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2020


Walking Control Based on Step Timing Adaptation
Walking Control Based on Step Timing Adaptation

Khadiv, M., Herzog, A., Moosavian, S. A. A., Righetti, L.

IEEE Transactions on Robotics, 36, pages: 629 - 643, IEEE, June 2020 (article)

Abstract
Step adjustment can improve the gait robustness of biped robots; however, the adaptation of step timing is often neglected as it gives rise to nonconvex problems when optimized over several footsteps. In this article, we argue that it is not necessary to optimize walking over several steps to ensure gait viability and show that it is sufficient to merely select the next step timing and location. Using this insight, we propose a novel walking pattern generator that optimally selects step location and timing at every control cycle. Our approach is computationally simple compared to standard approaches in the literature, yet guarantees that any viable state will remain viable in the future. We propose a swing foot adaptation strategy and integrate the pattern generator with an inverse dynamics controller that does not explicitly control the center of mass nor the foot center of pressure. This is particularly useful for biped robots with limited control authority over their foot center of pressure, such as robots with point feet or passive ankles. Extensive simulations on a humanoid robot with passive ankles demonstrate the capabilities of the approach in various walking situations, including external pushes and foot slippage, and emphasize the importance of step timing adaptation to stabilize walking.

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link (url) DOI [BibTex]

2020


link (url) DOI [BibTex]


Statistical reprogramming of macroscopic self-assembly with dynamic boundaries
Statistical reprogramming of macroscopic self-assembly with dynamic boundaries

Culha, U., Davidson, Z. S., Mastrangeli, M., Sitti, M.

Proceedings of the National Academy of Sciences, 117(21):11306-11313, May 2020 (article)

Abstract
Self-assembly is a ubiquitous process that can generate complex and functional structures via local interactions among a large set of simpler components. The ability to program the self-assembly pathway of component sets elucidates fundamental physics and enables alternative competitive fabrication technologies. Reprogrammability offers further opportunities for tuning structural and material properties but requires reversible selection from multistable self-assembling patterns, which remains a challenge. Here, we show statistical reprogramming of two-dimensional (2D), noncompact self-assembled structures by the dynamic confinement of orbitally shaken and magnetically repulsive millimeter-scale particles. Under a constant shaking regime, we control the rate of radius change of an assembly arena via moving hard boundaries and select among a finite set of self-assembled patterns repeatably and reversibly. By temporarily trapping particles in topologically identified stable states, we also demonstrate 2D reprogrammable stiffness and three-dimensional (3D) magnetic clutching of the self-assembled structures. Our reprogrammable system has prospective implications for the design of granular materials in a multitude of physical scales where out-of-equilibrium self-assembly can be realized with different numbers or types of particles. Our dynamic boundary regulation may also enable robust bottom-up control strategies for novel robotic assembly applications by designing more complex spatiotemporal interactions using mobile robots.

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DOI [BibTex]

DOI [BibTex]


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Adaptation and Robust Learning of Probabilistic Movement Primitives

Gomez-Gonzalez, S., Neumann, G., Schölkopf, B., Peters, J.

IEEE Transactions on Robotics, 36(2):366-379, IEEE, March 2020 (article)

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arXiv DOI Project Page [BibTex]

arXiv DOI Project Page [BibTex]


Gripping apparatus and method of producing a gripping apparatus
Gripping apparatus and method of producing a gripping apparatus

Song, S., Sitti, M., Drotlef, D., Majidi, C.

Google Patents, Febuary 2020, US Patent App. 16/610,209 (patent)

Abstract
The present invention relates to a gripping apparatus comprising a membrane; a flexible housing; with said membrane being fixedly connected to a periphery of the housing. The invention further relates to a method of producing a gripping apparatus.

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[BibTex]

[BibTex]


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Real Time Trajectory Prediction Using Deep Conditional Generative Models

Gomez-Gonzalez, S., Prokudin, S., Schölkopf, B., Peters, J.

IEEE Robotics and Automation Letters, 5(2):970-976, IEEE, January 2020 (article)

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arXiv DOI [BibTex]

arXiv DOI [BibTex]


Method of actuating a shape changeable member, shape changeable member and actuating system
Method of actuating a shape changeable member, shape changeable member and actuating system

Hu, W., Lum, G. Z., Mastrangeli, M., Sitti, M.

