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2015


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Untethered Magnetic Micromanipulation

Diller, E., Sitti, M.

In Micro-and Nanomanipulation Tools, 13, 10, Wiley-VCH Verlag GmbH & Co. KGaA, November 2015 (inbook)

Abstract
This chapter discusses the methods and state of the art in microscale manipulation in remote environments using untethered microrobotic devices. It focuses on manipulation at the size scale of tens to hundreds of microns, where small size leads to a dominance of microscale physical effects and challenges in fabrication and actuation. To motivate the challenges of operating at this size scale, the chapter includes coverage of the physical forces relevant to microrobot motion and manipulation below the millimeter-size scale. It then introduces the actuation methods commonly used in untethered manipulation schemes, with particular focus on magnetic actuation due to its wide use in the field. The chapter divides these manipulation techniques into two types: contact manipulation, which relies on direct pushing or grasping of objects for motion, and noncontact manipulation, which relies indirectly on induced fluid flow from the microrobot motion to move objects without any direct contact.

pi

DOI Project Page [BibTex]

2015


DOI Project Page [BibTex]


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easyGWAS: An Integrated Computational Framework for Advanced Genome-Wide Association Studies

Grimm, Dominik

Eberhard Karls Universität Tübingen, November 2015 (phdthesis)

ei

[BibTex]

[BibTex]


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Causal Discovery Beyond Conditional Independences

Sgouritsa, E.

Eberhard Karls Universität Tübingen, Germany, October 2015 (phdthesis)

ei

link (url) [BibTex]

link (url) [BibTex]


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Gaussian Process Optimization for Self-Tuning Control

Marco, A.

Polytechnic University of Catalonia (BarcelonaTech), October 2015 (mastersthesis)

am ics

PDF Project Page [BibTex]

PDF Project Page [BibTex]


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Causal Inference for Empirical Time Series Based on the Postulate of Independence of Cause and Mechanism

Besserve, M.

53rd Annual Allerton Conference on Communication, Control, and Computing, September 2015 (talk)

ei

[BibTex]

[BibTex]


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From Points to Probability Measures: A Statistical Learning on Distributions with Kernel Mean Embedding

Muandet, K.

University of Tübingen, Germany, University of Tübingen, Germany, September 2015 (phdthesis)

ei

[BibTex]

[BibTex]


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Machine Learning Approaches to Image Deconvolution

Schuler, C.

University of Tübingen, Germany, University of Tübingen, Germany, September 2015 (phdthesis)

ei

[BibTex]

[BibTex]


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Adaptive and Learning Concepts in Hydraulic Force Control

Doerr, A.

University of Stuttgart, September 2015 (mastersthesis)

am ics

[BibTex]

[BibTex]


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Kernel methods in medical imaging

Charpiat, G., Hofmann, M., Schölkopf, B.

In Handbook of Biomedical Imaging, pages: 63-81, 4, (Editors: Paragios, N., Duncan, J. and Ayache, N.), Springer, Berlin, Germany, June 2015 (inbook)

ei

Web link (url) [BibTex]

Web link (url) [BibTex]


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Object Detection Using Deep Learning - Learning where to search using visual attention

Kloss, A.

Eberhard Karls Universität Tübingen, May 2015 (mastersthesis)

Abstract
Detecting and identifying the different objects in an image fast and reliably is an important skill for interacting with one’s environment. The main problem is that in theory, all parts of an image have to be searched for objects on many different scales to make sure that no object instance is missed. It however takes considerable time and effort to actually classify the content of a given image region and both time and computational capacities that an agent can spend on classification are limited. Humans use a process called visual attention to quickly decide which locations of an image need to be processed in detail and which can be ignored. This allows us to deal with the huge amount of visual information and to employ the capacities of our visual system efficiently. For computer vision, researchers have to deal with exactly the same problems, so learning from the behaviour of humans provides a promising way to improve existing algorithms. In the presented master’s thesis, a model is trained with eye tracking data recorded from 15 participants that were asked to search images for objects from three different categories. It uses a deep convolutional neural network to extract features from the input image that are then combined to form a saliency map. This map provides information about which image regions are interesting when searching for the given target object and can thus be used to reduce the parts of the image that have to be processed in detail. The method is based on a recent publication of Kümmerer et al., but in contrast to the original method that computes general, task independent saliency, the presented model is supposed to respond differently when searching for different target categories.

am

PDF Project Page [BibTex]


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Blind Retrospective Motion Correction of MR Images

Loktyushin, A.

