach emphasizes a continuum of interaction between technical aspects of cognitive systems and robotics, biology, psychology, the social sciences, and the humanities, where the individual is part of a grounded cultural system.

am

The Pragmatic Turn - Toward Action-Oriented Views in Cognitive Science 18th Ernst Strüngmann Forum Bibliography Chapter link (url) [BibTex]

The Pragmatic Turn - Toward Action-Oriented Views in Cognitive Science 18th Ernst Strüngmann Forum Bibliography Chapter link (url) [BibTex]


no image
Autofocusing-based correction of B0 fluctuation-induced ghosting

Loktyushin, A., Ehses, P., Schölkopf, B., Scheffler, K.

24th Annual Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM), May 2016 (poster)

ei

link (url) [BibTex]

link (url) [BibTex]


Learning Action-Perception Cycles in Robotics: A Question of Representations and Embodiment
Learning Action-Perception Cycles in Robotics: A Question of Representations and Embodiment

Bohg, J., Kragic, D.

In The Pragmatic Turn - Toward Action-Oriented Views in Cognitive Science, 18, pages: 309-320, 18, Strüngmann Forum Reports, vol. 18, J. Lupp, series editor, (Editors: Andreas K. Engel and Karl J. Friston and Danica Kragic), The MIT Press, 18th Ernst Strüngmann Forum, May 2016 (incollection) In press

Abstract
Since the 1950s, robotics research has sought to build a general-purpose agent capable of autonomous, open-ended interaction with realistic, unconstrained environments. Cognition is perceived to be at the core of this process, yet understanding has been challenged because cognition is referred to differently within and across research areas, and is not clearly defined. The classic robotics approach is decomposition into functional modules which perform planning, reasoning, and problem-solving or provide input to these mechanisms. Although advancements have been made and numerous success stories reported in specific niches, this systems-engineering approach has not succeeded in building such a cognitive agent. The emergence of an action-oriented paradigm offers a new approach: action and perception are no longer separable into functional modules but must be considered in a complete loop. This chapter reviews work on different mechanisms for action- perception learning and discusses the role of embodiment in the design of the underlying representations and learning. It discusses the evaluation of agents and suggests the development of a new embodied Turing Test. Appropriate scenarios need to be devised in addition to current competitions, so that abilities can be tested over long time periods.

am

18th Ernst Strüngmann Forum The Pragmatic Turn- Toward Action-Oriented Views in Cognitive Science Bibliography Chapter link (url) [BibTex]

18th Ernst Strüngmann Forum The Pragmatic Turn- Toward Action-Oriented Views in Cognitive Science Bibliography Chapter link (url) [BibTex]


no image
Distinct adaptation to abrupt and gradual torque perturbations with a multi-joint exoskeleton robot

Oh, Y., Sutanto, G., Mistry, M., Schweighofer, N., Schaal, S.

Abstracts of Neural Control of Movement Conference (NCM 2016), Montego Bay, Jamaica, April 2016 (poster)

am

[BibTex]

[BibTex]


Remotely addressable magnetic composite micro-actuators
Remotely addressable magnetic composite micro-actuators

Sitti, M., Diller, E., Miyashita, S.

Febuary 2016, US Patent App. 15/018,008 (patent)

Abstract
The present invention describes methods to fabricate actuators that can be remotely controlled in an addressable manner, and methods to provide remote control such micro-actuators. The actuators are composites of two permanent magnet materials, one of which is has high coercivity, and the other of which switches magnetization direction by applied fields. By switching the second material's magnetization direction, the two magnets either work together or cancel each other, resulting in distinct “on” and “off” behavior of the devices. The device can be switched “on” or “off” remotely using a field pulse of short duration.

pi

[BibTex]

[BibTex]


Remotely addressable magnetic composite micro-actuators
Remotely addressable magnetic composite micro-actuators

Sitti, M., Diller, E., Miyashita, S.

Febuary 2016, US Patent 9,281,112 (patent)

Abstract
The present invention describes methods to fabricate actuators that can be remotely controlled in an addressable manner, and methods to provide remote control such micro-actuators. The actuators are composites of two permanent magnet materials, one of which is has high coercivity, and the other of which switches magnetization direction by applied fields. By switching the second material's magnetization direction, the two magnets either work together or cancel each other, resulting in distinct “on” and “off” behavior of the devices. The device can be switched “on” or “off” remotely using a field pulse of short duration.

pi

link (url) [BibTex]

link (url) [BibTex]


no image
Annales des Concours 2016 MP Mathématiques, Informatique

Batog, G., Dumont, J., Puyhaubert, V.