Google Patents, January 2020, US Patent App. 16/477,593 (patent)

Abstract
The present invention relates to a method of actuating a shape changeable member of actuatable material. The invention further relates to a shape changeable member and to a system comprising such a shape changeable member and a magnetic field apparatus.

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[BibTex]


Thermal Effects on the Crystallization Kinetics, and Interfacial Adhesion of Single-Crystal Phase-Change Gallium
Thermal Effects on the Crystallization Kinetics, and Interfacial Adhesion of Single-Crystal Phase-Change Gallium

Yunusa, M., Lahlou, A., Sitti, M.

Advanced Materials, Wiley Online Library, 2020 (article)

Abstract
Although substrates play an important role upon crystallization of supercooled liquids, the influences of surface temperature and thermal property have remained elusive. Here, the crystallization of supercooled phase‐change gallium (Ga) on substrates with different thermal conductivity is studied. The effect of interfacial temperature on the crystallization kinetics, which dictates thermo‐mechanical stresses between the substrate and the crystallized Ga, is investigated. At an elevated surface temperature, close to the melting point of Ga, an extended single‐crystal growth of Ga on dielectric substrates due to layering effect and annealing is realized without the application of external fields. Adhesive strength at the interfaces depends on the thermal conductivity and initial surface temperature of the substrates. This insight can be applicable to other liquid metals for industrial applications, and sheds more light on phase‐change memory crystallization.

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[BibTex]


Nanoerythrosome-functionalized biohybrid microswimmers
Nanoerythrosome-functionalized biohybrid microswimmers

Buss, N., Yasa, O., Alapan, Y., Akolpoglu, M. B., Sitti, M.

APL Bioengineering, 4, AIP Publishing LLC, 2020 (article)

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[BibTex]

[BibTex]


Injectable Nanoelectrodes Enable Wireless Deep Brain Stimulation of Native Tissue in Freely Moving Mice
Injectable Nanoelectrodes Enable Wireless Deep Brain Stimulation of Native Tissue in Freely Moving Mice

Kozielski, K. L., Jahanshahi, A., Gilbert, H. B., Yu, Y., Erin, O., Francisco, D., Alosaimi, F., Temel, Y., Sitti, M.

bioRxiv, Cold Spring Harbor Laboratory, 2020 (article)

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[BibTex]

[BibTex]


Magnetically Actuated Soft Capsule Endoscope for Fine-Needle Biopsy
Magnetically Actuated Soft Capsule Endoscope for Fine-Needle Biopsy

Son, D., Gilbert, H., Sitti, M.

Soft robotics, Mary Ann Liebert, Inc., publishers 140 Huguenot Street, 3rd Floor New …, 2020 (article)

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[BibTex]

[BibTex]


Mechanical coupling of puller and pusher active microswimmers influences motility
Mechanical coupling of puller and pusher active microswimmers influences motility

Singh, A. V., Kishore, V., Santamauro, G., Yasa, O., Bill, J., Sitti, M.

Langmuir, ACS Publications, 2020 (article)

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[BibTex]


Microribbons composed of directionally self-assembled nanoflakes as highly stretchable ionic neural electrodes
Microribbons composed of directionally self-assembled nanoflakes as highly stretchable ionic neural electrodes

Zhang, M., Guo, R., Chen, K., Wang, Y., Niu, J., Guo, Y., Zhang, Y., Yin, Z., Xia, K., Zhou, B., Wang, H., He, W., Liu, J., Sitti, M., Zhang, Y.

Proceedings of the National Academy of Sciences, National Academy of Sciences, 2020 (article)

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link (url) DOI [BibTex]

link (url) DOI [BibTex]


Controlling two-dimensional collective formation and cooperative behavior of magnetic microrobot swarms
Controlling two-dimensional collective formation and cooperative behavior of magnetic microrobot swarms

Dong, X., Sitti, M.