University of Tübingen, Germany, May 2015 (phdthesis)

ei

[BibTex]

[BibTex]


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Robot Arm Tracking with Random Decision Forests

Widmaier, F.

Eberhard-Karls-Universität Tübingen, May 2015 (mastersthesis)

Abstract
For grasping and manipulation with robot arms, knowing the current pose of the arm is crucial for successful controlling its motion. Often, pose estimations can be acquired from encoders inside the arm, but they can have significant inaccuracy which makes the use of additional techniques necessary. In this master thesis, a novel approach of robot arm pose estimation is presented, that works on single depth images without the need of prior foreground segmentation or other preprocessing steps. A random regression forest is used, which is trained only on synthetically generated data. The approach improves former work by Bohg et al. by considerably reducing the computational effort both at training and test time. The forest in the new method directly estimates the desired joint angles while in the former approach, the forest casts 3D position votes for the joints, which then have to be clustered and fed into an iterative inverse kinematic process to finally get the joint angles. To improve the estimation accuracy, the standard training objective of the forest training is replaced by a specialized function that makes use of a model-dependent distance metric, called DISP. Experimental results show that the specialized objective indeed improves pose estimation and it is shown that the method, despite of being trained on synthetic data only, is able to provide reasonable estimations for real data at test time.

am

PDF Project Page [BibTex]

PDF Project Page [BibTex]


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Lernende Roboter

Trimpe, S.

In Jahrbuch der Max-Planck-Gesellschaft, Max Planck Society, May 2015, (popular science article in German) (inbook)

am ics

link (url) [BibTex]

link (url) [BibTex]


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Shape Models of the Human Body for Distributed Inference

Zuffi, S.

Brown University, May 2015 (phdthesis)

Abstract
In this thesis we address the problem of building shape models of the human body, in 2D and 3D, which are realistic and efficient to use. We focus our efforts on the human body, which is highly articulated and has interesting shape variations, but the approaches we present here can be applied to generic deformable and articulated objects. To address efficiency, we constrain our models to be part-based and have a tree-structured representation with pairwise relationships between connected parts. This allows the application of methods for distributed inference based on message passing. To address realism, we exploit recent advances in computer graphics that represent the human body with statistical shape models learned from 3D scans. We introduce two articulated body models, a 2D model, named Deformable Structures (DS), which is a contour-based model parameterized for 2D pose and projected shape, and a 3D model, named Stitchable Puppet (SP), which is a mesh-based model parameterized for 3D pose, pose-dependent deformations and intrinsic body shape. We have successfully applied the models to interesting and challenging problems in computer vision and computer graphics, namely pose estimation from static images, pose estimation from video sequences, pose and shape estimation from 3D scan data. This advances the state of the art in human pose and shape estimation and suggests that carefully de ned realistic models can be important for computer vision. More work at the intersection of vision and graphics is thus encouraged.

ps

PDF [BibTex]


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Autonomous Robots

Schaal, S.

In Jahrbuch der Max-Planck-Gesellschaft, May 2015 (incollection)

am

[BibTex]

[BibTex]


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Independence of cause and mechanism in brain networks

Besserve, M.

DALI workshop on Networks: Processes and Causality, April 2015 (talk)

ei

[BibTex]

[BibTex]


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From Scans to Models: Registration of 3D Human Shapes Exploiting Texture Information

Bogo, F.

University of Padova, March 2015 (phdthesis)

Abstract
New scanning technologies are increasing the importance of 3D mesh data, and of algorithms that can reliably register meshes obtained from multiple scans. Surface registration is important e.g. for building full 3D models from partial scans, identifying and tracking objects in a 3D scene, creating statistical shape models. Human body registration is particularly important for many applications, ranging from biomedicine and robotics to the production of movies and video games; but obtaining accurate and reliable registrations is challenging, given the articulated, non-rigidly deformable structure of the human body. In this thesis, we tackle the problem of 3D human body registration. We start by analyzing the current state of the art, and find that: a) most registration techniques rely only on geometric information, which is ambiguous on flat surface areas; b) there is a lack of adequate datasets and benchmarks in the field. We address both issues. Our contribution is threefold. First, we present a model-based registration technique for human meshes that combines geometry and surface texture information to provide highly accurate mesh-to-mesh correspondences. Our approach estimates scene lighting and surface albedo, and uses the albedo to construct a high-resolution textured 3D body model that is brought into registration with multi-camera image data using a robust matching term. Second, by leveraging our technique, we present FAUST (Fine Alignment Using Scan Texture), a novel dataset collecting 300 high-resolution scans of 10 people in a wide range of poses. FAUST is the first dataset providing both real scans and automatically computed, reliable "ground-truth" correspondences between them. Third, we explore possible uses of our approach in dermatology. By combining our registration technique with a melanocytic lesion segmentation algorithm, we propose a system that automatically detects new or evolving lesions over almost the entire body surface, thus helping dermatologists identify potential melanomas. We conclude this thesis investigating the benefits of using texture information to establish frame-to-frame correspondences in dynamic monocular sequences captured with consumer depth cameras. We outline a novel approach to reconstruct realistic body shape and appearance models from dynamic human performances, and show preliminary results on challenging sequences captured with a Kinect.

