List of Publications

journal cover: 14, 29, 35 
jounal video: 13


1. Medda R, Giske A, Cavalcanti-Adam EA. Challenges in imaging cell surface receptors. Themed issue Optical Methods in Nano-Biotechnology in Optics and Lasers in Engineering, article in press

2. Guasch J, Conings B, Neubauer S, Rechenmacher F, Ende K, Rolli CG, Kappel C, Schaufler V, Micoulet A, Kessler H, Boyen HG, Cavalcanti-Adam EA, Spatz JP. Segregation versus colocalization: orthogonally functionalized binary micropatterned substrates regulate the molecular distribution in focal adhesions. Adv Mater, May 15. doi: 10.1002/adma.201500900

3. Wei Q, Pohl TL, Seckinger A, Spatz JP, Cavalcanti-Adam EA. Regulation of integrin and growth factor signaling in biomaterials for osteodifferentiation. Review article. Beilstein J Org Chem 11, 773-783

4. Hauff K, Zambarda C, Dietrich M, Halbig M, Grab AL, Medda R, Cavalcanti-Adam EA. Matrix-immobilized BMP-2 on microcontact printed fibronectin as in vitro tool to study BMP-mediated signaling and cell migration. Themed issue Mimicking concentration gradients in vitro to study cell response in Front Bioeng Biotechnol, May 11;3:62.doi: 10.3389/fbioe.2015.00062

5. Cavalcanti-Adam EA, Spatz JP. Receptor clustering control and associated force sensing by surface patterning; when force matters. Nanomedicine, editorial article, Mar;10(5):681-4. doi: 10.2217/nnm.14.234

6. Schwab EH, Pohl TLM, Haraszti T, Schwaerzer G, Hiepen C, Spatz JP, Knaus P, Cavalcanti-Adam EA. Nanoscale control of surface immobilized BMP-2: toward a quantitative assessment of BMP-mediated signaling events. Nano Lett, doi 10.1021/acs.nanolett.5b00315, Feb 10


7. Berquand A, Medda R, Hauff K, Cavalcanti-Adam EA. Surface immobilized BMP-2 induces increase of C2C12 myoblast cell size and stiffness. Journal of BioNanoscience, in press December, 2014

8. Liu Y, Medda R, Liu Z, Galior K, Yehl K, Spatz JP, Cavalcanti-Adam EA, Salaita K. Nanoparticle tension probes patterned at the nanoscale: impact of integrin clustering on force transmission. Nano Lett, 14(10): 5539-46

9. Medda R, Helth A, Herre P, Pohl D, Rellinghaus B, Perschmann N, Neubauer S, Kessler H, Oswald S, Eckert J, Spatz JP, Gebert A, Cavalcanti-Adam EA. Investigation of early cell-surface interactions of human mesenchymal stem cells on nanopatterned β-type titanium-niobium alloy surfaces. Interface Focus, 4(1): 20130046. doi: 10.1098/rsfs.2013.0046

10. Platzman I, Gadomska KM, Janiesch JW, Louban I, Cavalcanti-Adam EA, Spatz JP. Soft/elastic nanopatterned biointerfaces in the service of cell biology. Methods Cell Biol, 119: 237-60

11. Glenske K, Wagner AS, Hanke T, Cavalcanti-Adam EA, Heinemann S, Heinemann C, Kruppke B, Arnhold S, Moritz A, Schwab EH, Worch H, Wenisch S. Bioactivity of xerogels as modulators of osteoclastogenesis mediated by connexin 43. Biomaterials, 35(5): 1487-95

12. Corall S, Haraszti T, Bartoschick T, Spatz JP, Ludwig T, Cavalcanti-Adam EA. α5β1-integrin and MT1-MMP promote tumor cell migration in 2D but not in 3D fibronectin microenvironments. Comp Mech, 53 (3): 499-510