The International Journal of Robotics Research, 2020 (article)

Abstract
Magnetically actuated mobile microrobots can access distant, enclosed, and small spaces, such as inside microfluidic channels and the human body, making them appealing for minimally invasive tasks. Despite their simplicity when scaling down, creating collective microrobots that can work closely and cooperatively, as well as reconfigure their formations for different tasks, would significantly enhance their capabilities such as manipulation of objects. However, a challenge of realizing such cooperative magnetic microrobots is to program and reconfigure their formations and collective motions with under-actuated control signals. This article presents a method of controlling 2D static and time-varying formations among collective self-repelling ferromagnetic microrobots (100 μm to 350 μm in diameter, up to 260 in number) by spatially and temporally programming an external magnetic potential energy distribution at the air–water interface or on solid surfaces. A general design method is introduced to program external magnetic potential energy using ferromagnets. A predictive model of the collective system is also presented to predict the formation and guide the design procedure. With the proposed method, versatile complex static formations are experimentally demonstrated and the programmability and scaling effects of formations are analyzed. We also demonstrate the collective mobility of these magnetic microrobots by controlling them to exhibit bio-inspired collective behaviors such as aggregation, directional motion with arbitrary swarm headings, and rotational swarming motion. Finally, the functions of the produced microrobotic swarm are demonstrated by controlling them to navigate through cluttered environments and complete reconfigurable cooperative manipulation tasks.

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DOI [BibTex]


Magnetic Resonance Imaging System--Driven Medical Robotics
Magnetic Resonance Imaging System–Driven Medical Robotics

Erin, O., Boyvat, M., Tiryaki, M. E., Phelan, M., Sitti, M.

Advanced Intelligent Systems, 2, Wiley Online Library, 2020 (article)

Abstract
Magnetic resonance imaging (MRI) system–driven medical robotics is an emerging field that aims to use clinical MRI systems not only for medical imaging but also for actuation, localization, and control of medical robots. Submillimeter scale resolution of MR images for soft tissues combined with the electromagnetic gradient coil–based magnetic actuation available inside MR scanners can enable theranostic applications of medical robots for precise image‐guided minimally invasive interventions. MRI‐driven robotics typically does not introduce new MRI instrumentation for actuation but instead focuses on converting already available instrumentation for robotic purposes. To use the advantages of this technology, various medical devices such as untethered mobile magnetic robots and tethered active catheters have been designed to be powered magnetically inside MRI systems. Herein, the state‐of‐the‐art progress, challenges, and future directions of MRI‐driven medical robotic systems are reviewed.

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[BibTex]

[BibTex]


Characterization and Thermal Management of a DC Motor-Driven Resonant Actuator for Miniature Mobile Robots with Oscillating Limbs
Characterization and Thermal Management of a DC Motor-Driven Resonant Actuator for Miniature Mobile Robots with Oscillating Limbs

Colmenares, D., Kania, R., Liu, M., Sitti, M.

arXiv preprint arXiv:2002.00798, 2020 (article)

Abstract
In this paper, we characterize the performance of and develop thermal management solutions for a DC motor-driven resonant actuator developed for flapping wing micro air vehicles. The actuator, a DC micro-gearmotor connected in parallel with a torsional spring, drives reciprocal wing motion. Compared to the gearmotor alone, this design increased torque and power density by 161.1% and 666.8%, respectively, while decreasing the drawn current by 25.8%. Characterization of the actuator, isolated from nonlinear aerodynamic loading, results in standard metrics directly comparable to other actuators. The micro-motor, selected for low weight considerations, operates at high power for limited duration due to thermal effects. To predict system performance, a lumped parameter thermal circuit model was developed. Critical model parameters for this micro-motor, two orders of magnitude smaller than those previously characterized, were identified experimentally. This included the effects of variable winding resistance, bushing friction, speed-dependent forced convection, and the addition of a heatsink. The model was then used to determine a safe operation envelope for the vehicle and to design a weight-optimal heatsink. This actuator design and thermal modeling approach could be applied more generally to improve the performance of any miniature mobile robot or device with motor-driven oscillating limbs or loads.

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[BibTex]


Pros and Cons: Magnetic versus Optical Microrobots
Pros and Cons: Magnetic versus Optical Microrobots

Sitti, M., Wiersma, D. S.