ps

[BibTex]


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Long Range Motion Estimation and Applications

Sevilla-Lara, L.

Long Range Motion Estimation and Applications, University of Massachusetts Amherst, University of Massachusetts Amherst, Febuary 2015 (phdthesis)

Abstract
Finding correspondences between images underlies many computer vision problems, such as optical flow, tracking, stereovision and alignment. Finding these correspondences involves formulating a matching function and optimizing it. This optimization process is often gradient descent, which avoids exhaustive search, but relies on the assumption of being in the basin of attraction of the right local minimum. This is often the case when the displacement is small, and current methods obtain very accurate results for small motions. However, when the motion is large and the matching function is bumpy this assumption is less likely to be true. One traditional way of avoiding this abruptness is to smooth the matching function spatially by blurring the images. As the displacement becomes larger, the amount of blur required to smooth the matching function becomes also larger. This averaging of pixels leads to a loss of detail in the image. Therefore, there is a trade-off between the size of the objects that can be tracked and the displacement that can be captured. In this thesis we address the basic problem of increasing the size of the basin of attraction in a matching function. We use an image descriptor called distribution fields (DFs). By blurring the images in DF space instead of in pixel space, we in- crease the size of the basin attraction with respect to traditional methods. We show competitive results using DFs both in object tracking and optical flow. Finally we demonstrate an application of capturing large motions for temporal video stitching.

ps

[BibTex]

[BibTex]


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Policy Search for Imitation Learning

Doerr, A.

University of Stuttgart, January 2015 (thesis)

am ics

link (url) Project Page [BibTex]

link (url) Project Page [BibTex]


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Information-Theoretic Implications of Classical and Quantum Causal Structures

Chaves, R., Majenz, C., Luft, L., Maciel, T., Janzing, D., Schölkopf, B., Gross, D.

18th Conference on Quantum Information Processing (QIP), 2015 (talk)

ei

Web link (url) [BibTex]

Web link (url) [BibTex]


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A Cognitive Brain-Computer Interface for Patients with Amyotrophic Lateral Sclerosis

Hohmann, M.

Graduate Training Centre of Neuroscience, University of Tübingen, Germany, 2015 (mastersthesis)

ei

[BibTex]

[BibTex]


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Sequential Image Deconvolution Using Probabilistic Linear Algebra

Gao, M.

Technical University of Munich, Germany, 2015 (mastersthesis)

ei

[BibTex]

[BibTex]


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Causal Inference in Neuroimaging

Casarsa de Azevedo, L.

Graduate Training Centre of Neuroscience, University of Tübingen, Germany, 2015 (mastersthesis)

ei

[BibTex]

[BibTex]


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The effect of frowning on attention

Ibarra Chaoul, A.

Graduate Training Centre of Neuroscience, University of Tübingen, Germany, 2015 (mastersthesis)

ei

[BibTex]

[BibTex]


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Justifying Information-Geometric Causal Inference

Janzing, D., Steudel, B., Shajarisales, N., Schölkopf, B.

In Measures of Complexity: Festschrift for Alexey Chervonenkis, pages: 253-265, 18, (Editors: Vovk, V., Papadopoulos, H. and Gammerman, A.), Springer, 2015 (inbook)

ei

DOI [BibTex]

DOI [BibTex]


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The search for single exoplanet transits in the Kepler light curves

Foreman-Mackey, D., Hogg, D. W., Schölkopf, B.

IAU General Assembly, 22, pages: 2258352, 2015 (talk)

ei

link (url) [BibTex]

link (url) [BibTex]


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Strukturelle und spektroskopische Eigenschaften epitaktischer FeMn/Co Exchange-Bias-Systeme

Schmidt, M.

Universität Stuttgart, Stuttgart, 2015 (phdthesis)

mms

link (url) DOI [BibTex]


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Ultraschnelles Vortexkernschalten

Noske, M.