In corrigés des problèmes posés aux concours CCP, Centrale/Supélec, Mines/Ponts, X/ENS, 2016 (inbook)

H&K Éditions [BibTex]

H&K Éditions [BibTex]


no image
Sustainable effects of simulator-based training on ecological driving

Lüderitz, C., Wirzberger, M., Karrer-Gauß, K.

In Advances in Ergonomic Design of Systems, Products and Processes. Proceedings of the Annual Meeting of the GfA 2015, pages: 463-475, Springer, 2016 (inbook)

Abstract
Simulation-based driver training offers a promising way to teach ecological driving behavior under controlled, comparable conditions. In a study with 23 professional drivers, we tested the effectiveness of such training. The driving behavior of a training group in a simulated drive with and without instructions were compared. Ten weeks later, a repetition drive tested the long-term effect training. Driving data revealed reduced fuel consumption by ecological driving in both the guided and repetition drives. Driving time decreased significantly in the training and did not differ from driving time after 10 weeks. Results did not achieve significance for transfer to test drives in real traffic situations. This may be due to the small sample size and biased data as a result of unusual driving behavior. Finally, recent and promising approaches to support drivers in maintaining eco-driving styles beyond training situations are outlined.

re

DOI [BibTex]

DOI [BibTex]


no image
Nonlinear functional causal models for distinguishing cause from effect

Zhang, K., Hyvärinen, A.

In Statistics and Causality: Methods for Applied Empirical Research, pages: 185-201, 8, 1st, (Editors: Wolfgang Wiedermann and Alexander von Eye), John Wiley & Sons, Inc., 2016 (inbook)

ei

[BibTex]

[BibTex]


no image
Novel Random Forest based framework enables the segmentation of cerebral ischemic regions using multiparametric MRI

Katiyar, P., Castaneda, S., Patzwaldt, K., Russo, F., Poli, S., Ziemann, U., Disselhorst, J. A., Pichler, B. J.

European Molecular Imaging Meeting, 2016 (poster)

ei

link (url) [BibTex]

link (url) [BibTex]


no image
PGO wave-triggered functional MRI: mapping the networks underlying synaptic consolidation

Logothetis, N. K., Murayama, Y., Ramirez-Villegas, J. F., Besserve, M., Evrard, H.

47th Annual Meeting of the Society for Neuroscience (Neuroscience), 2016 (poster)

ei

[BibTex]

[BibTex]


no image
A cognitive brain–computer interface for patients with amyotrophic lateral sclerosis

Hohmann, M., Fomina, T., Jayaram, V., Widmann, N., Förster, C., Just, J., Synofzik, M., Schölkopf, B., Schöls, L., Grosse-Wentrup, M.

In Brain-Computer Interfaces: Lab Experiments to Real-World Applications, 228(Supplement C):221-239, 8, Progress in Brain Research, (Editors: Damien Coyle), Elsevier, 2016 (incollection)

ei

DOI Project Page [BibTex]

DOI Project Page [BibTex]


no image
Analysis of multiparametric MRI using a semi-supervised random forest framework allows the detection of therapy response in ischemic stroke

Castaneda, S., Katiyar, P., Russo, F., Calaminus, C., Disselhorst, J. A., Ziemann, U., Kohlhofer, U., Quintanilla-Martinez, L., Poli, S., Pichler, B. J.

World Molecular Imaging Conference, 2016 (talk)

ei

link (url) [BibTex]

link (url) [BibTex]


no image
Multiparametric Imaging of Ischemic Stroke using [89Zr]-Desferal-EPO-PET/MRI in combination with Gaussian Mixture Modeling enables unsupervised lesions identification

Castaneda, S., Katiyar, P., Russo, F., Maurer, A., Patzwaldt, K., Poli, S., Calaminus, C., Disselhorst, J. A., Ziemann, U., Pichler, B. J.