Advanced Materials, Wiley Online Library, 2020 (article)

Abstract
Mobile microrobotics has emerged as a new robotics field within the last decade to create untethered tiny robots that can access and operate in unprecedented, dangerous, or hard‐to‐reach small spaces noninvasively toward disruptive medical, biotechnology, desktop manufacturing, environmental remediation, and other potential applications. Magnetic and optical actuation methods are the most widely used actuation methods in mobile microrobotics currently, in addition to acoustic and biological (cell‐driven) actuation approaches. The pros and cons of these actuation methods are reported here, depending on the given context. They can both enable long‐range, fast, and precise actuation of single or a large number of microrobots in diverse environments. Magnetic actuation has unique potential for medical applications of microrobots inside nontransparent tissues at high penetration depths, while optical actuation is suitable for more biotechnology, lab‐/organ‐on‐a‐chip, and desktop manufacturing types of applications with much less surface penetration depth requirements or with transparent environments. Combining both methods in new robot designs can have a strong potential of combining the pros of both methods. There is still much progress needed in both actuation methods to realize the potential disruptive applications of mobile microrobots in real‐world conditions.

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[BibTex]

[BibTex]


Selectively Controlled Magnetic Microrobots with Opposing Helices
Selectively Controlled Magnetic Microrobots with Opposing Helices

Giltinan, J., Katsamba, P., Wang, W., Lauga, E., Sitti, M.

Applied Physics Letters, 116, AIP Publishing LLC, 2020 (article)

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[BibTex]

[BibTex]


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An Adaptive Optimizer for Measurement-Frugal Variational Algorithms

Kübler, J. M., Arrasmith, A., Cincio, L., Coles, P. J.

Quantum, 4, pages: 263, 2020 (article)

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link (url) DOI [BibTex]

link (url) DOI [BibTex]


Microscale Polarization Color Pixels from Liquid Crystal Elastomers
Microscale Polarization Color Pixels from Liquid Crystal Elastomers

Guo, Y., Shahsavan, H., Sitti, M.

Advanced Optical Materials, Wiley Online Library, 2020 (article)

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[BibTex]

[BibTex]


Wearable and Stretchable Strain Sensors: Materials, Sensing Mechanisms, and Applications
Wearable and Stretchable Strain Sensors: Materials, Sensing Mechanisms, and Applications

Souri, H., Banerjee, H., Jusufi, A., Radacsi, N., Stokes, A. A., Park, I., Sitti, M., Amjadi, M.

Advanced Intelligent Systems, 2020 (article)

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link (url) DOI [BibTex]

link (url) DOI [BibTex]


Ultrasound-guided Wireless Tubular Robotic Anchoring System
Ultrasound-guided Wireless Tubular Robotic Anchoring System

Wang, T., Hu, W., Ren, Z., Sitti, M.

IEEE Robotics and Automation Letters, 5, pages: 4859 - 4866, IEEE, 2020 (article)

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link (url) DOI [BibTex]

link (url) DOI [BibTex]


Cohesive self-organization of mobile microrobotic swarms
Cohesive self-organization of mobile microrobotic swarms

Yigit, B., Alapan, Y., Sitti, M.

arXiv preprint arXiv:1907.05856, 2020 (article)

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[BibTex]

[BibTex]


Bio-inspired Flexible Twisting Wings Increase Lift and Efficiency of a Flapping Wing Micro Air Vehicle
Bio-inspired Flexible Twisting Wings Increase Lift and Efficiency of a Flapping Wing Micro Air Vehicle

Colmenares, D., Kania, R., Zhang, W., Sitti, M.

arXiv preprint arXiv:2001.11586, 2020 (article)

Abstract
We investigate the effect of wing twist flexibility on lift and efficiency of a flapping-wing micro air vehicle capable of liftoff. Wings used previously were chosen to be fully rigid due to modeling and fabrication constraints. However, biological wings are highly flexible and other micro air vehicles have successfully utilized flexible wing structures for specialized tasks. The goal of our study is to determine if dynamic twisting of flexible wings can increase overall aerodynamic lift and efficiency. A flexible twisting wing design was found to increase aerodynamic efficiency by 41.3%, translational lift production by 35.3%, and the effective lift coefficient by 63.7% compared to the rigid-wing design. These results exceed the predictions of quasi-steady blade element models, indicating the need for unsteady computational fluid dynamics simulations of twisted flapping wings.

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[BibTex]

[BibTex]


Acoustically powered surface-slipping mobile microrobots
Acoustically powered surface-slipping mobile microrobots

Aghakhani, A., Yasa, O., Wrede, P., Sitti, M.