Universität Stuttgart, Stuttgart (und Cuvillier Verlag, Göttingen), 2015 (phdthesis)

mms

[BibTex]

[BibTex]


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Investigations of unusual hard magnetic MnBi LTP phase, utilizing temperature dependent SQUID-FORC

Muralidhar, Shreyas

Universität Stuttgart, Stuttgart, 2015 (mastersthesis)

mms

[BibTex]

[BibTex]


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Magnetische Röntgenmikroskopie an Hochtemperatur-Supraleitern

Stahl, C.

Universität Stuttgart, Stuttgart (und Cuvillier Verlag, Göttingen), 2015 (phdthesis)

mms

[BibTex]

[BibTex]


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Voltage-induced magnetic manipulation of a microstructured iron gold multilayer system

Sittig, Robert

Universität Stuttgart, Stuttgart, 2015 (mastersthesis)

mms

[BibTex]

[BibTex]


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Transfer of angular momentum from the spin system to the lattice during ultrafast magnetization

Tsatsoulis, T.

Universität Stuttgart, Stuttgart, 2015 (mastersthesis)

mms

[BibTex]

[BibTex]


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Robot Learning

Peters, J., Lee, D., Kober, J., Nguyen-Tuong, D., Bagnell, J. A., Schaal, S.

In Springer Handbook of Robotics 2nd Edition, pages: 1371-1394, Springer Berlin Heidelberg, Berlin, Heidelberg, 2015 (incollection)

am

[BibTex]

[BibTex]


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Quantum kinetic theory of ultrafast demagnetization by electron-phonon scattering

Briones Paz, J. Z.

Universität Stuttgart, Stuttgart, 2015 (mastersthesis)

mms

[BibTex]

[BibTex]

2011


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Projected Newton-type methods in machine learning

Schmidt, M., Kim, D., Sra, S.

In Optimization for Machine Learning, pages: 305-330, (Editors: Sra, S., Nowozin, S. and Wright, S. J.), MIT Press, Cambridge, MA, USA, December 2011 (inbook)

Abstract
We consider projected Newton-type methods for solving large-scale optimization problems arising in machine learning and related fields. We first introduce an algorithmic framework for projected Newton-type methods by reviewing a canonical projected (quasi-)Newton method. This method, while conceptually pleasing, has a high computation cost per iteration. Thus, we discuss two variants that are more scalable, namely, two-metric projection and inexact projection methods. Finally, we show how to apply the Newton-type framework to handle non-smooth objectives. Examples are provided throughout the chapter to illustrate machine learning applications of our framework.

ei

PDF Web [BibTex]

2011


PDF Web [BibTex]


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Combined whole-body PET/MR imaging: MR contrast agents do not affect the quantitative accuracy of PET following attenuation correction

Lois, C., Kupferschläger, J., Bezrukov, I., Schmidt, H., Werner, M., Mannheim, J., Pichler, B., Schwenzer, N., Beyer, T.

(SST15-05 ), 97th Scientific Assemble and Annual Meeting of the Radiological Society of North America (RSNA), December 2011 (talk)

Abstract
PURPOSE Combined PET/MR imaging entails the use of MR contrast agents (MRCA) as part of integrated protocols. We assess additional attenuation of the PET emission signals in the presence of oral and intraveneous (iv) MRCA made up of iron oxide and Gd-chelates, respectively. METHOD AND MATERIALS Phantom scans were performed on a clinical PET/CT (Biograph HiRez16, Siemens) and integrated whole-body PET/MR (Biograph mMR, Siemens) using oral (Lumirem) and intraveneous (Gadovist) MRCA. Reference PET attenuation values were determined on a small-animal PET (Inveon, Siemens) using standard PET transmission imaging (TX). Seven syringes of 5mL were filled with (a) Water, (b) Lumirem_100 (100% conc.), (c) Gadovist_100 (100%), (d) Gadovist_18 (18%), (e) Gadovist_02 (0.2%), (f) Imeron-400 CT iv-contrast (100%) and (g) Imeron-400 (2.4%). The same set of syringes was scanned on CT (Sensation16, Siemens) at 120kVp and 160mAs. The effect of MRCA on the attenuation of PET emission data was evaluated using a 20cm cylinder filled uniformly with [18F]-FDG (FDG) in water (BGD). Three 4.5cm diameter cylinders were inserted into the phantom: (C1) Teflon, (C2) Water+FDG (2:1) and (C3) Lumirem_100+FDG (2:1). Two 50mL syringes filled with Gadovist_02+FDG (Sy1) and water+FDG (Sy2) were attached to the sides of (C1) to mimick the effects of iv-contrast in vessels near bone. Syringe-to-background activity ratio was 4-to-1. PET emission data were acquired for 10min each using the PET/CT and the PET/MR. Images were reconstructed using CT- and MR-based attenuation correction. RESULTS Mean linear PET attenuation (cm-1) on TX was (a) 0.098, (b) 0.098, (c) 0.300, (d) 0.134, (e) 0.095, (f) 0.397 and (g) 0.105. Corresponding CT attenuation (HU) was: (a) 5, (b) 14, (c) 3070, (d) 1040, (e) 13, (f) 3070 and (g) 347. Lumirem had little effect on PET attenuation with (C3) being 13% and 10% higher than (C2) on PET/CT and PET/MR, respectively. Gadovist_02 had even smaller effects with (Sy1) being 2.5% lower than (Sy2) on PET/CT and 1.2% higher than (Sy2) on PET/MR. CONCLUSION MRCA in high and clinically relevant concentrations have attenuation values similar to that of CT contrast and water, respectively. In clinical PET/MR scenarios MRCA are not expected to lead to significant attenuation of the PET emission signals.