European Molecular Imaging Meeting, 2016 (poster)

ei

link (url) [BibTex]

link (url) [BibTex]


Method for encapsulating a nanostructure, coated nanostructure and use of a coated nanostructure
Method for encapsulating a nanostructure, coated nanostructure and use of a coated nanostructure

Jeong, H. H., Lee, T. C., Fischer, P.

Google Patents, 2016, WO Patent App. PCT/EP2016/056,377 (patent)

Abstract
The present invention relates to a method for encapsulating a nanostructure, the method comprising the steps of: -providing a substrate; -forming a plug composed of plug material at said substrate; -forming a nanostructure (on or) at said plug; -forming a shell composed of at least one shell material on external surfaces of the nanostructure, with the at least one shell material covering said nanostructure and at least some of the plug material,whereby the shell and the plug encapsulate the nanostructure. The invention further relates to a coated nanostructure and to the use of a coated nanostructure.

pf

link (url) [BibTex]


no image
Locally Weighted Regression for Control

Ting, J., Meier, F., Vijayakumar, S., Schaal, S.

In Encyclopedia of Machine Learning and Data Mining, pages: 1-14, Springer US, Boston, MA, 2016 (inbook)

am

link (url) DOI [BibTex]

link (url) DOI [BibTex]


no image
Statistical source separation of rhythmic LFP patterns during sharp wave ripples in the macaque hippocampus

Ramirez-Villegas, J. F., Logothetis, N. K., Besserve, M.

47th Annual Meeting of the Society for Neuroscience (Neuroscience), 2016 (poster)

ei

[BibTex]

[BibTex]


no image
Multi-view learning on multiparametric PET/MRI quantifies intratumoral heterogeneity and determines therapy efficacy

Katiyar, P., Divine, M. R., Kohlhofer, U., Quintanilla-Martinez, L., Siegemund, M., Pfizenmaier, K., Kontermann, R., Pichler, B. J., Disselhorst, J. A.

World Molecular Imaging Conference, 2016 (talk)

ei

link (url) [BibTex]

link (url) [BibTex]


no image
Hippocampal neural events predict ongoing brain-wide BOLD activity

Besserve, M., Logothetis, N. K.

47th Annual Meeting of the Society for Neuroscience (Neuroscience), 2016 (poster)

ei

[BibTex]

[BibTex]

2015


Untethered Magnetic Micromanipulation
Untethered Magnetic Micromanipulation

Diller, E., Sitti, M.

In Micro-and Nanomanipulation Tools, 13, 10, Wiley-VCH Verlag GmbH & Co. KGaA, November 2015 (inbook)

Abstract
This chapter discusses the methods and state of the art in microscale manipulation in remote environments using untethered microrobotic devices. It focuses on manipulation at the size scale of tens to hundreds of microns, where small size leads to a dominance of microscale physical effects and challenges in fabrication and actuation. To motivate the challenges of operating at this size scale, the chapter includes coverage of the physical forces relevant to microrobot motion and manipulation below the millimeter-size scale. It then introduces the actuation methods commonly used in untethered manipulation schemes, with particular focus on magnetic actuation due to its wide use in the field. The chapter divides these manipulation techniques into two types: contact manipulation, which relies on direct pushing or grasping of objects for motion, and noncontact manipulation, which relies indirectly on induced fluid flow from the microrobot motion to move objects without any direct contact.

pi

DOI Project Page [BibTex]

2015


DOI Project Page [BibTex]


no image
Diversity of sharp wave-ripples in the CA1 of the macaque hippocampus and their brain wide signatures

Ramirez-Villegas, J. F., Logothetis, N. K., Besserve, M.

45th Annual Meeting of the Society for Neuroscience (Neuroscience 2015), October 2015 (poster)

ei

link (url) [BibTex]

link (url) [BibTex]


no image
Causal Inference for Empirical Time Series Based on the Postulate of Independence of Cause and Mechanism

Besserve, M.

53rd Annual Allerton Conference on Communication, Control, and Computing, September 2015 (talk)

ei

[BibTex]

[BibTex]


Methods of forming dry adhesive structures
Methods of forming dry adhesive structures

Sitti, M., Murphy, M., Aksak, B.