Proceedings of the National Academy of Sciences, 117, National Acad Sciences, 2020 (article)

Abstract
Untethered synthetic microrobots have significant potential to revolutionize minimally invasive medical interventions in the future. However, their relatively slow speed and low controllability near surfaces typically are some of the barriers standing in the way of their medical applications. Here, we introduce acoustically powered microrobots with a fast, unidirectional surface-slipping locomotion on both flat and curved surfaces. The proposed three-dimensionally printed, bullet-shaped microrobot contains a spherical air bubble trapped inside its internal body cavity, where the bubble is resonated using acoustic waves. The net fluidic flow due to the bubble oscillation orients the microrobot's axisymmetric axis perpendicular to the wall and then propels it laterally at very high speeds (up to 90 body lengths per second with a body length of 25 µm) while inducing an attractive force toward the wall. To achieve unidirectional locomotion, a small fin is added to the microrobot’s cylindrical body surface, which biases the propulsion direction. For motion direction control, the microrobots are coated anisotropically with a soft magnetic nanofilm layer, allowing steering under a uniform magnetic field. Finally, surface locomotion capability of the microrobots is demonstrated inside a three-dimensional circular cross-sectional microchannel under acoustic actuation. Overall, the combination of acoustic powering and magnetic steering can be effectively utilized to actuate and navigate these microrobots in confined and hard-to-reach body location areas in a minimally invasive fashion.

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[BibTex]

[BibTex]


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Morphology-Dependent Immunogenicity Obliges a Compromise on the Locomotion-Focused Design of Medical Microrobots

Ceren, , Hakan, , Ugur, , Anna-Maria, , Metin,

Science Robotics, 2020 (article) Accepted

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[BibTex]

[BibTex]


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Counterfactual Mean Embedding

Muandet, K., Kanagawa, M., Saengkyongam, S., Marukatat, S.

Journal of Machine Learning Research, 2020 (article) Accepted

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[BibTex]

[BibTex]


Selection for Function: From Chemically Synthesized Prototypes to 3D-Printed Microdevices
Selection for Function: From Chemically Synthesized Prototypes to 3D-Printed Microdevices

Bachmann, F., Giltinan, J., Codutti, A., Klumpp, S., Sitti, M., Faivre, D.

Advanced Intelligent Systems, 2020 (article)

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[BibTex]

[BibTex]


Bioinspired underwater locomotion of light-driven liquid crystal gels
Bioinspired underwater locomotion of light-driven liquid crystal gels

Shahsavan, H., Aghakhani, A., Zeng, H., Guo, Y., Davidson, Z. S., Priimagi, A., Sitti, M.

Proceedings of the National Academy of Sciences, National Acad Sciences, 2020 (article)

Abstract
Untethered dynamic shape programming and control of soft materials have significant applications in technologies such as soft robots, medical devices, organ-on-a-chip, and optical devices. Here, we present a solution to remotely actuate and move soft materials underwater in a fast, efficient, and controlled manner using photoresponsive liquid crystal gels (LCGs). LCG constructs with engineered molecular alignment show a low and sharp phase-transition temperature and experience considerable density reduction by light exposure, thereby allowing rapid and reversible shape changes. We demonstrate different modes of underwater locomotion, such as crawling, walking, jumping, and swimming, by localized and time-varying illumination of LCGs. The diverse locomotion modes of smart LCGs can provide a new toolbox for designing efficient light-fueled soft robots in fluid-immersed media.

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[BibTex]

[BibTex]


Additive manufacturing of cellulose-based materials with continuous, multidirectional stiffness gradients
Additive manufacturing of cellulose-based materials with continuous, multidirectional stiffness gradients

Giachini, P., Gupta, S., Wang, W., Wood, D., Yunusa, M., Baharlou, E., Sitti, M., Menges, A.