ei

Web [BibTex]

Web [BibTex]


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Cooperative Cuts: a new use of submodularity in image segmentation

Jegelka, S.

Second I.S.T. Austria Symposium on Computer Vision and Machine Learning, October 2011 (talk)

ei

Web [BibTex]

Web [BibTex]


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Effect of MR Contrast Agents on Quantitative Accuracy of PET in Combined Whole-Body PET/MR Imaging

Lois, C., Bezrukov, I., Schmidt, H., Schwenzer, N., Werner, M., Pichler, B., Kupferschläger, J., Beyer, T.

2011(MIC3-3), 2011 IEEE Nuclear Science Symposium, Medical Imaging Conference (NSS-MIC), October 2011 (talk)

Abstract
Combined whole-body PET/MR systems are being tested in clinical practice today. Integrated imaging protocols entail the use of MR contrast agents (MRCA) that could bias PET attenuation correction. In this work, we assess the effect of MRCA in PET/MR imaging. We analyze the effect of oral and intravenous MRCA on PET activity after attenuation correction. We conclude that in clinical scenarios, MRCA are not expected to lead to significant attenuation of PET signals, and that attenuation maps are not biased after the ingestion of adequate oral contrasts.

ei

Web [BibTex]

Web [BibTex]


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First Results on Patients and Phantoms of a Fully Integrated Clinical Whole-Body PET/MRI

Schmidt, H., Schwenzer, N., Bezrukov, I., Kolb, A., Mantlik, F., Kupferschläger, J., Lois, C., Sauter, A., Brendle, C., Pfannenberg, C., Pichler, B.

2011(J2-8), 2011 IEEE Nuclear Science Symposium, Medical Imaging Conference (NSS-MIC), October 2011 (talk)

Abstract
First clinical fully integrated whole-body PET/MR scanners are just entering the field. Here, we present studies toward quantification accuracy and variation within the PET field of view of small lesions from our BrainPET/MRI, a dedicated clinical brain scanner which was installed three years ago in Tbingen. Also, we present first results for patient and phantom scans of a fully integral whole-body PET/MRI, which was installed two months ago at our department. The quantification accuracy and homogeneity of the BrainPET-Insert (Siemens Medical Solutions, Germany) installed inside the magnet bore of a clinical 3T MRI scanner (Magnetom TIM Trio, Siemens Medical Solutions, Germany) was evaluated by using eight hollow spheres with inner diameters from 3.95 to 7.86 mm placed at different positions inside a homogeneous cylinder phantom with an 9:1 and 6:1 sphere to background ratio. The quantification accuracy for small lesions at different positions in the PET FoV shows a standard deviation of up to 11% and is acceptable for quantitative brain studies where the homogeneity of quantification on the entire FoV is essental. Image quality and resolution of the new Siemens whole-body PET/MR system (Biograph mMR, Siemens Medical Solutions, Germany) was evaluated according to the NEMA NU2 2007 protocol using a body phantom containing six spheres with inner diameter from 10 to 37 mm at sphere to background ratios of 8:1 and 4:1 and the F-18 point sources located at different positions inside the PET FoV, respectively. The evaluation of the whole-body PET/MR system reveals a good PET image quality and resolution comparable to state-of-the-art clinical PET/CT scanners. First images of patient studies carried out at the whole-body PET/MR are presented highlighting the potency of combined PET/MR imaging.

ei

Web [BibTex]

Web [BibTex]


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Effect of MR contrast agents on quantitative accuracy of PET in combined whole-body PET/MR imaging

Lois, C., Kupferschläger, J., Bezrukov, I., Schmidt, H., Werner, M., Mannheim, J., Pichler, B., Schwenzer, N., Beyer, T.