September 2015, US Patent 9,120,953 (patent)

Abstract
Methods of forming dry adhesives including a method of making a dry adhesive including applying a liquid polymer to the second end of the stem, molding the liquid polymer on the stem in a mold, wherein the mold includes a recess having a cross-sectional area that is less than a cross-sectional area of the second end of the stem, curing the liquid polymer in the mold to form a tip at the second end of the stem, wherein the tip includes a second layer stem; corresponding to the recess in the mold, and removing the tip from the mold after the liquid polymer cures.

pi

[BibTex]

[BibTex]


Micro-fiber arrays with tip coating and transfer method for preparing same
Micro-fiber arrays with tip coating and transfer method for preparing same

Sitti, M., Washburn, N. R., Glass, P. S., Chung, H.

July 2015, US Patent 9,079,215 (patent)

Abstract
Present invention describes a patterned and coated micro- and nano-scale fibers elastomeric material for enhanced adhesion in wet or dry environments. A multi-step fabrication process including optical lithography, micromolding, polymer synthesis, dipping, stamping, and photopolymerization is described to produce uniform arrays of micron-scale fibers with mushroom-shaped tips coated with a thin layer of an intrinsically adhesive synthetic polymer, such as lightly crosslinked p(DMA-co-MEA).

pi

[BibTex]

[BibTex]


no image
Kernel methods in medical imaging

Charpiat, G., Hofmann, M., Schölkopf, B.

In Handbook of Biomedical Imaging, pages: 63-81, 4, (Editors: Paragios, N., Duncan, J. and Ayache, N.), Springer, Berlin, Germany, June 2015 (inbook)

ei

Web link (url) [BibTex]

Web link (url) [BibTex]


no image
Retrospective rigid motion correction of undersampled MRI data

Loktyushin, A., Babayeva, M., Gallichan, D., Krueger, G., Scheffler, K., Kober, T.

23rd Annual Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine, ISMRM, June 2015 (poster)

ei

[BibTex]

[BibTex]


no image
Improving Quantitative Susceptibility and R2* Mapping by Applying Retrospective Motion Correction

Feng, X., Loktyushin, A., Deistung, A., Reichenbach, J. R.

23rd Annual Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine, ISMRM, June 2015 (poster)

ei

[BibTex]

[BibTex]


no image
Lernende Roboter

Trimpe, S.

In Jahrbuch der Max-Planck-Gesellschaft, Max Planck Society, May 2015, (popular science article in German) (inbook)

am ics

link (url) [BibTex]

link (url) [BibTex]


no image
Autonomous Robots

Schaal, S.

In Jahrbuch der Max-Planck-Gesellschaft, May 2015 (incollection)

am

[BibTex]

[BibTex]


no image
Independence of cause and mechanism in brain networks

Besserve, M.

DALI workshop on Networks: Processes and Causality, April 2015 (talk)

ei

[BibTex]

[BibTex]


Dry adhesives and methods for making dry adhesives
Dry adhesives and methods for making dry adhesives

Sitti, M., Murphy, M., Aksak, B.

March 2015, US Patent App. 14/625,162 (patent)

Abstract
Dry adhesives and methods for forming dry adhesives. A method of forming a dry adhesive structure on a substrate, comprises: forming a template backing layer of energy sensitive material on the substrate; forming a template layer of energy sensitive material on the template backing layer; exposing the template layer to a predetermined pattern of energy; removing a portion of the template layer related to the predetermined pattern of energy, and leaving a template structure formed from energy sensitive material and connected to the substrate via the template backing layer.

pi

[BibTex]

[BibTex]


no image
Increasing the sensitivity of Kepler to Earth-like exoplanets

Foreman-Mackey, D., Hogg, D., Schölkopf, B., Wang, D.

Workshop: 225th American Astronomical Society Meeting 2015 , pages: 105.01D, 2015 (poster)

ei

Web link (url) [BibTex]

Web link (url) [BibTex]


no image
Information-Theoretic Implications of Classical and Quantum Causal Structures

Chaves, R., Majenz, C., Luft, L., Maciel, T., Janzing, D., Schölkopf, B., Gross, D.

18th Conference on Quantum Information Processing (QIP), 2015 (talk)

ei

Web link (url) [BibTex]

Web link (url) [BibTex]


no image
Calibrating the pixel-level Kepler imaging data with a causal data-driven model

Wang, D., Foreman-Mackey, D., Hogg, D., Schölkopf, B.