Science Advances, 6, American Association for the Advancement of Science, 2020 (article)

Abstract
Functionally graded materials (FGMs) enable applications in fields such as biomedicine and architecture, but their fabrication suffers from shortcomings in gradient continuity, interfacial bonding, and directional freedom. In addition, most commercial design software fail to incorporate property gradient data, hindering explorations of the design space of FGMs. Here, we leveraged a combined approach of materials engineering and digital processing to enable extrusion-based multimaterial additive manufacturing of cellulose-based tunable viscoelastic materials with continuous, high-contrast, and multidirectional stiffness gradients. A method to engineer sets of cellulose-based materials with similar compositions, yet distinct mechanical and rheological properties, was established. In parallel, a digital workflow was developed to embed gradient information into design models with integrated fabrication path planning. The payoff of integrating these physical and digital tools is the ability to achieve the same stiffness gradient in multiple ways, opening design possibilities previously limited by the rigid coupling of material and geometry.

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[BibTex]

[BibTex]


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Introducing Progress in Biomedical Engineering; Issue 2 Vol 2

Sitti, M.

Progress in Biomedical Engineering, IOP Publishing, 2020 (article)

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[BibTex]

[BibTex]


Multi-wavelength steerable visible light-driven magnetic CoO-TiO2 microswimmers
Multi-wavelength steerable visible light-driven magnetic CoO-TiO2 microswimmers

Sridhar, V., Park, B., Guo, S., van Aken, P. A., Sitti, M.

ACS Applied Materials \& Interfaces, ACS Publications, 2020 (article)

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[BibTex]

[BibTex]

2014


Series of Multilinked Caterpillar Track-type Climbing Robots
Series of Multilinked Caterpillar Track-type Climbing Robots

Lee, G., Kim, H., Seo, K., Kim, J., Sitti, M., Seo, T.

Journal of Field Robotics, November 2014 (article)

Abstract
Climbing robots have been widely applied in many industries involving hard to access, dangerous, or hazardous environments to replace human workers. Climbing speed, payload capacity, the ability to overcome obstacles, and wall-to-wall transitioning are significant characteristics of climbing robots. Here, multilinked track wheel-type climbing robots are proposed to enhance these characteristics. The robots have been developed for five years in collaboration with three universities: Seoul National University, Carnegie Mellon University, and Yeungnam University. Four types of robots are presented for different applications with different surface attachment methods and mechanisms: MultiTank for indoor sites, Flexible caterpillar robot (FCR) and Combot for heavy industrial sites, and MultiTrack for high-rise buildings. The method of surface attachment is different for each robot and application, and the characteristics of the joints between links are designed as active or passive according to the requirement of a given robot. Conceptual design, practical design, and control issues of such climbing robot types are reported, and a proper choice of the attachment methods and joint type is essential for the successful multilink track wheel-type climbing robot for different surface materials, robot size, and computational costs.

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DOI [BibTex]

2014


DOI [BibTex]


Segmented molecular design of self-healing proteinaceous materials.
Segmented molecular design of self-healing proteinaceous materials.

Sariola, V., Pena-Francesch, A., Jung, H., Çetinkaya, M., Pacheco, C., Sitti, M., Demirel, M. C.

Scientific reports, 5, pages: 13482-13482, Nature Publishing Group, July 2014 (article)

Abstract
Hierarchical assembly of self-healing adhesive proteins creates strong and robust structural and interfacial materials, but understanding of the molecular design and structure–property relationships of structural proteins remains unclear. Elucidating this relationship would allow rational design of next generation genetically engineered self-healing structural proteins. Here we report a general self-healing and -assembly strategy based on a multiphase recombinant protein based material. Segmented structure of the protein shows soft glycine- and tyrosine-rich segments with self-healing capability and hard beta-sheet segments. The soft segments are strongly plasticized by water, lowering the self-healing temperature close to body temperature. The hard segments self-assemble into nanoconfined domains to reinforce the material. The healing strength scales sublinearly with contact time, which associates with diffusion and wetting of autohesion. The finding suggests that recombinant structural proteins from heterologous expression have potential as strong and repairable engineering materials.

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DOI [BibTex]

DOI [BibTex]


Bio-Hybrid Cell-Based Actuators for Microsystems
Bio-Hybrid Cell-Based Actuators for Microsystems

Carlsen, R. W., Sitti, M.

