Director

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Prof. Dr. Joachim Spatz

Phone:+49 711 689-3611Fax:+ 49 711 689-3612
Email:spatz@...

Research

 

Latest News

New Paper: α5β1-integrin and MT1-MMP promote tumor cell migration in 2D but not in 3D fibronectin microenvironments. Corall, S., Haraszti, T., Bartoschik, T., Spatz, J. P., Ludwig, T., & Cavalcanti-Adam, E. A. (2014). α5β1-integrin and MT1-MMP promote tumor cell migration in 2D but not in 3D fibronectin microenvironments.Computational Mechanics, 53(3), 499-510. doi:10.1007/s00466-013-0960-6.

New Paper: Interface Immobilization Chemistry of cRGD-based Peptides Regulates Integrin Mediated Cell Adhesion. Pallarola, D., Bochen, A., Böhm, H., Rechenmacher, F., Sobahi, T., Spatz, J. P., et al. (2014). Interface Immobilization Chemistry of cRGD-based Peptides Regulates Integrin Mediated Cell Adhesion.Advanced Functional Materials, 24(7), 943-956. doi:10.1002/adfm.201302411.

New Paper: Biomimetic macroporous PEG hydrogels as 3D scaffolds for the multiplication of human hematopoietic stem and progenitor cells. Raic, A., Rödling, L., Kalbacher, H., & Lee-Thedieck, C. (2014). Biomimetic macroporous PEG hydrogels as 3D scaffolds for the multiplication of human hematopoietic stem and progenitor cells. Biomaterials,35, 929-940. doi:10.1016/j.biomaterials.2013.10.038.

 


New Materials and Biosystems (Spatz)

Investigation of the interaction between synthetic and living materials

 

 

Biophysics of Cellular Interactions

Synthetic Cell Systems

Cell Signaling and Adhesion

Technical Applications of Biomimetic Nanostructures

Supramolecular structures and micromechanics

Cell Mechanics and Migration

Semiconductor Nanomaterials

Single Molecule TIRF Microscopy on Nanostructured Surfaces

Hydrogels and Mechanotransduction

Nanomaterials for Optical and Sensoric Applications

Microfluidics for Synthetic Biology

Bionic Microgenerators and Tunneling Nanotubes (TNTs)

Photoswitchable Biointerphases

 

 

The Department explores fundamental and applied research topics in the area of biomaterials, biophysics and biomedicine. Its focus are novel functions and phenomema based on the self-organization of molecules, proteins, nanoparticles, bacteria, and cells as well as their chemical and physical manipulation. In this context we are developing new devices and biomaterial systems (e.g. photoswitchable molecules and proteins, structured interfaces for bio- and optically active interfaces as well as fiber systems for cell matrices) and shedding light on fundamental issues such as individual and collective cell migration, cellular interactions with their environment (cell-cell and cell-matrix adhesion) and, its influence on higher biological functions like immune responses, tissue development and regeneration, wound healing and tumor development. Moreover, the Department addresses issues in synthetic biology, how individual cell functions like cell adhesion and cell migration can be created synthetically. The latter topic is being funded by an ERC Advanced Grant of the EU (together with Benjamin Geiger from the Weizmann Institute of Science), among others.

 
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