(OP314), Annual Congress of the European Association of Nuclear Medicine (EANM), October 2011 (talk)

Abstract
PURPOSE:Combined PET/MR imaging entails the use of MR contrast agents (MRCA) as part of integrated protocols. MRCA are made up of iron oxide and Gd-chelates for oral and intravenous (iv) application, respectively. We assess additional attenuation of the PET emission signals in the presence of oral and iv MRCA.MATERIALS AND METHODS:Phantom scans were performed on a clinical PET/CT (Biograph HiRez16, Siemens) and an integrated whole-body PET/MR (Biograph mMR, Siemens). Two common MRCA were evaluated: Lumirem (oral) and Gadovist (iv).Reference PET attenuation values were determined on a dedicated small-animal PET (Inveon, Siemens) using equivalent standard PET transmission source imaging (TX). Seven syringes of 5mL were filled with (a) Water, (b) Lumirem_100 (100% concentration), (c) Gadovist_100 (100%), (d) Gadovist_18 (18%), (e) Gadovist_02 (0.2%), (f) Imeron-400 CT iv-contrast (100%) and (g) Imeron-400 (2.4%). The same set of syringes was scanned on CT (Sensation16, Siemens) at 120kVp and 160mAs.The effect of MRCA on the attenuation of PET emission data was evaluated using a 20cm cylinder filled uniformly with [18F]-FDG (FDG) in water (BGD). Three 4.5cm diameter cylinders were inserted into the phantom: (C1) Teflon, (C2) Water+FDG (2:1) and (C3) Lumirem_100+FDG (2:1). Two 50mL syringes filled with Gadovist_02+FDG (Sy1) and water+FDG (Sy2) were attached to the sides of (C1) to mimick the effects of iv-contrast in vessels near bone. Syringe-to-background activity ratio was 4-to-1.PET emission data were acquired for 10min each using the PET/CT and the PET/MR. Images were reconstructed using CT- and MR-based attenuation correction (AC). Since Teflon is not correctly identified on MR, PET(/MR) data were reconstructed using MR-AC and CT-AC.RESULTS:Mean linear PET attenuation (cm-1) on TX was (a) 0.098, (b) 0.098, (c) 0.300, (d) 0.134, (e) 0.095, (f) 0.397 and (g) 0.105. Corresponding CT attenuation (HU) was: (a) 5, (b) 14, (c) 3070, (d) 1040, (e) 13, (f) 3070 and (g) 347.Lumirem had little effect on PET attenuation with (C3) being 13%, 10% and 11% higher than (C2) on PET/CT, PET/MR with MR-AC, and PET/MR with CT-AC, respectively. Gadovist_02 had even smaller effects with (Sy1) being 2.5% lower, 1.2% higher, and 3.5% lower than (Sy2) on PET/CT, PET/MR with MR-AC and PET/MR with CT-AC, respectively.CONCLUSION:MRCA in high and clinically relevant concentrations have attenuation values similar to that of CT contrast and water, respectively. In clinical PET/MR scenarios MRCA are not expected to lead to significant attenuation of the PET emission signals.

ei

Web [BibTex]

Web [BibTex]


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Multi-parametric Tumor Characterization and Therapy Monitoring using Simultaneous PET/MRI: initial results for Lung Cancer and GvHD

Sauter, A., Schmidt, H., Gueckel, B., Brendle, C., Bezrukov, I., Mantlik, F., Kolb, A., Mueller, M., Reimold, M., Federmann, B., Hetzel, J., Claussen, C., Pfannenberg, C., Horger, M., Pichler, B., Schwenzer, N.

(T110), 2011 World Molecular Imaging Congress (WMIC), September 2011 (talk)