Workshop: 225th American Astronomical Society Meeting 2015 , pages: 258.08, 2015 (poster)

ei

Web link (url) [BibTex]

Web link (url) [BibTex]


no image
Assessment of brain tissue damage in the Sub-Acute Stroke Region by Multiparametric Imaging using [89-Zr]-Desferal-EPO-PET/MRI

Castaneda, S. G., Katiyar, P., Russo, F., Disselhorst, J. A., Calaminus, C., Poli, S., Maurer, A., Ziemann, U., Pichler, B. J.

World Molecular Imaging Conference, 2015 (talk)

ei

[BibTex]

[BibTex]


no image
Statistical and Machine Learning Methods for Neuroimaging: Examples, Challenges, and Extensions to Diffusion Imaging Data

O’Donnell, L. J., Schultz, T.

In Visualization and Processing of Higher Order Descriptors for Multi-Valued Data, pages: 299-319, (Editors: Hotz, I. and Schultz, T.), Springer, 2015 (inbook)

ei

[BibTex]

[BibTex]


no image
Early time point in vivo PET/MR is a promising biomarker for determining efficacy of a novel Db(\alphaEGFR)-scTRAIL fusion protein therapy in a colon cancer model

Divine, M. R., Harant, M., Katiyar, P., Disselhorst, J. A., Bukala, D., Aidone, S., Siegemund, M., Pfizenmaier, K., Kontermann, R., Pichler, B. J.

World Molecular Imaging Conference, 2015 (talk)

ei

[BibTex]

[BibTex]


no image
Perception of Deformable Objects and Compliant Manipulation for Service Robots

Stueckler, J., Behnke, S.

In Soft Robotics: From Theory to Applications, Springer, 2015 (inbook)

ev

link (url) [BibTex]

link (url) [BibTex]


no image
Assessment of tumor heterogeneity using unsupervised graph based clustering of multi-modality imaging data

Katiyar, P., Divine, M. R., Pichler, B. J., Disselhorst, J. A.

European Molecular Imaging Meeting, 2015 (poster)

ei

[BibTex]

[BibTex]


Tacit Learning for Emergence of Task-Related Behaviour through Signal Accumulation
Tacit Learning for Emergence of Task-Related Behaviour through Signal Accumulation

Berenz, V., Alnajjar, F., Hayashibe, M., Shimoda, S.

In Emergent Trends in Robotics and Intelligent Systems: Where is the Role of Intelligent Technologies in the Next Generation of Robots?, pages: 31-38, Springer International Publishing, Cham, 2015 (inbook)

am

link (url) DOI [BibTex]

link (url) DOI [BibTex]


no image
Annales des Concours 2015 PC Mathématiques, Informatique

Batog, G., Dumont, J., Puyhaubert, V.

In corrigés des problèmes posés aux concours CCP, Centrale/Supélec, Mines/Ponts, X/ENS, 2015 (inbook)

H&K Éditions [BibTex]

H&K Éditions [BibTex]


no image
The search for single exoplanet transits in the Kepler light curves

Foreman-Mackey, D., Hogg, D. W., Schölkopf, B.

IAU General Assembly, 22, pages: 2258352, 2015 (talk)

ei

link (url) [BibTex]

link (url) [BibTex]


no image
Disparity estimation from a generative light field model

Köhler, R., Schölkopf, B., Hirsch, M.

IEEE International Conference on Computer Vision (ICCV 2015), Workshop on Inverse Rendering, 2015, Note: This work has been presented as a poster and is not included in the workshop proceedings. (poster)

ei

[BibTex]

[BibTex]


no image
Justifying Information-Geometric Causal Inference

Janzing, D., Steudel, B., Shajarisales, N., Schölkopf, B.

In Measures of Complexity: Festschrift for Alexey Chervonenkis, pages: 253-265, 18, (Editors: Vovk, V., Papadopoulos, H. and Gammerman, A.), Springer, 2015 (inbook)

ei

DOI [BibTex]

DOI [BibTex]


no image
Robot Learning

Peters, J., Lee, D., Kober, J., Nguyen-Tuong, D., Bagnell, J. A., Schaal, S.