13. Pohl TL, Schwab EH, Cavalcanti-Adam EA. Covalent binding of BMP-2 on surfaces using a self-assembled monolayer approach. J Vis Exp, 78 doi:10.3791/50842

14. Rahmouni S, Lindner A, Rechenmacher F, Neubauer S, Sobahi TR, Kessler H, Cavalcanti-Adam EA, Spatz JP. Hydrogel micropillars with integrin selective peptidomimetic functionalized nanopatterned tops: a new tool for the measurement of cell traction forces transmitted through αvβ3- or α5β1-integrins. Adv Mater, 25(41): 5869-74

<p><em>14.: We designed the cover page for this journal.</em></p>

14.: We designed the cover page for this journal.

15. Gentile F, Medda R, Cheng L, Battista E, Scopelliti PE, Milani P, Cavalcanti-Adam EA, Decuzzi P. Selective modulation of cell response on engineered fractal silicon substrates. Sci Rep, 3:1461. doi:10.1038/srep01461.

16. Rechenmacher F, Neubauer S, Polleux J, Mas-Moruno C, De Simone M, Cavalcanti-Adam EA, Spatz JP, Fässler R, Kessler H. Functionalizing αvβ3- or α5β1-selective integrin antagonists for surface coating: a method to discriminate integrin subtypes in vitro. Angew Chem Int Ed Engl, 52(5):1572-5

17. Christophis C, Cavalcanti-Adam EA, Hanke M, Kitamura K, Gruverman A, Grunze M, Dowben PA, Rosenhahn A. Adherent cells avoid polarization gradients on periodically poled LiTaO3 ferroelectrics. Biointerphases, 8(1): 8-27

18. Schwab EH, Halbig M, Glenske K, Wagner AS, Wenisch S, Cavalcanti-Adam EA. Distinct effects of RGD-glycoproteins on Integrin-mediated adhesion and osteogenic differentiation of human mesenchymal stem cells. Int J Med Sci, 10(13): 1846-59


19. Cavalcanti-Adam EA, Missirlis D. Nanoscale control of cell behavior on biointerfaces. Book chapter in: Biomimetic approaches for biomaterials development (ed. J. Mano), WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

20. Wenisch S, Cavalcanti-Adam EA, Tryankowski E, Raabe O, Kilian O, Heiss C, Alt V, Arnhold S, Schnettler R. Light- and transmission-electron-microscopic investigations on distribution of CD44, connexin 43 and actin cytoskeleton during the foreign body reaction to a nanoparticular hydroxyapatite in mini-pigs. Acta Biomater, 8(7): 2807-14

21. Pohl TL, Boergermann JH, Schwaerzer GK, Knaus P, Cavalcanti-Adam EA. Surface immobilization of bone morphogenetic protein 2 via a self-assembled monolayer formation induces cell differentiation. Acta Biomater, 8(2): 772-80


22. Aydin D, Louban I, Perschmann N, Blümmel J, Lohmüller T, Cavalcanti-Adam EA, Haas TL, Walczak H, Kessler H, Fiammengo R, Spatz JP. Polymeric substrates with tunable elasticity and nanoscopically controlled biomolecule presentation. Langmuir, 26(19): 15472-80

23. de Beer AG, Cavalcanti-Adam EA, Majer G, Lopez-García M, Kessler H, Spatz JP. Force-induced destabilization of focal adhesions at defined integrin spacings on nanostructured surfaces. Phys Rev E, 81(5): 051914-21


24. Arnold M, Schwieder M, Blümmel J, Cavalcanti-Adam EA, López-Garcia M, Kessler H, Geiger B, Spatz JP. Cell interactions with hierarchically structured nano-patterned adhesive surfaces. Soft Matter, 5(1): 72-77


25. Hirschfeld-Warneken VC, Arnold M, Cavalcanti-Adam A, López-García M, Kessler H, Spatz JP. Cell adhesion and polarization on molecularly defined spacing gradient surfaces of cyclic RGDfK peptide patches. Eur J Cell Biol, 87(8-9): 743-50