Abstract
Hybrid imaging modalities such as [18F]FDG-PET/CT are superior in staging of e.g. lung cancer disease compared with stand-alone modalities. Clinical PET/MRI systems are about to enter the field of hybrid imaging and offer potential advantages. One added value could be a deeper insight into the tumor metabolism and tumorigenesis due to the combination of PET and dedicated MR methods such as MRS and DWI. Additionally, therapy monitoring of diffucult to diagnose disease such as chronic sclerodermic GvHD (csGvHD) can potentially be improved by this combination. We have applied PET/MRI in 3 patients with lung cancer and 4 patients with csGvHD before and during therapy. All 3 patients had lung cancer confirmed by histology (2 adenocarcinoma, 1 carcinoid). First, a [18F]FDG-PET/CT was performed with the following parameters: injected dose 351.7±25.1 MBq, uptake time 59.0±2.6 min, 3 min/bed. Subsequently, patients were brought to the PET/MRI imaging facility. The whole-body PET/MRI Biograph mMR system comprises 56 detector cassettes with a 59.4 cm transaxial and 25.8 cm axial FoV. The MRI is a modified Verio system with a magnet bore of 60 cm. The following parameters for PET acquisition were applied: uptake time 121.3±2.3 min, 3 bed positions, 6 min/bed. T1w, T2w, and DWI MR images were recorded simultaneously for each bed. Acquired PET data were reconstructed with an iterative 3D OSEM algorithm using 3 iterations and 21 subsets, Gaussian filter of 3 mm. The 4 patients with GvHD were brought to the brainPET/MRI imaging facility 2:10h-2:28h after tracer injection. A 9 min brainPET-acquisition with simultaneous MRI of the lower extremities was accomplished. MRI examination included T1-weighted (pre and post gadolinium) and T2-weighted sequences. Attenuation correction was calculated based on manual bone segmentation and thresholds for soft tissue, fat and air. Soleus muscle (m), crural fascia (f1) and posterior crural intermuscular septum fascia (f2) were surrounded with ROIs based on the pre-treatment T1-weighted images and coregistered using IRW (Siemens). Fascia-to-muscle ratios for PET (f/m), T1 contrast uptake (T1_post-contrast_f-pre-contrast_f/post-contrast_m-pre-contrast_m) and T2 (T2_f/m) were calculated. Both patients with adenocarcinoma show a lower ADC value compared with the carcinoid patient suggesting a higher cellularity. This is also reflected in FDG-PET with higher SUV values. Our initial results reveal that PET/MRI can provide complementary information for a profound tumor characterization and therapy monitoring. The high soft tissue contrast provided by MRI is valuable for the assessment of the fascial inflammation. While in the first patient FDG and contrast uptake as well as edema, represented by T2 signals, decreased with ongoing therapy, all parameters remained comparatively stable in the second patient. Contrary to expectations, an increase in FDG uptake of patient 3 and 4 was accompanied by an increase of the T2 signals, but a decrease in contrast uptake. These initial results suggest that PET/MRI provides complementary information of the complex disease mechanisms in fibrosing disorders.

ei

Web [BibTex]

Web [BibTex]


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Statistical Image Analysis and Percolation Theory

Langovoy, M., Habeck, M., Schölkopf, B.

2011 Joint Statistical Meetings (JSM), August 2011 (talk)

Abstract
We develop a novel method for detection of signals and reconstruction of images in the presence of random noise. The method uses results from percolation theory. We specifically address the problem of detection of multiple objects of unknown shapes in the case of nonparametric noise. The noise density is unknown and can be heavy-tailed. The objects of interest have unknown varying intensities. No boundary shape constraints are imposed on the objects, only a set of weak bulk conditions is required. We view the object detection problem as hypothesis testing for discrete statistical inverse problems. We present an algorithm that allows to detect greyscale objects of various shapes in noisy images. We prove results on consistency and algorithmic complexity of our procedures. Applications to cryo-electron microscopy are presented.

ei

Web [BibTex]

Web [BibTex]


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Statistical Learning Theory: Models, Concepts, and Results

von Luxburg, U., Schölkopf, B.

In Handbook of the History of Logic, Vol. 10: Inductive Logic, 10, pages: 651-706, (Editors: Gabbay, D. M., Hartmann, S. and Woods, J. H.), Elsevier North Holland, Amsterdam, Netherlands, May 2011 (inbook)

Abstract
Statistical learning theory provides the theoretical basis for many of today's machine learning algorithms and is arguably one of the most beautifully developed branches of artificial intelligence in general. It originated in Russia in the 1960s and gained wide popularity in the 1990s following the development of the so-called Support Vector Machine (SVM), which has become a standard tool for pattern recognition in a variety of domains ranging from computer vision to computational biology. Providing the basis of new learning algorithms, however, was not the only motivation for developing statistical learning theory. It was just as much a philosophical one, attempting to answer the question of what it is that allows us to draw valid conclusions from empirical data. In this article we attempt to give a gentle, non-technical overview over the key ideas and insights of statistical learning theory. We do not assume that the reader has a deep background in mathematics, statistics, or computer science. Given the nature of the subject matter, however, some familiarity with mathematical concepts and notations and some intuitive understanding of basic probability is required. There exist many excellent references to more technical surveys of the mathematics of statistical learning theory: the monographs by one of the founders of statistical learning theory ([Vapnik, 1995], [Vapnik, 1998]), a brief overview over statistical learning theory in Section 5 of [Sch{\"o}lkopf and Smola, 2002], more technical overview papers such as [Bousquet et al., 2003], [Mendelson, 2003], [Boucheron et al., 2005], [Herbrich and Williamson, 2002], and the monograph [Devroye et al., 1996].