Small, 10(19):3831-3851, June 2014 (article)

Abstract
As we move towards the miniaturization of devices to perform tasks at the nano and microscale, it has become increasingly important to develop new methods for actuation, sensing, and control. Over the past decade, bio-hybrid methods have been investigated as a promising new approach to overcome the challenges of scaling down robotic and other functional devices. These methods integrate biological cells with artificial components and therefore, can take advantage of the intrinsic actuation and sensing functionalities of biological cells. Here, the recent advancements in bio-hybrid actuation are reviewed, and the challenges associated with the design, fabrication, and control of bio-hybrid microsystems are discussed. As a case study, focus is put on the development of bacteria-driven microswimmers, which has been investigated as a targeted drug delivery carrier. Finally, a future outlook for the development of these systems is provided. The continued integration of biological and artificial components is envisioned to enable the performance of tasks at a smaller and smaller scale in the future, leading to the parallel and distributed operation of functional systems at the microscale.

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DOI [BibTex]

DOI [BibTex]


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Method and device for blind correction of optical aberrations in a digital image

Schuler, C., Hirsch, M., Harmeling, S., Schölkopf, B.

International Patent Application, No. PCT/EP2012/068868, April 2014 (patent)

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[BibTex]


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Juggling revisited — A voxel based morphometry study with expert jugglers

Gerber, P., Schlaffke, L., Heba, S., Greenlee, M., Schultz, T., Schmidt-Wilcke, T.

NeuroImage, 95, pages: 320-325, 2014 (article)

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Web DOI [BibTex]

Web DOI [BibTex]


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Assessing attention and cognitive function in completely locked-in state with event-related brain potentials and epidural electrocorticography

Bensch, M., Martens, S., Halder, S., Hill, J., Nijboer, F., Ramos, A., Birbaumer, N., Bodgan, M., Kotchoubey, B., Rosenstiel, W., Schölkopf, B., Gharabaghi, A.

Journal of Neural Engineering, 11(2):026006, 2014 (article)

Abstract
Objective. Patients in the completely locked-in state (CLIS), due to, for example, amyotrophic lateral sclerosis (ALS), no longer possess voluntary muscle control. Assessing attention and cognitive function in these patients during the course of the disease is a challenging but essential task for both nursing staff and physicians. Approach. An electrophysiological cognition test battery, including auditory and semantic stimuli, was applied in a late-stage ALS patient at four different time points during a six-month epidural electrocorticography (ECoG) recording period. Event-related cortical potentials (ERP), together with changes in the ECoG signal spectrum, were recorded via 128 channels that partially covered the left frontal, temporal and parietal cortex. Main results. Auditory but not semantic stimuli induced significant and reproducible ERP projecting to specific temporal and parietal cortical areas. N1/P2 responses could be detected throughout the whole study period. The highest P3 ERP was measured immediately after the patient's last communication through voluntary muscle control, which was paralleled by low theta and high gamma spectral power. Three months after the patient's last communication, i.e., in the CLIS, P3 responses could no longer be detected. At the same time, increased activity in low-frequency bands and a sharp drop of gamma spectral power were recorded. Significance. Cortical electrophysiological measures indicate at least partially intact attention and cognitive function during sparse volitional motor control for communication. Although the P3 ERP and frequency-specific changes in the ECoG spectrum may serve as indicators for CLIS, a close-meshed monitoring will be required to define the exact time point of the transition.

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DOI [BibTex]

DOI [BibTex]


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Identifiability of Gaussian Structural Equation Models with Equal Error Variances

Peters, J., Bühlman, P.

Biometrika, 101(1):219-228, 2014 (article)

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DOI [BibTex]


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Quantifying the effect of intertrial dependence on perceptual decisions

Fründ, I., Wichmann, F., Macke, J.

Journal of Vision, 14(7):1-16, 2014 (article)

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Web PDF link (url) DOI [BibTex]

Web PDF link (url) DOI [BibTex]


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Two numerical models designed to reproduce Saturn ring temperatures as measured by Cassini-CIRS

Altobelli, N., Lopez-Paz, D., Pilorz, S., Spilker, L., Morishima, R., Brooks, S., Leyrat, C., Deau, E., Edgington, S., Flandes, A.

Icarus, 238(0):205 - 220, 2014 (article)

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Web link (url) DOI [BibTex]

Web link (url) DOI [BibTex]


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Policy Evaluation with Temporal Differences: A Survey and Comparison

Dann, C., Neumann, G., Peters, J.

Journal of Machine Learning Research, 15, pages: 809-883, 2014 (article)

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PDF [BibTex]

PDF [BibTex]