26. Arnold M, Hirschfeld-Warneken VC, Lohmüller T, Heil P, Blümmel J, Cavalcanti-Adam EA, López-García M, Walther P, Kessler H, Geiger B, Spatz JP. Induction of cell polarization and migration by a gradient of nanoscale variations in adhesive ligand spacing. Nano Lett, 8(7): 2063-69

27. Cavalcanti-Adam EA, Aydin D, Hirschfeld-Warneken VC, Spatz JP. Cell adhesion and response to synthetic nanopatterned environments by steering receptor clustering and spatial location. HFSP Journal, 2(5): 276-85


28. Secchi AG, Grigoriou V, Shapiro IM, Cavalcanti-Adam EA, Composto RJ, Ducheyne P, Adams CS. RGDS peptides immobilized on titanium alloy stimulate bone cell attachment, differentiation and confer resistance to apoptosis. J Biomed Mater Res A, 83(3): 577-84

29. Cavalcanti-Adam EA, Volberg T, Micoulet A, Kessler H, Geiger B, Spatz JP. Cell spreading and focal adhesion dynamics are regulated by spacing of integrin ligands. Biophys J, 92(8): 2964-74

<p><em>29.: We designed the cover page for this journal.</em></p>

29.: We designed the cover page for this journal.

30. Girard P, Cavalcanti-Adam EA, Kemkemer R, Spatz JP. Cellular chemomechanics at interfaces: sensing, integration and response. Soft Matter, 1: 307-26


31. Cavalcanti-Adam EA, Micoulet A, Blümmel J, Auernheimer J, Kessler H, Spatz JP. Lateral spacing of integrin ligands influences cell spreading and focal adhesion assembly. Eur J Cell Biol, 85(3-4): 219-24, 2006

32. Cavalcanti-Adam EA, Tomakidi P, Bezler M, Spatz JP. The geometric organization of the extracellular matrix in the control of integrin-mediated adhesion and cell function in osteoblasts of the alveolar bone. Progress Orthod, 6(2): 232-37, 2005

33. Grigoriou V, Shapiro IM, Cavalcanti-Adam EA, Composto RJ, Ducheyne P, Adams CS. Apoptosis and survival of osteoblast-like cells are regulated by surface attachment. J Biol Chem, 280(3): 1733-39, 2005

34. Glass R, Arnold M, Cavalcanti-Adam EA, Bluemmel J, Haferkemper C, Dodd C, Spatz JP. Block copolymer micelle nanolithography on non-conductive substrates. New J Phys, 6 (101): 1-17, 2004

35. Arnold M, Cavalcanti-Adam EA, Glass R, Blümmel J, Eck W, Kantlehner M, Kessler H, Spatz JP. Activation of integrin function by nanopatterned adhesive interfaces. Chemphyschem, 5(3): 383-88, 2004

<p><em>35.: We designed the cover page for this journal.</em></p>

35.: We designed the cover page for this journal.

36. Cavalcanti-Adam EA, Shapiro IM, Composto RJ, Macarak EJ, Adams CS. Dynamic Equibiaxial Strain Causes Intracellular Changes in Osteoblasts Cultured on RGD-engineered Surfaces. J Bone Miner Research, 17(12): 2130-41, 2002

37. Chung CH, Vanarsdall RL, Cavalcanti EA, Baldinger JS, Lai CH. Comparison of microbial composition in the subgingival plaque of adult crowded versus non-crowded dental regions. Intl J. Adult Orthod and Orthognat Surg, 15(4): 321-30, 2000

38. Castaldo A, Spada E, Cavalcanti EA. Rapporto fra le caratteristiche dimensionali e morfologiche dei seni frontali e malocclusioni (Relationship between dimensional and morphological characteristics of frontal sinuses and malocclusions). Ortognatodonzia Italiana, 6(5): 655-66, 1997

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