ei

PDF Web DOI [BibTex]

PDF Web DOI [BibTex]


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Crowdsourcing for optimisation of deconvolution methods via an iPhone application

Lang, A.

Hochschule Reutlingen, Germany, April 2011 (mastersthesis)

ei

[BibTex]

[BibTex]


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Cooperative Cuts

Jegelka, S.

COSA Workshop: Combinatorial Optimization, Statistics, and Applications, March 2011 (talk)

Abstract
Combinatorial problems with submodular cost functions have recently drawn interest. In a standard combinatorial problem, the sum-of-weights cost is replaced by a submodular set function. The result is a powerful model that is though very hard. In this talk, I will introduce cooperative cuts, minimum cuts with submodular edge weights. I will outline methods to approximately solve this problem, and show an application in computer vision. If time permits, the talk will also sketch regret-minimizing online algorithms for submodular-cost combinatorial problems. This is joint work with Jeff Bilmes (University of Washington).

ei

Web [BibTex]

Web [BibTex]


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Robot Learning

Peters, J., Tedrake, R., Roy, N., Morimoto, J.

In Encyclopedia of Machine Learning, pages: 865-869, Encyclopedia of machine learning, (Editors: Sammut, C. and Webb, G. I.), Springer, New York, NY, USA, January 2011 (inbook)

ei

PDF Web DOI [BibTex]

PDF Web DOI [BibTex]


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What You Expect Is What You Get? Potential Use of Contingent Negative Variation for Passive BCI Systems in Gaze-Based HCI

Ihme, K., Zander, TO.

In Affective Computing and Intelligent Interaction, 6975, pages: 447-456, Lecture Notes in Computer Science, (Editors: D’Mello, S., Graesser, A., Schuller, B. and Martin, J.-C.), Springer, Berlin, Germany, 2011 (inbook)

Abstract
When using eye movements for cursor control in human-computer interaction (HCI), it may be difficult to find an appropriate substitute for the click operation. Most approaches make use of dwell times. However, in this context the so-called Midas-Touch-Problem occurs which means that the system wrongly interprets fixations due to long processing times or spontaneous dwellings of the user as command. Lately it has been shown that brain-computer interface (BCI) input bears good prospects to overcome this problem using imagined hand movements to elicit a selection. The current approach tries to develop this idea further by exploring potential signals for the use in a passive BCI, which would have the advantage that the brain signals used as input are generated automatically without conscious effort of the user. To explore event-related potentials (ERPs) giving information about the user’s intention to select an object, 32-channel electroencephalography (EEG) was recorded from ten participants interacting with a dwell-time-based system. Comparing ERP signals during the dwell time with those occurring during fixations on a neutral cross hair, a sustained negative slow cortical potential at central electrode sites was revealed. This negativity might be a contingent negative variation (CNV) reflecting the participants’ anticipation of the upcoming selection. Offline classification suggests that the CNV is detectable in single trial (mean accuracy 74.9 %). In future, research on the CNV should be accomplished to ensure its stable occurence in human-computer interaction and render possible its use as a potential substitue for the click operation.

ei

DOI [BibTex]

DOI [BibTex]


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Kernel Methods in Bioinformatics

Borgwardt, KM.

In Handbook of Statistical Bioinformatics, pages: 317-334, Springer Handbooks of Computational Statistics ; 3, (Editors: Lu, H.H.-S., Schölkopf, B. and Zhao, H.), Springer, Berlin, Germany, 2011 (inbook)

Abstract
Kernel methods have now witnessed more than a decade of increasing popularity in the bioinformatics community. In this article, we will compactly review this development, examining the areas in which kernel methods have contributed to computational biology and describing the reasons for their success.

ei

PDF DOI [BibTex]

PDF DOI [BibTex]


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Cue Combination: Beyond Optimality

Rosas, P., Wichmann, F.

In Sensory Cue Integration, pages: 144-152, (Editors: Trommershäuser, J., Körding, K. and Landy, M. S.), Oxford University Press, 2011 (inbook)

ei

[BibTex]

[BibTex]