In Springer Handbook of Robotics 2nd Edition, pages: 1371-1394, Springer Berlin Heidelberg, Berlin, Heidelberg, 2015 (incollection)

am

[BibTex]

[BibTex]

2011


no image
Projected Newton-type methods in machine learning

Schmidt, M., Kim, D., Sra, S.

In Optimization for Machine Learning, pages: 305-330, (Editors: Sra, S., Nowozin, S. and Wright, S. J.), MIT Press, Cambridge, MA, USA, December 2011 (inbook)

Abstract
We consider projected Newton-type methods for solving large-scale optimization problems arising in machine learning and related fields. We first introduce an algorithmic framework for projected Newton-type methods by reviewing a canonical projected (quasi-)Newton method. This method, while conceptually pleasing, has a high computation cost per iteration. Thus, we discuss two variants that are more scalable, namely, two-metric projection and inexact projection methods. Finally, we show how to apply the Newton-type framework to handle non-smooth objectives. Examples are provided throughout the chapter to illustrate machine learning applications of our framework.

ei

PDF Web [BibTex]

2011


PDF Web [BibTex]


no image
Combined whole-body PET/MR imaging: MR contrast agents do not affect the quantitative accuracy of PET following attenuation correction

Lois, C., Kupferschläger, J., Bezrukov, I., Schmidt, H., Werner, M., Mannheim, J., Pichler, B., Schwenzer, N., Beyer, T.

(SST15-05 ), 97th Scientific Assemble and Annual Meeting of the Radiological Society of North America (RSNA), December 2011 (talk)

Abstract
PURPOSE Combined PET/MR imaging entails the use of MR contrast agents (MRCA) as part of integrated protocols. We assess additional attenuation of the PET emission signals in the presence of oral and intraveneous (iv) MRCA made up of iron oxide and Gd-chelates, respectively. METHOD AND MATERIALS Phantom scans were performed on a clinical PET/CT (Biograph HiRez16, Siemens) and integrated whole-body PET/MR (Biograph mMR, Siemens) using oral (Lumirem) and intraveneous (Gadovist) MRCA. Reference PET attenuation values were determined on a small-animal PET (Inveon, Siemens) using standard PET transmission imaging (TX). Seven syringes of 5mL were filled with (a) Water, (b) Lumirem_100 (100% conc.), (c) Gadovist_100 (100%), (d) Gadovist_18 (18%), (e) Gadovist_02 (0.2%), (f) Imeron-400 CT iv-contrast (100%) and (g) Imeron-400 (2.4%). The same set of syringes was scanned on CT (Sensation16, Siemens) at 120kVp and 160mAs. The effect of MRCA on the attenuation of PET emission data was evaluated using a 20cm cylinder filled uniformly with [18F]-FDG (FDG) in water (BGD). Three 4.5cm diameter cylinders were inserted into the phantom: (C1) Teflon, (C2) Water+FDG (2:1) and (C3) Lumirem_100+FDG (2:1). Two 50mL syringes filled with Gadovist_02+FDG (Sy1) and water+FDG (Sy2) were attached to the sides of (C1) to mimick the effects of iv-contrast in vessels near bone. Syringe-to-background activity ratio was 4-to-1. PET emission data were acquired for 10min each using the PET/CT and the PET/MR. Images were reconstructed using CT- and MR-based attenuation correction. RESULTS Mean linear PET attenuation (cm-1) on TX was (a) 0.098, (b) 0.098, (c) 0.300, (d) 0.134, (e) 0.095, (f) 0.397 and (g) 0.105. Corresponding CT attenuation (HU) was: (a) 5, (b) 14, (c) 3070, (d) 1040, (e) 13, (f) 3070 and (g) 347. Lumirem had little effect on PET attenuation with (C3) being 13% and 10% higher than (C2) on PET/CT and PET/MR, respectively. Gadovist_02 had even smaller effects with (Sy1) being 2.5% lower than (Sy2) on PET/CT and 1.2% higher than (Sy2) on PET/MR. CONCLUSION MRCA in high and clinically relevant concentrations have attenuation values similar to that of CT contrast and water, respectively. In clinical PET/MR scenarios MRCA are not expected to lead to significant attenuation of the PET emission signals.

ei

Web [BibTex]

Web [BibTex]